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<div dir="auto"><span style="font-family:Al Nile;font-size: 9px">FYI </span></div>
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<div name="messageReplySection">---------- Forwarded message ----------<br>
<b>From:</b> NeuroEvents <events.neuro@MCGILL.CA><br>
<b>Date:</b> Apr 14, 2021, 1:01 PM -0400<br>
<b>To:</b> MNISTAFF@LISTS.MCGILL.CA <MNISTAFF@LISTS.MCGILL.CA><br>
<b>Subject:</b> (REMINDER): Neuro Event: April 14, 4PM EDT - Feindel Virtual Brain and Mind Seminar "The locus coeruleus-noradrenaline system in Parkinson's disease"<br>
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<p><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:blue"><a href="https://mcgill.ca/neuro/" target="_blank" title="https://mcgill.ca/neuro/"><span style="color:blue;text-decoration:none"><br>
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<p><span style="font-size:10.0pt;font-family:"Times New Roman",serif;color:blue"><a href="https://ca.linkedin.com/company/the-montreal-neurological-institute" target="_blank"><span style="color:blue;text-decoration:none"><img border="0" width="44" height="44" style="width:.4583in;height:.4583in" id="Picture_x0020_6" src="cid:image005.png@01D7312B.F8AF45F0" alt="cidimage005.png@01D7044C.A9F2B480"></span></a></span></p>
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<p style="text-align:justify"><b><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black">Wednesday, April 14, 2021<br>
4:00 - 5:00PM</span></b><b><span style="font-size:13.5pt;font-family:"Arial",sans-serif"> EDT<span style="color:black"><br>
Zoom</span><span style="color:#1F497D"> <a href="https://www.eventbrite.ca/e/feindel-virtual-brain-and-mind-seminar-tickets-148777907727" target="_blank" title="https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-128284916639">Registration
Required</a></span></span></b></p>
<p style="text-align:justify"><b><span style="font-size:13.5pt;font-family:"Arial",sans-serif">Livestreaming through <a href="https://vimeo.com/event/269074" target="_blank"><span style="color:#954F72">Vimeo</span></a></span></b></p>
<p class="MsoNormal"><b><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black">Speake</span></b><b><span style="font-size:13.5pt;font-family:"Arial",sans-serif">r:
<a href="https://scholar.google.com.au/citations?hl=en&user=a0SO9nEAAAAJ&view_op=list_works">
Claire O’Callaghan, PhD</a><br>
</span></b><span style="font-family:"Arial",sans-serif">Research Fellow, Faculty of Medicine, University of Sydney, Australia</span></p>
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<p class="MsoNormal"><strong><span style="font-family:"Arial",sans-serif;color:black;background:white">Abstract</span></strong></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">The locus coeruleus–noradrenaline system plays an extensive role in cognition and behaviour. Understanding how this system is impacted by disease has important implications
for treatment, and can offer insights into how the system functions in the healthy brain. My talk will focus on the locus coeruleus–noradrenaline system in Parkinson’s disease – in particular, the role it plays in impulsivity and reinforcement learning. Using
a combined approach, we characterised the locus coeruleus using 7T MRI and probed the system in a pharmacological study with the noradrenergic reuptake inhibitor atomoxetine. Following on from extensive preclinical work linking stop-signal inhibition to the
noradrenergic system, we show that stop-signal task performance is modulated by atomoxetine and dependent on locus coeruleus integrity. We also use this framework to further confirm a role for noradrenaline in navigating uncertainty during reinforcement learning,
by showing improved learning behaviour under atomoxetine via computational modelling and pupillometry. Together, these findings advance ideas around noradrenergic therapy in Parkinson’s disease and hopefully provide some new insights into how the locus coeruleus–noradrenaline
system orchestrates human behaviour.</span></p>
