[Ace-analysis] [Ace-project] Air pollution abstract - comments by 11/29

[Casey Burrows]

Hi Irena, Heather and crew,

This is fantastic - very interesting use of this data, and interesting to
see the air pollution data contributing to brain volume growth. I had a few
questions/comments - this would pertain more to the full project as you are
writing it up.
-Why did you conduct a latent class analysis, rather than modeling growth
over time across the full sample? It seems like it would be simpler to
start by modeling individuals' growth over time, and then predict that with
your covariates of interest. Especially when the LPA suggested a "low",
"medium" and "high" group - to me that's saying that it might be better to
model it continuously.
-Did income and/or race/ethnicity covary with air pollution? How does
including that impact your results?
-If you do end up with the LPA model, would it make sense to consider a
mediation approach where air pollution --> brain growth --> ASD outcome? To
me that conceptually fits with the model you're proposing. But it also
sounds very complicated to model...

Really interesting work!
Casey

On Wed, Nov 23, 2022 at 10:26 AM Annette Estes <estesa at uw.edu> wrote:

> This is great!  So happy to see the outcomes of this data collection
> effort.  One thought – if you have the words available, it would be good to
> further discuss the implications of these findings, rather than stopping at
> “this contrasts with observations of brain enlargement….”.
>
>
>
> Thanks for your work on this!! Annette
>
>
>
> *From:* ace-project-bounces at bic.mni.mcgill.ca <
> ace-project-bounces at bic.mni.mcgill.ca> *On Behalf Of *Girault, Jessica B.
> *Sent:* Wednesday, November 23, 2022 5:34 AM
> *To:* ace-project at bic.mni.mcgill.ca; ace-analysis at bic.mni.mcgill.ca
> *Cc:* Heather Volk <hvolk1 at jhu.edu>; Irena Steiner <igorski1 at jhu.edu>
> *Subject:* [Ace-project] Air pollution abstract - comments by 11/29
>
>
>
> Dear Colleagues,
>
>
>
> Heather Volk's team has an abstract for ISEE NAC describing analyses of
> pollution data in relation to brain volumes.
>
>
>
> *Please see attached and provide and feedback to Irena, the first author
> (copied here), by 11/29. *
>
>
>
> If you would like to be included as an author, please let her know.
>
>
>
> Thank you,
>
>
>
> Jessica
>
>
>
>
>
> _____________________________________
>
> Jessica B. Girault, PhD
>
> Assistant Professor
>
> Carolina Institute for Developmental Disabilities
>
> Department of Psychiatry
>
> University of North Carolina at Chapel Hill
>
> https://giraultlab.unc.edu/
> <https://urldefense.com/v3/__https:/giraultlab.unc.edu/__;!!K-Hz7m0Vt54!nLi2kofkvGRWcZoasRXsZYHt2kITkMg13bp7KkfFvpPscqea98GoHOss2OB1HNqyjnAGtvhRiqeRaxJN14Q0bvopyNQ$>
>
>
> _______________________________________________
> Ace-project mailing list
> Ace-project at bic.mni.mcgill.ca
> https://mailman.bic.mni.mcgill.ca/mailman/listinfo/ace-project
>


-- 
-----
Casey Burrows, PhD, LP
Assistant Professor of Pediatrics
University of Minnesota
Autism and Neurodevelopment Clinic
Ph: 612-626-3834
Fax: 612-365-9050
Pronouns: she/her/hers

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