[BIC-announce] CREATE-MIA Seminars: Friday, April 24

Wed Apr 22 12:00:37 EDT 2015

Dear all,

There will be three CREATE-MIA Seminars this Friday, April 24.  All are welcome!

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 "Investigating the role of age-related vascular changes on brain oxygenation”

Speaker: Prof. Frédéric Lesage, Department of Electrical Engineering, École Polytechnique Montréal
Location: Macdonald Engineering Building, MD267
Time: 11am-noon 

Abstract:
Using various optical techniques: intrinsic imaging, optical coherence tomography and two photon microscopy, we investigate changes in the brain functional response with age and its relation to microvasculature. We identify brain vessel pulsatility as a contributor to flow mediated dilation and investigate the consequences of these changes on brain oxygenation. Finally, a model of the BOLD response is built from first principles to translate these results to the macroscopic world.

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"Distribution of Synaptic Vesicles”

Speaker: Prof. Jon Sporring, Department of Computer Science, University of Copenhagen
Location: McConnell Engineering Building, MC437
Time: 1:15pm - 2:15pm 

Abstract:
Vesicles store neurotransmitters that are released at the synapse for chemical communication between nerve cells. We have analyzed the statistical nature of synaptic vesicle’s location in serial section transmission electron microscope images of rat's brains during stress and sham-stress treatment. Serial section transmission electron microscope imaging poses a particular challenge, since the images have to be reassembled after sectioning in order to study positions in 3 dimensions, and since uncertainty on location is heavily skewed due to uncertainty about the section thickness and due the transmission process, which results in a projection. We propose methods for estimating the thickness of sections by image statistics alone and for fitting parametrized densities in the case of projection.

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"Geometric Paradigms for MRI Analysis With Applications to Cardioimaging and Neuroimaging”

Speaker: Prof. Luc Florack, Department of Mathematics and Computer Science, Eindhoven University of Technology
Location: McConnell Engineering Building, MC12
Time: 2:30pm - 3:30pm

Abstract: 
Magnetic Resonance Imaging (MRI) is a non-invasive and highly versatile imaging modality, with unprecedented capabilities for disclosing in-vivo anatomical and functional information. Imaging protocols as well as image analysis paradigms are traditionally set up so as to convey this information to the radiologist in a format geared towards visual interpretation, supported by software platforms for interactive “data visualization” and add-ons for quantification of visual structures.

The advent of increasingly sophisticated acquisition schemes, producing complex highcodimensional images, prohibits a direct visual approach, calling for a radically new paradigm, with a more compelling role for theory to address notorious inverse problems. Examples of these are “diffusion weighted MRI” and spatial modulation of magnetization, or “tagging MRI”. The data produced in these cases are “non-visual images” that admitquantification and visually exploration (“visual analytics”) only by virtue of an priori axiomatic framework for their interpretation. The necessary axiomatics emerges from the interplay of the physical sciences (mathematics, physics), and often leads to a revaluation of established theories originally developed in a different context.

Image researchers worldwide are starting to embrace the new paradigm, trying to “see what one can understand” rather than trying to “understand what one can see”. Physics, a rigorous and universal description language, are indispensable in this endeavor.

In this presentation I will illustrate the above rationale in the context of a differential geometric framework for the analysis of diffusion and tagging MRI data with “off-the-shelf” physics and mathematics from early twentieth century.

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Full details are available on the CREATE-MIA website (http://cim.mcgill.ca/create-mia).

Best,
Krys

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Krys (Christine) Dudek
Program Administrator, NSERC CREATE Program for Medical Image Analysis
Centre for Intelligent Machines
3480 University Street
McConnell Engineering Building, Room 410
Montreal, Quebec, Canada
H3A 2A7

kdudek at cim.mcgill.ca
514.398.6319

www.cim.mcgill.ca/create-mia

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