[Ace-analysis] Air pollution abstract - comments by 11/29

Tue Nov 29 10:36:07 EST 2022

Hi Irena,

This is excellent work; I agree with others that it’s so exciting the air pollution study has reached this milestone!

I made some suggested edits on your updated version V3, and I trimmed ~30 words from the abstract so you may have room to address other people’s feedback. I also suggested edits to the title and conclusions/significance.

One thing missing was the *timing* of the exposure. The timing is an incredibly innovative aspect of this study: the air pollution exposure occurred before the brain growth changes and well before ASD diagnosis.

Many thanks to you and Heather V. for leading this exciting research,
Mark

_______________________________________
Mark D. Shen, Ph.D. (he/him/his)
Asst. Professor
Co-Director, CIDD Clinical Trials Program
Carolina Institute for Developmental Disabilities
Neuroscience Center & Dept. of Psychiatry
UNC School of Medicine
https://markshenlab.org/
_______________________________________

On Nov 28, 2022, at 5:26 PM, Tanya St. John <tstjohn at uw.edu<mailto:tstjohn at uw.edu>> wrote:

Nice work Irena! It is nice to see this data pulled together.

With regards to the revised abstract you sent, I only had one minor suggestion. I didn't see a statement about how many children with ASD there are in your sample or how many with ASD ended up in each class. You stated that most were in the low volume class but is not clear whether the percentages refer just to children with ASD or to all children in the sample. My guess is all given the n's but since your focus is on autism, I would make the explicit.

Thanks for including me!

Tanya

Tanya St. John, Ph.D.  (she/her)
Licensed Clinical Psychologist
Research Scientist
Department of Speech and Hearing Sciences
University of Washington Autism Center
CHDD Box 357920
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From: ace-analysis-bounces at bic.mni.mcgill.ca<mailto:ace-analysis-bounces at bic.mni.mcgill.ca> <ace-analysis-bounces at bic.mni.mcgill.ca<mailto:ace-analysis-bounces at bic.mni.mcgill.ca>> on behalf of Piven, Joseph <jpiven at med.unc.edu<mailto:jpiven at med.unc.edu>>
Sent: Monday, November 28, 2022 2:02 PM
To: Girault, Jessica B. <jessica_girault at med.unc.edu<mailto:jessica_girault at med.unc.edu>>; ace-project at bic.mni.mcgill.ca<mailto:ace-project at bic.mni.mcgill.ca> <ace-project at bic.mni.mcgill.ca<mailto:ace-project at bic.mni.mcgill.ca>>; ace-analysis at bic.mni.mcgill.ca<mailto:ace-analysis at bic.mni.mcgill.ca> <ace-analysis at bic.mni.mcgill.ca<mailto:ace-analysis at bic.mni.mcgill.ca>>
Cc: Irena Steiner <igorski1 at jhu.edu<mailto:igorski1 at jhu.edu>>
Subject: Re: [Ace-analysis] Air pollution abstract - comments by 11/29

So good to see this work moving forward.
A few thoughts:

  1.  In the title, ‘Autism Spectrum Disorder in Infants’ may be a bit misleading and also forfeits your opportunity to make the point it is prior to consolidation of diagnosis.  If you need space, you might cut ‘Total Tissue’ and use ‘Brain Volume Trajectories’.
  2.  Same comment in the Background – growth rates during infancy in those with and without ASD is a bit misleading.  ‘at risk’ for ASD seems to go hand in hand with a study of risk from AP exposure, as far as timing.  Has the association between AP and brain volume been with increased or decreased volume.  I thought it was the latter.
  3.  Results:  maybe change ‘we discovered’ to ‘we observed’.  ‘Higher residential …  ‘H’ should not be caps.
  4.  Conclusion:  I don’t think the results contrast with previous observations of rain enlargement in ASD.  We always knew it was only in a subset. And that ASD is heterogeneous.  I would probably take out that line and instead frame it as these results may serve to tease apart phenotypes related to the well known underlying heterogeneous (genetic and environmental) etiologic contributors.

jp

From: ace-analysis-bounces at bic.mni.mcgill.ca<mailto:ace-analysis-bounces at bic.mni.mcgill.ca> <ace-analysis-bounces at bic.mni.mcgill.ca<mailto:ace-analysis-bounces at bic.mni.mcgill.ca>> On Behalf Of Girault, Jessica B.
Sent: Wednesday, November 23, 2022 8:34 AM
To: ace-project at bic.mni.mcgill.ca<mailto:ace-project at bic.mni.mcgill.ca>; ace-analysis at bic.mni.mcgill.ca<mailto:ace-analysis at bic.mni.mcgill.ca>
Cc: Irena Steiner <igorski1 at jhu.edu<mailto:igorski1 at jhu.edu>>
Subject: [Ace-analysis] Air pollution abstract - comments by 11/29

Dear Colleagues,

Heather Volk's team has an abstract for ISEE NAC describing analyses of pollution data in relation to brain volumes.

Please see attached and provide and feedback to Irena, the first author (copied here), by 11/29.

If you would like to be included as an author, please let her know.

Thank you,

Jessica

_____________________________________
Jessica B. Girault, PhD
Assistant Professor
Carolina Institute for Developmental Disabilities
Department of Psychiatry
University of North Carolina at Chapel Hill
https://giraultlab.unc.edu/<https://urldefense.com/v3/__https://giraultlab.unc.edu/__;!!K-Hz7m0Vt54!j7k7SfN_Sylft29NwOu12FhLBjttLRuF6LjO4hBAVIntomDr0RjO_SZUmBPK4CQ4ovbd90J2wD-FtnzR6g$>

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