[BIC-announce] FW: Killam Lecture - Tuesday, February 5, 2012 - Dr Gerhard Mulhaup - The Role of Secretases in the amyloid Puzzle

[Jennifer Chew, Ms.]

From: MNISTAFF - Montreal Neurological Institute Staff [mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Enza Ferracane, Ms.
Sent: Monday, February 04, 2013 2:03 PM
To: MNISTAFF at LISTS.MCGILL.CA
Subject: Killam Lecture - Tuesday, February 5, 2012 - Dr Gerhard Mulhaup

Killam Lecture

Speaker:  Dr. Gerhard Multhaup, PhD
Department of Pharmacology & Therapeutics
McGill University

Title:  The Role of Secretases in the Amyloid Puzzle

Date:  Tuesday, February 5th, 2012

Time:  4pm

Place:  de Grandpré Communications Centre
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Dear Colleagues,

The Killam speaker this week will be Dr Gerhard Multhaup. Gerd recently moved to McGill to assume the position of Professor and Chair, Department of Pharmacology and Therapeutics. Previously, he was Head of the Department of Biochemistry, Free University of Berlin where he was Coordinator of the DFG Priority Program "Cellular mechanisms of Alzheimer‘s disease". Dr Multhaup has published close to 200 papers. His interests are aimed at understanding the molecular, cellular and systemic mechanisms of degenerative nervous system disorders, in particular Alzheimer’s and other dementias. His research is focused on unraveling the mechanisms involved in Aβ generation by structural and functional analyses and the molecular events of amyloid aggregation, gain of toxicity and how they cause neuronal dysfunction. The overall aim is to identify novel targets to develop pharmacological treatment in AD. I hope you will join us for his seminar entitled: "The Role of Secretases in the Amyloid Puzzle"

Below are selected recent publications:
Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers.<http://www.ncbi.nlm.nih.gov/pubmed/22514144>
Kaden D, Harmeier A, Weise C, Munter LM, Althoff V, Rost BR, Hildebrand PW, Schmitz D, Schaefer M, Lurz R, Skodda S, Yamamoto R, Arlt S, Finckh U, Multhaup G.
EMBO Mol Med. 2012 Jul;4(7):647-59

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.<http://www.ncbi.nlm.nih.gov/pubmed/21441896>
Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J.
EMBO J. 2011 May 18;30(10):2057-70

The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators.<http://www.ncbi.nlm.nih.gov/pubmed/21186781>
Botev A, Munter LM, Wenzel R, Richter L, Althoff V, Ismer J, Gerling U, Weise C, Koksch B, Hildebrand PW, Bittl R, Multhaup G.
Biochemistry. 2011 Feb 8;50(5):828-35

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.<http://www.ncbi.nlm.nih.gov/pubmed/20679249>
Richter L, Munter LM, Ness J, Hildebrand PW, Dasari M, Unterreitmeier S, Bulic B, Beyermann M, Gust R, Reif B, Weggen S, Langosch D, Multhaup G.
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602

Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.<http://www.ncbi.nlm.nih.gov/pubmed/20452985>
Munter LM, Botev A, Richter L, Hildebrand PW, Althoff V, Weise C, Kaden D, Multhaup G.
J Biol Chem. 2010 Jul 9;285(28):21636-43

Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity.<http://www.ncbi.nlm.nih.gov/pubmed/19515926>
Harmeier A, Wozny C, Rost BR, Munter LM, Hua H, Georgiev O, Beyermann M, Hildebrand PW, Weise C, Schaffner W, Schmitz D, Multhaup G.
J Neurosci. 2009 Jun 10;29(23):7582-90

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.<http://www.ncbi.nlm.nih.gov/pubmed/17332749>
Munter LM, Voigt P, Harmeier A, Kaden D, Gottschalk KE, Weise C, Pipkorn R, Schaefer M, Langosch D, Multhaup G.
EMBO J. 2007 Mar 21;26(6):1702-12

Best wishes,
Ted

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