[BIC-announce] FW: Killam Lecture - Tuesday, March 13, 2007 @ 4:00 pm - Speaker: Dr. Paul De Koninck - spatial and Temporal Dynamics of CaM kinase II in Neurons

[Jennifer Chew, Ms.]

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From: MNISTAFF - Montreal Neurological Institute Staff [mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Felicia Callocchia, Ms.
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Subject: Killam Lecture - Tuesday, March 13, 2007 @ 4:00 pm - Speaker: Dr. Paul De Koninck



KILLAM LECTURE

 

 

Speaker:       Paul De Koninck, PhD

                   Centre de recherche Université Laval Robert-Giffard

 

Title:             Spatial and Temporal Dynamics of CaM kinase II in Neurons

 

Place:           de Grandpre Communication Centre

 

Date:            Tuesday, March 13, 2007

 

Time:            4:00 pm

 

________________________________

 

Dear colleagues,

 

The Killam speaker this week is Dr Paul De Koninck from the Centre de recherche Université Laval Robert-Giffard. Dr De Koninck investigates the

cellular and molecular mechanisms used by neurons to decode synaptic and electrical activities that propagate through neural circuits. He is

particularly interested in learning how these mechanisms contribute to synaptic remodeling and to the maintenance and modifications of brain

circuit connectivity. The model that he studies is the Ca2+-calmodulin-dependent pathway at excitatory synapses in the hippocampus. His

work is aimed primarily at learning how CaM kinase II decodes Ca2+ signals in neurons and modifies synaptic structures and function. Dr De Koninck uses

dissociated cultures or brain slices and in vitro approaches aimed at deciphering the structure / function of CaM kinase II as a decoder of Ca2+

oscillations.

 

Recent publications are listed below.

 

Please join us for what promises to be a very interesting seminar.

 

Ted

 

-------------------------

 

Edward A. Fon, MD, FRCP(C)

Killam Scholar

Montreal Neurological Institute

Assistant Professor

McGill University

Office: (514) 398-8398

Lab: (514) 398-5057

Fax: (514) 398-5214

ted.fon at mcgill.ca

http://www.mni.mcgill.ca/cfns.html#EdwardFon

 

 

Bayer K.-U., LeBel E., McDonald G.L., O'Leary H., Schulman H., De Koninck

P.(2006). Transition from reversible to persistent binding of CaMKII to

postsynaptic sites and NR2B. J. Neurosci. 26(4): 1164-74

 

Hudmon, A., LeBel, E., Roy, H., Schulman, H., Waxham, N. & De Koninck, P.

(2005). A mechanism for CaMKII clustering at synaptic and non-synaptic sites

based on self-association. J. Neurosci. 25: 6971-83

 

Dupont, G., Houart, G. & De Koninck, P. (2003) Sensitivity of CaM kinase II

to the frequency of Ca2+ oscillations: A simple model. Cell Calcium 34:

485-497.

 

Coull, J.A.M., Boudreau, D., Bachand, K., Prescott, S.A., Nault, F., Sík,

A., De Koninck, P. & De Koninck, Y. (2003) Transsynaptic shift in anion

gradient in spinal lamina I neurons as a novel mechanism of neuropathic

pain. Nature 424: 938-942.

 

Bayer, K.-U., De Koninck, P., Leonard, A.S., Hell, J.W. and Schulman, H.

(2001). Interaction with the NMDA Receptor locks CaMKII in an Active State.

Nature 411: 801-805.

 

De Koninck, P. & Schulman, H. (1998). Sensitivity of

Ca2+/calmodulin-dependent protein kinase II to the frequency of Ca2+

oscillations. Science 279: 227-230.