[MINC-users] Regional CBF differences

[John Absher]

Hi, Andrew,

Sorry, I didn't make this clear.  I don't need help with the registrations.
The 16 CBF PET scans, and the 4 MRIs for these 4 subjects are already in
Talairach space.

I seek an automated way to determine the quantitative CBF PET changes on a
region-by-region basis (rather than voxel by voxel).  I have 2 "baseline
blood pressure" scans and 2 "low-blood-pressure" scans per subject.  I want
to know how much blood pressure declined/changed in the thalamus, the
caudate, the cingulate gyrus, and all other "standard" brain regions, like
those defined by the Talairach atlas.

I'm hoping there's an automated way to calculate these regional CBF
differences.  I can use mincmath (Baseline1 - LowBP1, Baseline2-LowBP1,
etc.) to run all 4 possible subtractions for each of the 4 subjects, then
average these differnece images, again using mincmath.  However, I still
need some way to analyze the voxels in the difference images (one per
subject).  I'd like to do the whole brain, and print a table showing these
average differences, by region, by subject.

I hope that makes sense, now.  Thanks, for any help you can provide.

John


Date: Wed, 5 Sep 2007 16:19:47 +1000
From: "Andrew Janke" <a.janke at gmail.com>
Subject: Re: [MINC-users] Regional CBF differences
To: "MINC users mailing list" <minc-users at bic.mni.mcgill.ca>
Message-ID:
	<d747ed50709042319p3e0ee9f4n8eb2f9480b9c17ba at mail.gmail.com>
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Hi John,

I at a bit of a loss as to what your question is...  Do you want help
with the registrations (using either mritopet or mritotal) or with the
subtractions of the individuals (after registration to each other?)

?

a


On 8/31/07, John Absher <john at absherneurology.com> wrote:
> I have data from CBF PET for 4 subjects, 4 scans each, all normalized into
> sterotaxic space in mnc and analyze formats.  Two scans were at baseline
BP,
> and 2 scans were done under low BP conditions.  I would like to map, for
> each subject, the regional changes in absolute CBF using the HBM templates
> or another standard Talairach reference system.  I've already done the spm
> analysis, and know where the significant changes occurred.  However, due
to
> the small number of subjects, I needed to do the spm based on relative CBF
> changes, smoothed data, etc.


--
Andrew Janke   (a.janke at gmail.com || http://a.janke.googlepages.com/)
Canberra->Australia    +61 (402) 700 883