[BIC-announce] Fwd: [NEURO] (Reminder) Neuro Event: November 18, 4:00 pm - Feindel Virtual Brain and Mind Seminar: “Measuring brain integrity using MRI: A novel biomarker for Alzheimer’s disease using T2 relaxometry”

Wed Nov 18 10:28:46 EST 2020

Hi BIC & FYI -

Begin forwarded message:

From: NeuroEvents <events.neuro at MCGILL.CA<mailto:events.neuro at MCGILL.CA>>
Subject: [NEURO] (Reminder) Neuro Event: November 18, 4:00 pm - Feindel Virtual Brain and Mind Seminar: “Measuring brain integrity using MRI: A novel biomarker for Alzheimer’s disease using T2 relaxometry”
Date: November 17, 2020 at 9:48:11 AM GMT-5
To: <NEURO at LISTS.MCGILL.CA<mailto:NEURO at LISTS.MCGILL.CA>>
Reply-To: NeuroEvents <events.neuro at MCGILL.CA<mailto:events.neuro at MCGILL.CA>>

[cid:image001.png at 01D6BCC6.BF0412B0]<https://mcgill.ca/neuro/>
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[cid:image008.png at 01D6BCC6.BF0412B0]
Wednesday, November 18, 2020
4:00 - 5:00PM EDT
Zoom Registration Required<https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-128284916639>
Livestreaming through Vimeo<https://vimeo.com/event/269074>
Speaker: Alfie Wearn, PhD<http://www.bristol.ac.uk/neural-dynamics/people/alfie-r-wearn/index.html>
Institute of Clinical Neurosciences, University of Bristol, UK
Talk abstract
In neurodegenerative diseases, such as Alzheimer’s disease, it is important to identify damage to the brain as quickly as possible before irreversible damage has occurred. My work shows that magnetic resonance imaging (MRI) may be even better at detecting damage to the brain than we thought - if we only look at the data in the right way.

Prior to significant brain tissue atrophy, several microstructural changes take place as a result of Alzheimer’s pathology. These include deposition of amyloid, tau and iron, as well as altered water homeostasis in tissue and some cell death. T2 relaxation time, a quantitative MRI measure, is sensitive to these changes and may be a useful non-invasive, early marker of tissue integrity which could predict conversion to dementia. I propose that different microstructural changes affect T2 in opposing ways, such that average ‘midpoint’ measures of T2 are less sensitive than measuring distribution width (heterogeneity). T2 heterogeneity in the brain may present a sensitive early marker of AD pathology.

In this talk I will summarize findings from my recently completed PhD studies, in which I explored the clinical utility of T2 heterogeneity in older people with and without cognitive impairment. I will present a model of early changes in T2 in the medial temporal lobe that considers the competing effects of factors that both increase and decrease T2.

The Feindel Virtual Brain and Mind (VBM) Seminar Series
Advancing the vision of Dr. William Feindel (1918–2014), former Director of the Neuro (1972–1984) and Founding Director of the McConnell Brain Imaging Centre (1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.

Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders. If you, or someone you know, would be interested in presenting please contact us to secure a spot on the schedule.

Looking forward to reconnecting!

Nathan Spreng
Boris Bernhardt
Bratislav Misic

To register: Eventbrite<https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-128284916639>

Contact : Sasha Kelly<mailto:sasha.kelly at mcgill.ca>, Events Coordinator

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