<p style="text-align:justify;line-height:15.0pt"><strong><span style="font-family:"Arial",sans-serif;color:black">The</span></strong><span class="apple-converted-space"><b><span style="font-family:"Arial",sans-serif;color:black"> </span></b></span><strong><span style="font-family:"Arial",sans-serif;color:black">Feindel</span></strong><span class="apple-converted-space"><b><span style="font-family:"Arial",sans-serif;color:black"> </span></b></span><strong><span style="font-family:"Arial",sans-serif;color:black">Virtual</span></strong><span class="apple-converted-space"><b><span style="font-family:"Arial",sans-serif;color:black"> </span></b></span><strong><span style="font-family:"Arial",sans-serif;color:black">Brain</span></strong><span class="apple-converted-space"><b><span style="font-family:"Arial",sans-serif;color:black"> </span></b></span><strong><span style="font-family:"Arial",sans-serif;color:black">and</span></strong><span class="apple-converted-space"><b><span style="font-family:"Arial",sans-serif;color:black"> </span></b></span><strong><span style="font-family:"Arial",sans-serif;color:black">Mind</span></strong><span class="apple-converted-space"><b><span style="font-family:"Arial",sans-serif;color:black"> </span></b></span><strong><span style="font-family:"Arial",sans-serif;color:black">(VBM)
Seminar Series</span></strong><span style="font-family:"Arial",sans-serif;color:black"><br>
Advancing the vision of Dr. William<span class="apple-converted-space"> </span>Feindel<span class="apple-converted-space"> </span>(1918–2014), former Director of the Neuro (1972–1984)<span class="apple-converted-space"> </span>and<span class="apple-converted-space"> </span>Founding
Director of the McConnell<span class="apple-converted-space"> </span>Brain<span class="apple-converted-space"> </span>Imaging Centre (1984), to constantly bridge the clinical<span class="apple-converted-space"> </span>and<span class="apple-converted-space"> </span>research
realms. The talks will highlight the latest advances<span class="apple-converted-space"> </span>and<span class="apple-converted-space"> </span>discoveries in neuropsychology, cognitive neuroscience,<span class="apple-converted-space"> </span>and<span class="apple-converted-space"> </span>neuroimaging.</span></p>
<p style="text-align:justify;line-height:15.0pt"><span style="font-family:"Arial",sans-serif;color:black">Speakers will include scientists from across The Neuro, as well as colleagues<span class="apple-converted-space"> </span>and<span class="apple-converted-space"> </span>collaborators
locally<span class="apple-converted-space"> </span>and<span class="apple-converted-space"> </span>from around the world. The series is intended to provide a<span class="apple-converted-space"> </span>virtual<span class="apple-converted-space"> </span>forum
for scientists<span class="apple-converted-space"> </span>and<span class="apple-converted-space"> </span>trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis<span class="apple-converted-space"> </span>and<span class="apple-converted-space"> </span>treatment
of<span class="apple-converted-space"> </span>brainand<span class="apple-converted-space"> </span>cognitive disorders. If you, or someone you know, would be interested in presenting please contact us to secure a spot on the schedule.</span></p>
<p style="text-align:justify;line-height:15.0pt"><span style="font-family:"Arial",sans-serif;color:black">Looking forward to reconnecting!</span></p>
<p style="text-align:justify;line-height:15.0pt"><span style="font-family:"Arial",sans-serif;color:black">Nathan Spreng<br>
Boris Bernhardt<br>
Bratislav Misic </span></p>
<p style="text-align:justify;line-height:15.0pt"><strong><span style="font-family:"Arial",sans-serif;color:black">To register:</span></strong><span style="font-family:"Times New Roman",serif"><a href="https://www.eventbrite.ca/e/feindel-virtual-brain-and-mind-seminar-tickets-148777907727" target="_blank" title="https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-128284916639"> <span style="font-family:"Arial",sans-serif">Eventbrite</span></a></span></p>
<p style="text-align:justify;line-height:15.0pt"><strong><span style="font-family:"Arial",sans-serif;color:black">Contact :</span></strong><span style="font-family:"Arial",sans-serif;color:black"> <a href="mailto:sasha.kelly@mcgill.ca" target="_blank"><span style="color:#954F72">Sasha
Kelly</span></a>, Events</span><span class="apple-converted-space"><span style="font-family:"Arial",sans-serif"> </span></span><span style="font-family:"Arial",sans-serif">and<span class="apple-converted-space"> </span>Conference<span class="apple-converted-space"><span style="color:black"> </span></span><span style="color:black">Coordinator</span>,
The Neuro</span></p>
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