
<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Hi BIC@Home & FYI - <div class=""><div class=""><div class=""><br class=""><div><br class=""><blockquote type="cite" class=""><div class="">Begin forwarded message:</div><br class="Apple-interchange-newline"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">From: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">NeuroCommunications <<a href="mailto:communications.neuro@MCGILL.CA" class="">communications.neuro@MCGILL.CA</a>><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Subject: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><b class="">Reminder Neuro Event: April 29, 4 pm -Feindel Virtual Brain and Mind Seminar “Mapping neuropsychiatric mutation effects on functional brain connectivity to delineate dimensions contributing to autism and schizophrenia"</b><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Date: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">April 27, 2020 at 11:47:50 AM EDT<br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">To: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><<a href="mailto:MNISTAFF@LISTS.MCGILL.CA" class="">MNISTAFF@LISTS.MCGILL.CA</a>><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Reply-To: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">NeuroCommunications <<a href="mailto:communications.neuro@MCGILL.CA" class="">communications.neuro@MCGILL.CA</a>><br class=""></span></div><br class=""><div class=""><div class="WordSection1" style="page: WordSection1; caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;"><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="0" style="width: 573.8pt;"><tbody class=""><tr class=""><td width="100%" style="width: 745.0625px; background-color: white; padding: 7.5pt 7.5pt 0in; background-position: initial initial; background-repeat: initial initial;" class=""><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="100%" style="width: 745.0625px;"><tbody class=""><tr class=""><td width="50%" valign="bottom" style="width: 384.984375px; padding: 0in;" class=""><div align="center" class=""><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="100%" style="width: 384.984375px;"><tbody class=""><tr class=""><td valign="top" style="padding: 7.5pt 7.5pt 7.5pt 0in;" class=""><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0"><tbody class=""><tr class=""><td valign="top" style="padding: 0in;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><a href="https://mcgill.ca/neuro/" title="https://mcgill.ca/neuro/" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="color: blue; text-decoration: none;" class=""><img border="0" id="Picture_x0020_11" alt="The Neuro's logo" style="" class="" apple-inline="yes" src="cid:image001.jpg@01D61C89.AC4998D0"></span></a><o:p class=""></o:p></div></td></tr></tbody></table></td></tr></tbody></table></div></td><td width="50%" valign="bottom" style="width: 360.078125px; padding: 0in;" class=""><div align="center" class=""><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="100%" style="width: 360.078125px;"><tbody class=""><tr class=""><td width="20%" valign="bottom" style="width: 52.015625px; padding: 7.5pt;" class=""></td><td valign="bottom" style="padding: 3.75pt 3.75pt 15pt;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><a href="http://twitter.com/TheNeuro_MNI" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="color: blue; text-decoration: none;" class=""><img border="0" id="Picture_x0020_10" alt="Twitter" style="" class="" apple-inline="yes" src="cid:image002.jpg@01D61C89.AC4998D0"></span></a><o:p class=""></o:p></div></td><td valign="bottom" style="padding: 3.75pt 3.75pt 15pt;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><a href="https://www.facebook.com/TheNeuroMNI/" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="color: blue; text-decoration: none;" class=""><img border="0" id="Picture_x0020_9" alt="Facebook" style="" class="" apple-inline="yes" src="cid:image003.jpg@01D61C89.AC4998D0"></span></a><o:p class=""></o:p></div></td><td valign="bottom" style="padding: 3.75pt 3.75pt 15pt;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><a href="https://www.instagram.com/theneuro_mni/" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="color: blue; text-decoration: none;" class=""><img border="0" id="Picture_x0020_8" alt="Instagram" style="" class="" apple-inline="yes" src="cid:image004.jpg@01D61C89.AC4998D0"></span></a><o:p class=""></o:p></div></td><td valign="bottom" style="padding: 3.75pt 3.75pt 15pt;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><a href="https://ca.linkedin.com/company/the-montreal-neurological-institute" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="color: blue; text-decoration: none;" class=""><img border="0" id="Picture_x0020_7" alt="LinkedIn" style="" class="" apple-inline="yes" src="cid:image005.jpg@01D61C89.AC4998D0"></span></a><o:p class=""></o:p></div></td><td valign="bottom" style="padding: 3.75pt 3.75pt 15pt;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><a href="https://www.youtube.com/user/MontrealNeuro" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="color: blue; text-decoration: none;" class=""><img border="0" id="Picture_x0020_6" alt="YouTube" style="" class="" apple-inline="yes" src="cid:image006.jpg@01D61C89.AC4998D0"></span></a><o:p class=""></o:p></div></td></tr></tbody></table></div></td></tr></tbody></table></td></tr><tr class=""><td style="background-color: rgb(71, 10, 105); padding: 0in; background-position: initial initial; background-repeat: initial initial;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="color: white;" class=""><img border="0" id="Picture_x0020_5" alt="Events Banner" style="" class="" apple-inline="yes" src="cid:image007.jpg@01D61C89.AC4998D0"></span><o:p class=""></o:p></div></td></tr><tr class=""><td style="background-color: white; padding: 0in; background-position: initial initial; background-repeat: initial initial;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="" class=""> </span><o:p class=""></o:p></div><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="100%" style="width: 765.0625px;"><tbody class=""><tr class=""><td style="padding: 15pt;" class=""><h3 style="margin-right: 0in; margin-left: 0in; font-size: 13.5pt; font-family: Calibri, sans-serif; font-weight: bold; line-height: 15pt;" class=""><span style="font-family: Arial, sans-serif;" class=""><img border="0" id="Picture_x0020_4" alt="cidimage008.png@01D6195C.D7756910" style="" class="" apple-inline="yes" src="cid:image008.png@01D61C89.AC4998D0"></span><o:p