[BIC-announce] Fwd: Neuro Event: Feindel Seminar Series - Genomic Deletions and Duplications Show Effects on Cognitive Ability along the Hierarchical Gradient of the Cortical Organization - February 1, 4 p.m

[Boris Bernhardt]

Hi BIC & FYI, our lectures return tomorrow


Sent from my iPhone

Begin forwarded message:

From: NeuroEvents <events.neuro at mcgill.ca>
Date: January 31, 2023 at 1:44:07 PM EST
To: MNISTAFF at lists.mcgill.ca
Subject: Neuro Event: Feindel Seminar Series - Genomic Deletions and Duplications Show Effects on Cognitive Ability along the Hierarchical Gradient of the Cortical Organization - February 1, 4 p.m
Reply-To: NeuroEvents <events.neuro at mcgill.ca>



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[Text    Description automatically generated with low confidence]

Genomic Deletions and Duplications Show Effects on Cognitive Ability along the Hierarchical Gradient of the Cortical Organization



Kuldeep Kumar

Postdoctoral Fellow, CHU Sainte-Justine Research Centre, University of Montreal, Canada


February 1, 2023
4 p.m. EST
De Grandpré Communications Centre, The Neuro, 3801 rue University

Abstract: Cognitive ability is subserved by large-scale brain networks. Previous research has established a relationship between normative spatial patterns of gene expression across the cortex, and the neuroanatomical as well as the functional organization of the cortex. However, the relationship between variations in gene expression across the cortex and cognitive ability has not yet been systematically investigated. In this talk, I will focus on how copy number variants (CNVs), which are genomic deletions or duplications and fully encompass one or more genes, offer a unique opportunity to characterize the impact of inter-individual genetic variation on cognitive ability. Using one of the largest aggregated data with CNV calls and measures of cognitive ability, we map the effects of CNVs on cognitive ability across the human cortex. The deletion and duplication effect size maps show positive and negative correlations with the established hierarchical gradient of the cortical organization. Our findings suggest that mutations with opposing gene dosage alter cognitive ability when they affect genes with opposing spatial patterns of expression in the cortex, suggesting that there is an optimal balance of gene expression across large-scale brain networks.

The Feindel Seminar Series at The Neuro

Advances the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.

Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.

Registration required<https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.eventbrite.ca%2Fe%2Ffeindel-brain-and-mind-seminar-kuldeep-kumar-tickets-524730532147&data=05%7C01%7Cboris.bernhardt%40mcgill.ca%7C5695b571b6824ce2842008db03bb1fd9%7Ccd31967152e74a68afa9fcf8f89f09ea%7C0%7C0%7C638107874469986869%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Lg3a7Ns2aoM9uRiw8vfglAbanU0rvmkSuJYOPgv8290%3D&reserved=0>

Contact: Sasha Kelly<mailto:sasha.kelly at mcgill.ca>, Conference and Events Coordinator, The Neuro

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