[BIC-announce] Fwd: Neuro Event: Feindel Seminar Series -Linking microscopy-derived microstructure to MRI signals throughout the macaque brain - November 16, 4 p.m.

Wed Nov 16 14:11:28 EST 2022

Hi BIC, happening at 4 today @DGP.
Cheers,
Boris
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Date: Nov 14, 2022, 1:48 AM -0500
To: NeuroEvents <events.neuro at mcgill.ca>

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[Text Description automatically generated with low confidence]

Linking microscopy-derived microstructure to MRI signals throughout the macaque brain

Amy Howard

Postdoctoral researcher, Diffusion MRI, University of Oxford, UK

Wednesday, November 16, 2022

4 p.m. EST

The Neuro, 3801 rue University, De Grandpré Communications Centre

You must register here to attend in person<https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.eventbrite.ca%2Fe%2Ffeindel-brain-and-mind-seminar-amy-howard-tickets-453053734917&data=05%7C01%7Cboris.bernhardt%40mcgill.ca%7Cb6a0b145b998493c388408dac670df9a%7Ccd31967152e74a68afa9fcf8f89f09ea%7C0%7C0%7C638040485353858566%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=3zv3yZwPwiAixN%2FPRl6YnZvVDwQLt7h9jmSU0Cy6tx8%3D&reserved=0>

Abstract: Understanding brain structure and function often requires combining data across different modalities and scales to link microscale cellular structures to macroscale features of whole brain organisation. Here we introduce the BigMac dataset, a resource combining in vivo MRI, extensive postmortem MRI and multi-contrast microscopy for multimodal characterisation of a single whole macaque brain. The data spans modalities (MRI and microscopy), tissue states (in vivo and postmortem), and four orders of spatial magnitude, from microscopy images with micrometre or sub-micrometre resolution, to MRI signals on the order of millimetres. Crucially, the MRI and microscopy images are carefully co-registered together to facilitate quantitative multimodal analyses. In this talk I will detail the acquisition, curation, and first release of the data, that together make BigMac a unique, openly-disseminated resource available to researchers worldwide. Further, I will demonstrate example analyses and opportunities afforded by the data, including improvement of connectivity estimates from ultra-high angular resolution diffusion MRI, neuroanatomical insight provided by polarised light imaging and myelin-stained histology, and the joint analysis of MRI and microscopy data for reconstruction of the microscopy-inspired connectome.

The Feindel Seminar Series at The Neuro

Advances the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.

Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.

Contact: Sasha Kelly<mailto:sasha.kelly at mcgill.ca>, Conference and Events Coordinator, The Neuro

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