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Hi BIC & FYI - <br class="">
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<span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">From:
</b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">NeuroEvents <<a href="mailto:events.neuro@MCGILL.CA" class="">events.neuro@MCGILL.CA</a>><br class="">
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<span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Subject:
</b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><b class="">[NEURO] (Reminder) Neuro Event: November 18, 4:00 pm - Feindel Virtual Brain and Mind Seminar: “Measuring brain integrity using MRI: A novel
biomarker for Alzheimer’s disease using T2 relaxometry”</b><br class="">
</span></div>
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<span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Date:
</b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">November 17, 2020 at 9:48:11 AM GMT-5<br class="">
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<span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">To:
</b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><<a href="mailto:NEURO@LISTS.MCGILL.CA" class="">NEURO@LISTS.MCGILL.CA</a>><br class="">
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<span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Reply-To:
</b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">NeuroEvents <<a href="mailto:events.neuro@MCGILL.CA" class="">events.neuro@MCGILL.CA</a>><br class="">
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<div class=""><b class=""><span style="font-size: 13.5pt; font-family: Arial, sans-serif;" class="">Wednesday, November 18, 2020</span></b><b class=""><span style="font-size: 13.5pt; font-family: Arial, sans-serif;" class=""> <span style="" class=""><br class="">
4:00 - 5:00PM</span> EDT<span style="" class=""><br class="">
Zoom</span><span style="color: rgb(31, 73, 125);" class=""> <a href="https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-128284916639" target="_blank" title="https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-128284916639" style="color: blue; text-decoration: underline;" class="">Registration
Required</a></span></span></b><o:p class=""></o:p></div>
<div class=""><b class=""><span style="font-size: 13.5pt; font-family: Arial, sans-serif;" class="">Livestreaming through <a href="https://vimeo.com/event/269074" target="_blank" style="color: blue; text-decoration: underline;" class=""><span style="color: rgb(149, 79, 114);" class="">Vimeo</span></a></span></b><o:p class=""></o:p></div>
<div class=""><b class=""><span style="font-size: 13.5pt; font-family: Arial, sans-serif;" class="">Speake</span></b><b class=""><span style="font-size: 13.5pt; font-family: Arial, sans-serif;" class="">r:<span class="Apple-converted-space"> </span><a href="http://www.bristol.ac.uk/neural-dynamics/people/alfie-r-wearn/index.html" style="color: blue; text-decoration: underline;" class="">Alfie
Wearn, PhD</a><br class="">
</span></b><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Institute of Clinical Neurosciences, University of Bristol, UK</span><o:p class=""></o:p></div>
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<b class=""><span style="font-size: 10.5pt; line-height: 16.100000381469727px; font-family: Arial, sans-serif;" class="">Talk abstract</span></b><o:p class=""></o:p></div>
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<span style="font-size: 10.5pt; line-height: 16.100000381469727px; font-family: Arial, sans-serif;" class="">In neurodegenerative diseases, such as Alzheimer’s disease, it is important to identify damage to the brain as quickly as possible before irreversible
damage has occurred. My work shows that magnetic resonance imaging (MRI) may be even better at detecting damage to the brain than we thought - if we only look at the data in the right way.</span><span style="font-size: 10.5pt; line-height: 16.100000381469727px;" class=""></span><o:p class=""></o:p></div>
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<span style="font-size: 10.5pt; line-height: 16.100000381469727px; font-family: Arial, sans-serif;" class="">Prior to significant brain tissue atrophy, several microstructural changes take place as a result of Alzheimer’s pathology. These include deposition
of amyloid, tau and iron, as well as altered water homeostasis in tissue and some cell death. T2 relaxation time, a quantitative MRI measure, is sensitive to these changes and may be a useful non-invasive, early marker of tissue integrity which could predict
conversion to dementia. I propose that different microstructural changes affect T2 in opposing ways, such that average ‘midpoint’ measures of T2 are less sensitive than measuring distribution width (heterogeneity). T2 heterogeneity in the brain may present
a sensitive early marker of AD pathology.</span><o:p class=""></o:p></div>
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<span style="font-size: 10.5pt; line-height: 16.100000381469727px;" class=""> </span><o:p class=""></o:p></div>
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<span style="font-size: 10.5pt; line-height: 16.100000381469727px; font-family: Arial, sans-serif;" class="">In this talk I will summarize findings from my recently completed PhD studies, in which I explored the clinical utility of T2 heterogeneity in older
people with and without cognitive impairment. I will present a model of early changes in T2 in the medial temporal lobe that considers the competing effects of factors that both increase and decrease T2.</span><span style="font-size: 10.5pt; line-height: 16.100000381469727px;" class=""></span><o:p class=""></o:p></div>
<p style="text-align: justify; line-height: 15pt;" class=""><strong class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">The Feindel Virtual Brain and Mind (VBM) Seminar Series</span></strong><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""><br class="">
Advancing the vision of Dr. William Feindel (1918–2014), former Director of the Neuro (1972–1984) and Founding Director of the McConnell Brain Imaging Centre (1984), to constantly bridge the clinical and research realms. The talks will highlight the latest
advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.</span><o:p class=""></o:p></p>
<p style="text-align: justify; line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the
world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders. If you, or someone you know, would be interested
in presenting please contact us to secure a spot on the schedule.</span><o:p class=""></o:p></p>
<p style="line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Looking forward to reconnecting!</span><o:p class=""></o:p></p>
<p style="line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Nathan Spreng<br class="">
Boris Bernhardt<br class="">
Bratislav Misic </span><o:p class=""></o:p></p>
<p style="line-height: 15pt;" class=""><strong class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">To register:</span></strong><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""> </span><span style="font-size: 10.5pt; font-family: Arial, sans-serif; color: rgb(149, 79, 114);" class=""><a href="https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-128284916639" target="_blank" title="https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-128284916639" style="color: blue; text-decoration: underline;" class="">Eventbrite</a></span><o:p class=""></o:p></p>
<p style="line-height: 15pt;" class=""><strong class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Contact :</span></strong><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""> <a href="mailto:sasha.kelly@mcgill.ca" target="_blank" style="color: blue; text-decoration: underline;" class=""><span style="color: rgb(149, 79, 114);" class="">Sasha
Kelly</span></a>, Events Coordinator </span><o:p class=""></o:p></p>
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