[BIC-announce] [TOMORROW] Special BIC Lecture (Wed-May-08, 4:00 pm, de Grandpré Communications Centre; Dr. Jean-Baptiste Poline -- "Statistical Detection and Reproducibility Issues in Brain Imaging Genetics Methods")

Tue May 7 15:58:14 EDT 2013

*Special BIC Lecture*

The BIC Lecture
Series<http://www.bic.mni.mcgill.ca/Seminars/BICLectureSeries>
features
informal lectures on brain imaging presented at the McConnell Brain Imaging
Centre <http://www.bic.mni.mcgill.ca/Main/HomePage> (*BIC*) by experts in
the field.  These lectures are open to all.

Please join us *tomorrow* for a Special BIC Lecture, which will be held in The
Neuro's de Grandpré Communications
Centre<http://neuromedia.mcgill.ca/mnibooking/facdirections/dgccdir.htm>
 (3801
University Street, Montreal, QC, H3A 2B4)* *at a special time:
*Wednesday, May the 8th, starting at 4:00 pm**.*
*
*
*At that time, Dr.
<http://scholar.google.com/citations?sortby=pubdate&hl=en&user=BU7Zdi4AAAAJ&view_op=list_works>Jean-Baptiste
Poline<http://scholar.google.com/citations?sortby=pubdate&hl=en&user=BU7Zdi4AAAAJ&view_op=list_works>
 will be discussing statistical detection and reproducibility issues in
brain imaging genetics methods (see below for more details). *

Cheers!
Aki

-------------------------------------------
*Statistical detection and reproducibility issues in brain imaging genetics
methods** [Dr. <http://scholar.google.com/citations?sortby=pubdate&hl=en&user=BU7Zdi4AAAAJ&view_op=list_works>Jean-Baptiste
Poline<http://scholar.google.com/citations?sortby=pubdate&hl=en&user=BU7Zdi4AAAAJ&view_op=list_works>
]*
*In the first part of this talk, I will summarize some of the key aspects
of the current imaging genetics data analysis field. I will address
the issue of multiple testing and describe some multivariate methods that
are likely to help increase the sensitivity of brain wide - genome
wide analysis significance. I will use the example of brain imaging
traits heritability to illustrate some of the issues, and also to describe
new approaches for dealing with the data high dimensionality.  **In the
second part, I will address the related issue of reproducibility of imaging
genetics studies. This issue of reproducibility is receiving more and more
attention in the field of brain imaging, and with fMRI in particular
some researchers estimate that only 20 to 50% of the published fMRI results
are likely to be reproducible. The factors for this are numerous (see for
instance Ioannidis et al., 2005). I will argue that Imaging Genetics
studies are likely to be plagued by the very issues that are impacting fMRI
reproducibility. I will then discuss the need for replication and for
neuroinformatics standards and their relation to the publication framework.*
*

Jean-Baptiste Poline obtained an Engineering degree in 1989, and a
master degree in Biomathematics in 1990 (University Paris Diderot). During
his PhD, he worked on the detection of brain activation in Positron
Emission Tomography images in Orsay. From 1994 to 1997, he was a
post-doctoral fellow  in London with R. Frakowiack and K. Friston. He
returned to Orsay and then move to Neurospin in 2006 to work on fMRI data
analyses and on imaging genetics.  He is currently at the University of
California at Berkeley Brain Imaging Center and his current interests are
in biostatistics and neuroinformatics.
*

-------------------------------------------
*BIC Lecture Series: Winter-2013 Program
**BIC Lectures are typically held on Mondays at 1:00 pm in the de Grandpré
Communications Centre of The Neuro.
**For more information and links to the presentations as they become
available, please visit the BIC Lecture
website<http://www.bic.mni.mcgill.ca/Seminars/BICLectureSeries>
.*

