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Nice work Irena! It is nice to see this data pulled together. </div>
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<div class="elementToProof"><span style="font-size: 12pt; margin: 0px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);">With regards to the revised abstract you sent, I only had one minor suggestion. I didn't see a statement about how many children
with ASD there are in your sample or how many with ASD ended up in each class. You stated that most were in the low volume class but is not clear whether the percentages refer just to children with ASD or to all children in the sample. My guess is all given
the n's but since your focus is on autism, I would make the explicit. </span><br>
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<div class="elementToProof"><span style="font-size: 12pt; margin: 0px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0);">Thanks for including me! </span></div>
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Tanya</div>
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<div id="divRplyFwdMsg" dir="ltr"><font face="Calibri, sans-serif" style="font-size:11pt" color="#000000"><b>From:</b> ace-analysis-bounces@bic.mni.mcgill.ca <ace-analysis-bounces@bic.mni.mcgill.ca> on behalf of Piven, Joseph <jpiven@med.unc.edu><br>
<b>Sent:</b> Monday, November 28, 2022 2:02 PM<br>
<b>To:</b> Girault, Jessica B. <jessica_girault@med.unc.edu>; ace-project@bic.mni.mcgill.ca <ace-project@bic.mni.mcgill.ca>; ace-analysis@bic.mni.mcgill.ca <ace-analysis@bic.mni.mcgill.ca><br>
<b>Cc:</b> Irena Steiner <igorski1@jhu.edu><br>
<b>Subject:</b> Re: [Ace-analysis] Air pollution abstract - comments by 11/29</font>
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<p class="x_MsoNormal"><span style="font-size:12.0pt">So good to see this work moving forward.</span></p>
<p class="x_MsoNormal"><span style="font-size:12.0pt">A few thoughts:</span></p>
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<li class="x_MsoListParagraph" style="margin-left:0in"><span style="font-size:12.0pt">In the title, ‘Autism Spectrum Disorder in Infants’ may be a bit misleading and also forfeits your opportunity to make the point it is prior to consolidation of diagnosis.
If you need space, you might cut ‘Total Tissue’ and use ‘Brain Volume Trajectories’.</span></li><li class="x_MsoListParagraph" style="margin-left:0in"><span style="font-size:12.0pt">Same comment in the Background – growth rates during infancy in those with and without ASD is a bit misleading. ‘at risk’ for ASD seems to go hand in hand with a study of
risk from AP exposure, as far as timing. Has the association between AP and brain volume been with increased or decreased volume. I thought it was the latter.</span></li><li class="x_MsoListParagraph" style="margin-left:0in"><span style="font-size:12.0pt">Results: maybe change ‘we discovered’ to ‘we observed’. ‘Higher residential … ‘H’ should not be caps.
</span></li><li class="x_MsoListParagraph" style="margin-left:0in"><span style="font-size:12.0pt">Conclusion: I don’t think the results contrast with previous observations of rain enlargement in ASD. We always knew it was only in a subset. And that ASD is heterogeneous.
I would probably take out that line and instead frame it as these results may serve to tease apart phenotypes related to the well known underlying heterogeneous (genetic and environmental) etiologic contributors.</span></li></ol>
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<p class="x_MsoNormal" style="margin-left:.25in"><span style="font-size:12.0pt">jp</span></p>
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<p class="x_MsoNormal"><b>From:</b> ace-analysis-bounces@bic.mni.mcgill.ca <ace-analysis-bounces@bic.mni.mcgill.ca>
<b>On Behalf Of </b>Girault, Jessica B.<br>
<b>Sent:</b> Wednesday, November 23, 2022 8:34 AM<br>
<b>To:</b> ace-project@bic.mni.mcgill.ca; ace-analysis@bic.mni.mcgill.ca<br>
<b>Cc:</b> Irena Steiner <igorski1@jhu.edu><br>
<b>Subject:</b> [Ace-analysis] Air pollution abstract - comments by 11/29</p>
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<p class="x_MsoNormal" style="background:white"><span style="font-size:12.0pt; color:black">Dear Colleagues, </span></p>
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<p class="x_MsoNormal" style="background:white"><span style="font-size:12.0pt; color:black">Heather Volk's team has an abstract for ISEE NAC describing analyses of pollution data in relation to brain volumes. </span></p>
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<p class="x_MsoNormal" style="background:white"><b><span style="font-size:12.0pt; color:black">Please see attached and provide and feedback to Irena, the first author (copied here), by 11/29. </span></b><span style="font-size:12.0pt; color:black"></span></p>
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<p class="x_MsoNormal" style="background:white"><span style="font-size:12.0pt; color:black">If you would like to be included as an author, please let her know. </span></p>
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<p class="x_MsoNormal" style="background:white"><span style="font-size:12.0pt; color:black">Thank you, </span></p>
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<p class="x_MsoNormal" style="background:white"><span style="font-size:12.0pt; color:black">Jessica</span></p>
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<p><span style="font-size:10.0pt; color:black">_____________________________________</span><span style="font-size:12.0pt; color:black"></span></p>
<p><span style="font-size:10.0pt; color:black">Jessica B. Girault, PhD</span><span style="font-size:12.0pt; color:black"></span></p>
<p><span style="font-size:10.0pt; color:black">Assistant Professor</span><span style="font-size:12.0pt; color:black"></span></p>
<p><span style="font-size:10.0pt; color:black">Carolina Institute for Developmental Disabilities</span><span style="font-size:12.0pt; color:black"></span></p>
<p><span style="font-size:10.0pt; color:black">Department of Psychiatry</span><span style="font-size:12.0pt; color:black"></span></p>
<p><span style="font-size:10.0pt; color:black">University of North Carolina at Chapel Hill</span><span style="font-size:12.0pt; color:black"></span></p>
<p><span style="font-size:10.0pt; color:black"><a href="https://urldefense.com/v3/__https://giraultlab.unc.edu/__;!!K-Hz7m0Vt54!j7k7SfN_Sylft29NwOu12FhLBjttLRuF6LjO4hBAVIntomDr0RjO_SZUmBPK4CQ4ovbd90J2wD-FtnzR6g$"><span style="background:white">https://giraultlab.unc.edu/</span></a></span><span style="font-size:12.0pt; color:black"></span></p>
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