[Ace-analysis] Air pollution abstract - comments by 11/29

Mon Nov 28 17:26:23 EST 2022

Nice work Irena! It is nice to see this data pulled together.

With regards to the revised abstract you sent, I only had one minor suggestion. I didn't see a statement about how many children with ASD there are in your sample or how many with ASD ended up in each class. You stated that most were in the low volume class but is not clear whether the percentages refer just to children with ASD or to all children in the sample. My guess is all given the n's but since your focus is on autism, I would make the explicit.

Thanks for including me!

Tanya

Tanya St. John, Ph.D.  (she/her)

Licensed Clinical Psychologist

Research Scientist

Department of Speech and Hearing Sciences

University of Washington Autism Center

CHDD Box 357920

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We are recruiting infants from 0-6 months of age with Down Syndrome or with a sibling with autism for the Infant Brain Imaging Study. Learn more about the studies here<https://www.ibis-network.org/index.html>.

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________________________________
From: ace-analysis-bounces at bic.mni.mcgill.ca <ace-analysis-bounces at bic.mni.mcgill.ca> on behalf of Piven, Joseph <jpiven at med.unc.edu>
Sent: Monday, November 28, 2022 2:02 PM
To: Girault, Jessica B. <jessica_girault at med.unc.edu>; ace-project at bic.mni.mcgill.ca <ace-project at bic.mni.mcgill.ca>; ace-analysis at bic.mni.mcgill.ca <ace-analysis at bic.mni.mcgill.ca>
Cc: Irena Steiner <igorski1 at jhu.edu>
Subject: Re: [Ace-analysis] Air pollution abstract - comments by 11/29

So good to see this work moving forward.

A few thoughts:

  1.  In the title, ‘Autism Spectrum Disorder in Infants’ may be a bit misleading and also forfeits your opportunity to make the point it is prior to consolidation of diagnosis.  If you need space, you might cut ‘Total Tissue’ and use ‘Brain Volume Trajectories’.
  2.  Same comment in the Background – growth rates during infancy in those with and without ASD is a bit misleading.  ‘at risk’ for ASD seems to go hand in hand with a study of risk from AP exposure, as far as timing.  Has the association between AP and brain volume been with increased or decreased volume.  I thought it was the latter.
  3.  Results:  maybe change ‘we discovered’ to ‘we observed’.  ‘Higher residential …  ‘H’ should not be caps.
  4.  Conclusion:  I don’t think the results contrast with previous observations of rain enlargement in ASD.  We always knew it was only in a subset. And that ASD is heterogeneous.  I would probably take out that line and instead frame it as these results may serve to tease apart phenotypes related to the well known underlying heterogeneous (genetic and environmental) etiologic contributors.

jp

From: ace-analysis-bounces at bic.mni.mcgill.ca <ace-analysis-bounces at bic.mni.mcgill.ca> On Behalf Of Girault, Jessica B.
Sent: Wednesday, November 23, 2022 8:34 AM
To: ace-project at bic.mni.mcgill.ca; ace-analysis at bic.mni.mcgill.ca
Cc: Irena Steiner <igorski1 at jhu.edu>
Subject: [Ace-analysis] Air pollution abstract - comments by 11/29

Dear Colleagues,

Heather Volk's team has an abstract for ISEE NAC describing analyses of pollution data in relation to brain volumes.

Please see attached and provide and feedback to Irena, the first author (copied here), by 11/29.

If you would like to be included as an author, please let her know.

Thank you,

Jessica

_____________________________________

Jessica B. Girault, PhD

Assistant Professor

Carolina Institute for Developmental Disabilities

Department of Psychiatry

University of North Carolina at Chapel Hill

https://giraultlab.unc.edu/<https://urldefense.com/v3/__https://giraultlab.unc.edu/__;!!K-Hz7m0Vt54!j7k7SfN_Sylft29NwOu12FhLBjttLRuF6LjO4hBAVIntomDr0RjO_SZUmBPK4CQ4ovbd90J2wD-FtnzR6g$>

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