01) Feb-11:  *Nature versus Nurture: Contributions Towards Healthy
Cognition from Childhood to Senescence in Mice and Humans* -- Dr. Veronique
Bohbot <http://www.douglas.qc.ca/researcher/veronique-bohbot?locale=en>
02) Feb-18:  *Functional Brain Plasticity Induced by Musical Training* -- Dr.
Sibylle Herholz<http://www.uni-muenster.de/OCCMuenster/phd-students/sibylle-herholz.html>
03) Feb-25:  *Optimization of the PET Detector Blocks for a Small-Animal
PET Scanning Insert for Simultaneous PET/MRI* -- Dr. Chris
Thompson<http://www.mni.mcgill.ca/neuro_team/mbic/christopher_thompson/>

04) Mar-01:  *Lactate Links Brain Energy Metabolism to Cerebral Blood Flow*
 -- Dr. Albert Gjedde<http://www.bric.ku.dk/staff_dynamic/staff/description/?id=52543&f=2>
05) Mar-04:  *Multi-Manifold Diffeomorphic Metric Mapping for Cortical
Registration: Applications in Structural and Functional Studies of the Brain
* -- Dr.  <http://koskilab.mcgill.ca/people.html#JZ>Jidan
Zhong<http://koskilab.mcgill.ca/people.html#JZ>
06) Mar-11:  *Auditory-Motor Control of Singing* -- Dr.
<https://files.nyu.edu/jmz2039/public/>Jean
Mary Zarate <https://files.nyu.edu/jmz2039/public/>
07) Mar-18:  *The Brain on TED* -- Mr. Benjamin
Elgie<http://www.mcgill.ca/graccolab/people#BENJAMIN>
08) Mar-25:  *Glimpses Into Consciousness From the Ways We Lose It* -- Dr.
George Kostopoulos<http://physiology.med.upatras.gr/NU/index.php?option=com_content&view=article&id=9&catid=6&Itemid=16>

---) Apr-01:  *No Lecture: Easter Monday*
09) Apr-08:  *The Brain on TED, 2* -- Mr. Benjamin
Elgie<http://www.mcgill.ca/graccolab/people#BENJAMIN>
---) Apr-15:  *No Lecture: Neuropsychology Day*
---) Apr-22:  *No Lecture: ISMRM Conference*
---) Apr-29:  *No Lecture*

 10) May-06:  *PET Imaging: Recent Research Highlights in Reconstruction
and Analysis* -- Dr. Andrew
Reader<http://www.mni.mcgill.ca/neuro_team/mbic/andrew_reader/>
11) Wed-May-08_4pm:  *Statistical Detection and Reproducibility Issues in
Brain Imaging Genetics Methods* -- Dr.
<http://scholar.google.com/citations?sortby=pubdate&hl=en&user=BU7Zdi4AAAAJ&view_op=list_works>Jean-Baptiste
Poline<http://scholar.google.com/citations?sortby=pubdate&hl=en&user=BU7Zdi4AAAAJ&view_op=list_works>
12) May-13:  *Impaired Structural Correlates of Memory in a Mouse Model of
Alzheimer’s Disease* -- Dr. Aman Badhwar
---) May-20:  *No Lecture: Victoria Day*
13) May-27:  *Brain Fuel Metabolism in Aging and Mild Alzheimer’s Disease:
Comparison of 18F-FDG with a Novel PET Ketone tracer -- 11C-Acetoacetate*
 -- Dr. Stephen
Cunnane<http://www.usherbrooke.ca/dep-medecine/recherche/professeurs-ayant-des-activites-de-recherche/endocrinologie/pr-stephen-cunnane/>

-- 
Zografos Caramanos, M.A.

Research Assistant, Magnetic Resonance Spectroscopy Unit
Ph.D. Student, Integrated Program in Neuroscience

McConnell Brain Imaging Centre,
Montreal Neurological Institute, McGill University
3801 University Street, Montreal, Quebec, Canada, H3A 2B4
(phone) 514-299-8160;  (fax) 514-398-2975
(e-mail) zografos.caramanos at mcgill.ca<https://mail.google.com/mail/?view=cm&fs=1&tf=1&to=zografos.caramanos@mcgill.ca>
(web)  Google-scholar<http://scholar.google.ca/citations?sortby=pubdate&hl=en&user=BcVBulQAAAAJ&view_op=list_works>
   www.zcaramanos.com
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