<div dir="ltr">Hi Irena, Heather and crew,<div><br></div><div>This is fantastic - very interesting use of this data, and interesting to see the air pollution data contributing to brain volume growth. I had a few questions/comments - this would pertain more to the full project as you are writing it up. </div><div>-Why did you conduct a latent class analysis, rather than modeling growth over time across the full sample? It seems like it would be simpler to start by modeling individuals' growth over time, and then predict that with your covariates of interest. Especially when the LPA suggested a "low", "medium" and "high" group - to me that's saying that it might be better to model it continuously.</div><div>-Did income and/or race/ethnicity covary with air pollution? How does including that impact your results?</div><div>-If you do end up with the LPA model, would it make sense to consider a mediation approach where air pollution --> brain growth --> ASD outcome? To me that conceptually fits with the model you're proposing. But it also sounds very complicated to model... </div><div><br></div><div>Really interesting work! </div><div>Casey</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Wed, Nov 23, 2022 at 10:26 AM Annette Estes <<a href="mailto:estesa@uw.edu">estesa@uw.edu</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div class="msg4545804377542816805">
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<p class="MsoNormal">This is great! So happy to see the outcomes of this data collection effort. One thought – if you have the words available, it would be good to further discuss the implications of these findings, rather than stopping at “this contrasts
with observations of brain enlargement….”. <u></u><u></u></p>
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<p class="MsoNormal">Thanks for your work on this!! Annette<u></u><u></u></p>
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<p class="MsoNormal"><b>From:</b> <a href="mailto:ace-project-bounces@bic.mni.mcgill.ca" target="_blank">ace-project-bounces@bic.mni.mcgill.ca</a> <<a href="mailto:ace-project-bounces@bic.mni.mcgill.ca" target="_blank">ace-project-bounces@bic.mni.mcgill.ca</a>>
<b>On Behalf Of </b>Girault, Jessica B.<br>
<b>Sent:</b> Wednesday, November 23, 2022 5:34 AM<br>
<b>To:</b> <a href="mailto:ace-project@bic.mni.mcgill.ca" target="_blank">ace-project@bic.mni.mcgill.ca</a>; <a href="mailto:ace-analysis@bic.mni.mcgill.ca" target="_blank">ace-analysis@bic.mni.mcgill.ca</a><br>
<b>Cc:</b> Heather Volk <<a href="mailto:hvolk1@jhu.edu" target="_blank">hvolk1@jhu.edu</a>>; Irena Steiner <<a href="mailto:igorski1@jhu.edu" target="_blank">igorski1@jhu.edu</a>><br>
<b>Subject:</b> [Ace-project] Air pollution abstract - comments by 11/29<u></u><u></u></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:12pt;color:black">Dear Colleagues, <u></u><u></u></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:12pt;color:black">Heather Volk's team has an abstract for ISEE NAC describing analyses of pollution data in relation to brain volumes. <u></u><u></u></span></p>
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<p class="MsoNormal" style="background:white"><b><span style="font-size:12pt;color:black">Please see attached and provide and feedback to Irena, the first author (copied here), by 11/29. </span></b><span style="font-size:12pt;color:black"><u></u><u></u></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:12pt;color:black">If you would like to be included as an author, please let her know. <u></u><u></u></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:12pt;color:black">Thank you, <u></u><u></u></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:12pt;color:black"><u></u> <u></u></span></p>
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<p class="MsoNormal" style="background:white"><span style="font-size:12pt;color:black">Jessica<u></u><u></u></span></p>
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<p><span style="font-size:10pt;color:black">_____________________________________</span><span style="font-size:12pt;color:black"><u></u><u></u></span></p>
<p><span style="font-size:10pt;color:black">Jessica B. Girault, PhD</span><span style="font-size:12pt;color:black"><u></u><u></u></span></p>
<p><span style="font-size:10pt;color:black">Assistant Professor</span><span style="font-size:12pt;color:black"><u></u><u></u></span></p>
<p><span style="font-size:10pt;color:black">Carolina Institute for Developmental Disabilities</span><span style="font-size:12pt;color:black"><u></u><u></u></span></p>
<p><span style="font-size:10pt;color:black">Department of Psychiatry</span><span style="font-size:12pt;color:black"><u></u><u></u></span></p>
<p><span style="font-size:10pt;color:black">University of North Carolina at Chapel Hill</span><span style="font-size:12pt;color:black"><u></u><u></u></span></p>
<p><span style="font-size:10pt;color:black"><a href="https://urldefense.com/v3/__https:/giraultlab.unc.edu/__;!!K-Hz7m0Vt54!nLi2kofkvGRWcZoasRXsZYHt2kITkMg13bp7KkfFvpPscqea98GoHOss2OB1HNqyjnAGtvhRiqeRaxJN14Q0bvopyNQ$" target="_blank"><span style="background:white">https://giraultlab.unc.edu/</span></a></span><span style="font-size:12pt;color:black"><u></u><u></u></span></p>
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</div></blockquote></div><br clear="all"><div><br></div>-- <br><div dir="ltr" class="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div style="color:rgb(0,0,0);font-family:Calibri,Helvetica,sans-serif;font-size:16px;margin:0px"><font face="Cambria,serif" size="1" color="#595959"><span style="font-size:13.32px">-----</span></font></div><div style="color:rgb(0,0,0);font-family:Calibri,Helvetica,sans-serif;font-size:16px;margin:0px"><font face="Cambria,serif" size="1" color="#595959"><span style="font-size:13.32px">Casey Burrows, PhD, LP<br></span></font><span style="color:rgb(89,89,89);font-family:Cambria,serif;font-size:13.32px">Assistant Professor of Pediatrics</span></div><div style="color:rgb(0,0,0);font-family:Calibri,Helvetica,sans-serif;font-size:16px;margin:0px"><font face="Cambria,serif" size="1" color="#595959"><span style="font-size:13.32px">University of Minnesota</span></font></div><div style="color:rgb(0,0,0);font-family:Calibri,Helvetica,sans-serif;font-size:16px;margin:0px"><font face="Cambria,serif" size="1" color="#595959"><span style="font-size:13.32px">Autism and Neurodevelopment Clinic</span></font></div><div style="margin:0px"><font color="#595959" face="Cambria, serif"><span style="font-size:13.32px">Ph: 612-626-3834</span></font></div><div style="margin:0px"><font color="#595959" face="Cambria, serif"><span style="font-size:13.32px">Fax: 612-365-9050</span></font></div><div style="margin:0px"><font color="#595959" face="Cambria, serif"><span style="font-size:13.32px">Pronouns: she/her/hers</span></font></div><div style="margin:0px"><font color="#595959" face="Cambria, serif"><span style="font-size:13.32px"><br></span></font></div><div style="color:rgb(0,0,0);font-family:Calibri,Helvetica,sans-serif;font-size:16px;margin:0px"><span style="color:rgb(51,51,51);font-family:Arial,Helvetica,sans-serif;font-size:12px">Note: The information transmitted in this e-mail is intended only for the person or entity to which it is addressed and may contain confidential and/or privileged material, including "protected health information." If you are not the intended recipient, you are hereby notified that any review, retransmission, dissemination, distribution, or copying of this message is strictly prohibited. If you have received this communication in error, please destroy and delete this message from any computer and contact us immediately by return e-mail.</span><font face="Cambria,serif" size="1" color="#595959"><span style="font-size:13.32px"><br></span></font></div></div></div></div></div></div></div></div></div></div>