[BIC-announce] Fwd: (REMINDER): Neuro Event: April 14, 4PM EDT - Feindel Virtual Brain and Mind Seminar "The locus coeruleus-noradrenaline system in Parkinson's disease"

Wed Apr 14 13:02:54 EDT 2021

FYI
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From: NeuroEvents <events.neuro at MCGILL.CA>
Date: Apr 14, 2021, 1:01 PM -0400
To: MNISTAFF at LISTS.MCGILL.CA <MNISTAFF at LISTS.MCGILL.CA>
Subject: (REMINDER): Neuro Event: April 14, 4PM EDT - Feindel Virtual Brain and Mind Seminar "The locus coeruleus-noradrenaline system in Parkinson's disease"

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[Text Description automatically generated with medium confidence]

Wednesday, April 14, 2021
4:00 - 5:00PM EDT
Zoom Registration Required<https://www.eventbrite.ca/e/feindel-virtual-brain-and-mind-seminar-tickets-148777907727>

Livestreaming through Vimeo<https://vimeo.com/event/269074>
Speaker: Claire O’Callaghan, PhD<https://scholar.google.com.au/citations?hl=en&user=a0SO9nEAAAAJ&view_op=list_works>
Research Fellow, Faculty of Medicine, University of Sydney, Australia

Abstract
The locus coeruleus–noradrenaline system plays an extensive role in cognition and behaviour. Understanding how this system is impacted by disease has important implications for treatment, and can offer insights into how the system functions in the healthy brain. My talk will focus on the locus coeruleus–noradrenaline system in Parkinson’s disease – in particular, the role it plays in impulsivity and reinforcement learning. Using a combined approach, we characterised the locus coeruleus using 7T MRI and probed the system in a pharmacological study with the noradrenergic reuptake inhibitor atomoxetine. Following on from extensive preclinical work linking stop-signal inhibition to the noradrenergic system, we show that stop-signal task performance is modulated by atomoxetine and dependent on locus coeruleus integrity. We also use this framework to further confirm a role for noradrenaline in navigating uncertainty during reinforcement learning, by showing improved learning behaviour under atomoxetine via computational modelling and pupillometry. Together, these findings advance ideas around noradrenergic therapy in Parkinson’s disease and hopefully provide some new insights into how the locus coeruleus–noradrenaline system orchestrates human behaviour.

The Feindel Virtual Brain and Mind (VBM) Seminar Series
Advancing the vision of Dr. William Feindel (1918–2014), former Director of the Neuro (1972–1984) and Founding Director of the McConnell Brain Imaging Centre (1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.

Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brainand cognitive disorders. If you, or someone you know, would be interested in presenting please contact us to secure a spot on the schedule.

Looking forward to reconnecting!

Nathan Spreng
Boris Bernhardt
Bratislav Misic

To register: Eventbrite<https://www.eventbrite.ca/e/feindel-virtual-brain-and-mind-seminar-tickets-148777907727>

Contact : Sasha Kelly<mailto:sasha.kelly at mcgill.ca>, Events and Conference Coordinator, The Neuro

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