[BIC-announce] Seminar in Biomedical Engineering - Wednesday Feb 19th - 1h pm - Room 333

[Christophe Grova]

Dear all, 

We will have our next  Biomedical Engineering seminar today

Wednesday  ­ Feb 19th,  at 1 pm

Location: Room  333 Lyman Duff Building (Biomedical Engineering Dpt, 3775
University Street).

Speaker:  Dr . Roberto Carlos Sotero Diaz, PhD, postdoctoral fellow under
the supervision of Dr. A. Shmuel, Montreal Neurological Institute, McGill
University, Montreal, Canada

Title: 
"Modeling and analysis of neurovascular processes at the meso-scale"


Abstract:
Resting-state functional connectivity involves cross-frequency coupling
(CFC) of local-field potentials (LFP); however, the underlying
laminar-specific mechanisms remain poorly understood.  I will first propose
a mathematical model that captures the interactions of laminar-specific
excitatory and inhibitory neuronal populations, and estimate this model from
evoked LFP recorded in rat area S1. I will then quantify intra- and
inter-laminar spontaneous phase-phase, amplitude-amplitude (AAC) and
phase-amplitude (PAC) couplings, and their influence on optically measured
hemodynamic signals. Spontaneous LFP in layers 2/3-5a and 6 formed 2
clusters whose interaction can be captured by a model of two weakly coupled
oscillators. PAC was especially high between the theta and fast-gamma bands.
Intra- and inter-laminar PAC and AAC involving layers 2/3-5a were higher
than those involving layer 6. Of the three CFC modalities, PAC in layers
2/3-5a provided the most consistent link between low and high-frequency
oscillations. PAC showed the strongest influence on hemodynamic signals. Our
findings emphasize the strong influence of anatomical connectivity on
functional connectivity between cortical layers. They further indicate that
intra- and inter-laminar PAC may play a role in neurophysiology-based
resting-state functional-connectivity and in the mechanisms underlying its
functional-MRI counterpart.


A list of upcoming seminars can be found at :
http://www.mcgill.ca/bme/news/seminars

See you there 

 
Christophe Grova 

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Christophe Grova, PhD
Assistant Professor
Biomedical Engineering Dpt
Neurology and Neurosurgery Dpt
 
Multimodal Functional Imaging Lab (Multi FunkIm)
Montreal Neurological Institute
Centre de Recherches en Mathématiques
 
Biomedical Engineering Department - Room 304
McGill University
3775 University Street, Montreal, Quebec, Canada,
H3A 2B4 
email : christophe.grova at mcgill.ca <mailto:christophe.grova at mcgill.ca>
tel : (514) 398 2516
fax : (514) 398 7461
 
Web:
http://www.bic.mni.mcgill.ca/ResearchLabsMFIL/PeopleChristophe
http://www.bmed.mcgill.ca/
MultiFunkIm Lab:
http://www.bic.mni.mcgill.ca/ResearchLabsMFIL/HomePage
 
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