[BIC-announce] Fwd: Reminder Neuro Event: April 29, 4 pm -Feindel Virtual Brain and Mind Seminar “Mapping neuropsychiatric mutation effects on functional brain connectivity to delineate dimensions contributing to autism and schizophrenia"

Mon Apr 27 16:10:13 EDT 2020

Hi BIC at Home & FYI - 


> Begin forwarded message:
> 
> From: NeuroCommunications <communications.neuro at MCGILL.CA>
> Subject: Reminder Neuro Event: April 29, 4 pm -Feindel Virtual Brain and Mind Seminar “Mapping neuropsychiatric mutation effects on functional brain connectivity to delineate dimensions contributing to autism and schizophrenia"
> Date: April 27, 2020 at 11:47:50 AM EDT
> To: <MNISTAFF at LISTS.MCGILL.CA>
> Reply-To: NeuroCommunications <communications.neuro at MCGILL.CA>
> 
>  <https://mcgill.ca/neuro/>	
>  <http://twitter.com/TheNeuro_MNI>	
>  <https://www.facebook.com/TheNeuroMNI/>	
>  <https://www.instagram.com/theneuro_mni/>	
>  <https://ca.linkedin.com/company/the-montreal-neurological-institute>	
>  <https://www.youtube.com/user/MontrealNeuro>
> 
>  
> 
> Feindel Virtual Brain and Mind Seminar at The Neuro: 
> “Mapping neuropsychiatric mutation effects on functional brain connectivity to delineate dimensions contributing to autism and schizophrenia”
> 
> Wednesday, April 29, 2020
> 4:00 - 5:00PM
> Zoom (registration required <https://www.mcgill.ca/neuro/channels/event/feindel-virtual-brain-and-mind-seminar-neuro-mapping-neuropsychiatric-mutation-effects-functional-321797>)
> 
> Speaker: Clara Moreau
> 
> Talk abstract
> Copy number variants (CNVs) are among the most highly penetrant genetic risk factors for neuropsychiatric disorders. Because they confer risk for overlapping conditions, we hypothesized that they may converge on shared connectivity patterns. We performed connectome-wide analyses using resting-state fMRI data from 502 carriers of CNVs associated to different degrees with neuropsychiatric conditions, 756 individuals with idiopathic ASD, schizophrenia, attention deficit hyperactivity disorder, and 5,377 controls. We showed that the effect size of CNVs on connectivity was correlated with the known level of clinical risk conferred by mutations. We identified similarities between connectivity profiles of high-risk mutations and the connectivity architecture of individuals with schizophrenia and autism. Similarities were driven by the thalamus, and the posterior cingulate cortex, previously identified as major hubs altered across psychiatric conditions. Because these results raised questions about shared mechanisms across CNVs, we then posited that haploinsufficiency may reorganize connectivity along general dimensions irrespective of where deletions occur in the genome. Using a continuous score to quantify the severity of deletions (pLI), we identified a connectivity profile that appears to be present in deletions irrespective of genomic location. This profile was correlated with lower general intelligence and higher autism severity scores in 3 unselected and disease cohorts. Such general brain signatures open new avenues to understand polygenicity in psychiatric conditions and the pleiotropic effect of CNVs on cognition and risk for mental illnesses.
> 
> The Feindel Virtual Brain and Mind (VBM) Seminar Series
> Advancing the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.
> 
> Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.
> If you, or someone you know, would be interested in presenting please contact us to secure a spot on the schedule.
> 
> Looking forward to reconnecting!
> 
> Nathan Spreng
> Boris Bernhardt
> Bratislav Misic 
> 
> To register: https://www.eventbrite.ca/e/feindel-virtual-brain-and-mind-seminar-at-the-neuro-presents-clara-moreau-tickets-103427999932 <https://www.eventbrite.ca/e/feindel-virtual-brain-and-mind-seminar-at-the-neuro-presents-clara-moreau-tickets-103427999932>
> Contact : Sasha Kelly, Events Coordinator, neuroevents.mni at mcgill.ca <mailto:neuroevents.mni at mcgill.ca>
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