[BIC-announce] Fwd: Neuro Event: Feindel Seminar - Bridging the Gap Between BigBrain and Functional MRI in Humans Using Biophysical Generative Models - April 11, 1:30 p.m

Wed Apr 5 17:02:31 EDT 2023

Hi BIC & FYI - post easter Feindel Lecture

Special time: Tuesday April 11, 1:30 p.m

Best wishes
Boris
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From: NeuroEvents <events.neuro at MCGILL.CA>
Date: Apr 5, 2023, 4:59 PM -0400
To: MNISTAFF at LISTS.MCGILL.CA <MNISTAFF at LISTS.MCGILL.CA>
Subject: Neuro Event: Feindel Seminar - Bridging the Gap Between BigBrain and Functional MRI in Humans Using Biophysical Generative Models - April 11, 1:30 p.m

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[Text Description automatically generated with low confidence]
Bridging the Gap Between BigBrain and Functional MRI in Humans Using Biophysical Generative Models*

Kamil Uludag<https://medbio.utoronto.ca/faculty/uludag>
Krembil Brain Institute, Canada

11 avril 2023
13 h 30
Centre de communications de Grandpré, Le Neuro, 3801, rue University

*La présentation sera en anglais

Bridging the Gap Between BigBrain and Functional MRI in Humans Using Biophysical Generative Models

Kamil Uludag<https://medbio.utoronto.ca/faculty/uludag>
Krembil Brain Institute, Canada

April 11, 2023
1:30 p.m.
De Grandpré Communications Centre, The Neuro, 3801, University Street

Abstract: In this talk, I will provide an overview of the physiological processes that contribute to the observed BOLD signal (i.e., the generative biophysical model), including their time course properties within the framework of the physiologically-informed dynamic causal modeling (P-DCM). Specifically, the physiological origin of the so-called BOLD signal “transients” will be discussed, including the initial overshoot, steady-state activation and the post-stimulus undershoot. I argue that incorrect physiological assumptions in the generative model of the BOLD signal can lead to incorrect inferences pertaining to both local neuronal activity and effective connectivity between brain regions. In addition, I introduce the recent laminar BOLD signal model, which extends P-DCM to cortical depths-resolved BOLD signals, allowing for laminar neuronal activity to be determined using high-resolution fMRI data. Finally, I outline a research program to leverage the BigBrain to develop brain-area specific microcircuit models, which can represent the neuronal component of the laminar fMRI signal model.

The Feindel Seminar Series at The Neuro
Advances the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.

Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.

Registration required<https://www.eventbrite.ca/e/feindel-brain-and-mind-seminar-kamil-uludag-tickets-601471606767>

Contact: Sasha Kelly<mailto:sasha.kelly at mcgill.ca>, Conference and Events Coordinator, The Neuro

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