class=""></o:p></h3><h3 style="margin-right: 0in; margin-left: 0in; font-size: 13.5pt; font-family: Calibri, sans-serif; font-weight: bold; line-height: 15pt;" class=""><strong class=""><span style="font-family: Arial, sans-serif;" class="">Feindel Virtual Brain and Mind Seminar at The Neuro:</span></strong><span class="apple-converted-space"><span style="font-family: Arial, sans-serif;" class=""> </span></span><span style="font-family: Arial, sans-serif;" class=""><br class=""><strong class=""><span style="font-family: Arial, sans-serif;" class="">“Mapping neuropsychiatric mutation effects on functional brain connectivity to delineate dimensions contributing to autism and schizophrenia”</span></strong></span><o:p class=""></o:p></h3><h3 style="margin-right: 0in; margin-left: 0in; font-size: 13.5pt; font-family: Calibri, sans-serif; font-weight: bold; line-height: 15pt;" class=""><strong class=""><span style="font-family: Arial, sans-serif;" class="">Wednesday, April 29, 2020</span></strong><span style="font-family: Arial, sans-serif;" class=""><br class=""></span><span style="font-size: 12pt; font-family: Arial, sans-serif;" class="">4:00 - 5:00PM</span><span style="font-family: Arial, sans-serif;" class=""><br class=""><strong class=""><span style="font-family: Arial, sans-serif;" class="">Zoom</span></strong><span class="apple-converted-space"> </span>(<a href="https://www.mcgill.ca/neuro/channels/event/feindel-virtual-brain-and-mind-seminar-neuro-mapping-neuropsychiatric-mutation-effects-functional-321797" target="_blank" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="color: rgb(149, 79, 114);" class="">registration required</span></a>)<br class=""><br class="">Speaker: Clara Moreau</span><o:p class=""></o:p></h3><p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 7.5pt; line-height: 15pt;" class=""><strong class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Talk abstract</span></strong><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""><br class="">Copy number variants (CNVs) are among the most highly penetrant genetic risk factors for neuropsychiatric disorders. Because they confer risk for overlapping conditions, we hypothesized that they may converge on shared connectivity patterns. We performed connectome-wide analyses using resting-state fMRI data from 502 carriers of CNVs associated to different degrees with neuropsychiatric conditions, 756 individuals with idiopathic ASD, schizophrenia, attention deficit hyperactivity disorder, and 5,377 controls. We showed that the effect size of CNVs on connectivity was correlated with the known level of clinical risk conferred by mutations. We identified similarities between connectivity profiles of high-risk mutations and the connectivity architecture of individuals with schizophrenia and autism. Similarities were driven by the thalamus, and the posterior cingulate cortex, previously identified as major hubs altered across psychiatric conditions. Because these results raised questions about shared mechanisms across CNVs, we then posited that haploinsufficiency may reorganize connectivity along general dimensions irrespective of where deletions occur in the genome. Using a continuous score to quantify the severity of deletions (pLI), we identified a connectivity profile that appears to be present in deletions irrespective of genomic location. This profile was correlated with lower general intelligence and higher autism severity scores in 3 unselected and disease cohorts. Such general brain signatures open new avenues to understand polygenicity in psychiatric conditions and the pleiotropic effect of CNVs on cognition and risk for mental illnesses.</span><o:p class=""></o:p></p><p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 7.5pt; line-height: 15pt;" class=""><strong class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">The Feindel Virtual Brain and Mind (VBM) Seminar Series</span></strong><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""><br class="">Advancing the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.</span><o:p class=""></o:p></p><p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 7.5pt; line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.<br class="">If you, or someone you know, would be interested in presenting please contact us to secure a spot on the schedule.</span><o:p class=""></o:p></p><p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 7.5pt; line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Looking forward to reconnecting!</span><o:p class=""></o:p></p><p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 7.5pt; line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Nathan Spreng<br class="">Boris Bernhardt<br class="">Bratislav Misic<span class="apple-converted-space"> </span></span><o:p class=""></o:p></p><p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 7.5pt; line-height: 15pt;" class=""><strong class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">To register:</span></strong><span class="apple-converted-space"><b class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""> </span></b></span><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""><a href="https://www.eventbrite.ca/e/feindel-virtual-brain-and-mind-seminar-at-the-neuro-presents-clara-moreau-tickets-103427999932" style="color: rgb(149, 79, 114); text-decoration: underline;" class="">https://www.eventbrite.ca/e/feindel-virtual-brain-and-mind-seminar-at-the-neuro-presents-clara-moreau-tickets-103427999932</a></span><o:p class=""></o:p></p><p style="margin-right: 0in; margin-left: 0in; font-size: 12pt; font-family: "Times New Roman", serif; margin-bottom: 7.5pt; line-height: 15pt;" class=""><strong class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Contact :</span></strong><span class="apple-converted-space"><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""> </span></span><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Sasha Kelly, Events Coordinator,<span class="apple-converted-space"> </span><span style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><a href="mailto:neuroevents.mni@mcgill.ca" style="color: rgb(149, 79, 114); text-decoration: underline;" class="">neuroevents.mni@mcgill.ca</a></span></span></p></td></tr></tbody></table></td></tr><tr class=""><td style="background-color: white; padding: 0in; background-position: initial initial; background-repeat: initial initial;" class=""></td></tr></tbody></table></div></div></blockquote></div></div></div></div></body></html>