[BIC-announce] Seminar in Biomedical Engineering - Wednesday Feb 27th - 1 pm - Room 333

[Christophe Grova]

Dear all,

Our next Biomedical Engineering Dpt seminar  is this coming wednesday

Wednesday - February 27th,  at 1 pm

Location: Room  333 Lyman Duff Building (Biomedical Engineering Dpt, 3775  University Street).

Speaker: Cloe Rainville, Master student under the supervision of Dr. M. Tabrizian, BME, McGill University

Since Cloe is a Master student registered to the course BMDE500 who is giving this seminar as part of McGill conditions to obtain his M.Sc., special attendance from our department (staff and students) is really expected, in order to give Cloe feedback on his research studies.

Title : Investigation of the integrity of layer-by-layer coated red blood cells in a microfluidic device

Abstract:
My masters project aims at investigating the integrity of coated red blood cells (RBC) for the purpose of immunocamouflage. The principle of immunocamouflage of RBCs through the layer-by-layer (LbL) self-assembly technique has previously been shown by Sania Mansouri, a PhD student from Dr. Tabrizian’s lab.  It has been demonstrated that when layers of modified polymers are used to coat the red blood cell, immunocamouflage is successful in that the cells remain functional, they are viable and their antigens are undetected when placed in an appropriate antibody solution.  My aim is to design and develop a microfluidic device that will simulate the passage of red blood cells through human capillaries to then investigate whether their immunocamouflage properties remain intact.  The experimental approach involves the coating of red blood cells using the LbL self-assembly technique. The coated RBCs are then pushed through the designed microfluidic system with channels of varying widths mimicking the diameters of small blood vessels in the body: 0.002mm, 0.004 mm, 0.006 mm, 0.008 mm, 0.01 mm and a control of 0.1 mm.  The cells are then be investigated to detect any morphological changes or defects that may have occurred during passage through the smaller diameter vessels and the results are compared with a control where bare (uncoated) RBCs are subjected to the same conditions as the coated RBCs.  Different techniques to evaluate the red blood cell’s integrity will be discussed in the presentation as well as my progress to date.


A list of upcoming seminars can be found at : http://www.mcgill.ca/bme/news/seminars

See you there


Christophe Grova


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Christophe Grova, PhD
Assistant Professor
Biomedical Engineering Dpt
Neurology and Neurosurgery Dpt

Montreal Neurological Institute
Centre de Recherches Mathématiques

Biomedical Engineering Department - Room 304
McGill University
3775 University Street, Montreal, Quebec, Canada, H3A 2B4
email : christophe.grova at mcgill.ca
tel : (514) 398 2516
fax : (514) 398 7461

web:
http://www.mni.mcgill.ca/research/gotman/members/christophe.html
http://www.bmed.mcgill.ca/
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