[BIC-announce] MCIN lecture - special time: Wednesday, December 18th, 13:00

[Patrick Bermudez]

Please join us in the de Grandpré auditorium next Wednesday, the 18th
of December, for a lecture by Jacob Vogel entitled "Spatiotemporal
subtypes of Alzheimer's disease using tau-PET imaging".  Here is an
abstract of Jake's talk:

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Alzheimer's disease (AD) is characterized by pathological aggregation
of two different, aberrantly conformed proteins, beta-amyloid and tau.
Classic pathological studies based on extensive autopsy cohorts have
taught us that these proteins, particularly tau, spread through the
cerebral cortex in a specific and highly stereotyped manner. However,
rare subtypes of AD with divergent patterns of tau deposition have
been reported and some studies have also reported variation even in
typical AD.

Pathology studies suffer from limitations that make identifying
pathological subtypes challenging, including limited spatial sampling
and semi-quantitative measurement strategies. However, neuroimaging
subtyping studies have also been limited by non-specific measurements
and methodological challenges that I will discuss in detail.

I will report the application of a novel spatiotemporal subtyping
approach to a large (n=1764), multisite dataset of tau-PET images. I
will describe the phenotypic presentation of the subtypes identified,
how they conform with and diverge from previous literature, and how
these results fit with the current models of AD pathological
progression.
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