[BIC-announce] Reminder: MCIN lecture - Jake Vogel - This Friday, 13:00

[R. ADALAT]

>
>
> On Wed, Jan 22, 2020 at 1:14 PM Patrick Bermudez <
> patrick.bermudez at gmail.com> wrote:
>
>> Please join us in the de Grandpré auditorium Friday, the 24th of
>> January, for a lecture by Jacob Vogel entitled "Spatiotemporal
>> subtypes of Alzheimer's disease using tau-PET imaging".   Here is an
>> abstract of Jake's talk:
>>
>> -----------------
>> Alzheimer's disease (AD) is characterized by pathological aggregation
>> of two different, aberrantly conformed proteins, beta-amyloid and tau.
>> Classic pathological studies based on extensive autopsy cohorts have
>> taught us that these proteins, particularly tau, spread through the
>> cerebral cortex in a specific and highly stereotyped manner. However,
>> rare subtypes of AD with divergent patterns of tau deposition have
>> been reported and some studies have also reported variation even in
>> typical AD.
>>
>> Pathology studies suffer from limitations that make identifying
>> pathological subtypes challenging, including limited spatial sampling
>> and semi-quantitative measurement strategies. However, neuroimaging
>> subtyping studies have also been limited by non-specific measurements
>> and methodological challenges that I will discuss in detail.
>>
>> I will report the application of a novel spatiotemporal subtyping
>> approach to a large (n=1764), multisite dataset of tau-PET images. I
>> will describe the phenotypic presentation of the subtypes identified,
>> how they conform with and diverge from previous literature, and how
>> these results fit with the current models of AD pathological
>> progression.
>> -----------------
>>
>
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