[BIC-announce] FW: Killam Lecture - Tuesday, April 23, 2013 - Dr. Seung-Jae Lee - Extracellular Alpha-Synuclein: Unusual Suspect of Lewy Body Diseases

[Jennifer Chew, Ms.]

PLEASE DISCARD IF THIS IS A DUPLICATE.  Jennifer 

From: MNISTAFF - Montreal Neurological Institute Staff [mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Angela Broccoli, Mrs.
Sent: Monday, April 22, 2013 11:34 AM
To: MNISTAFF at LISTS.MCGILL.CA
Subject: Killam Lecture - Tuesday, April 23, 2013 - Dr. Seung-Jae Lee

Dear Colleagues:

The Killam speaker this week will be Dr. Seung-Jae Lee. Seung-Jae is at Konkuk University, Seoul, Korea. His laboratory uses molecular, cellular and transgenic approaches to address mechanisms of neurodegeneration in Parkinson's disease (PD). Seung-Jae has focused on understanding the role of alpha-synuclein, a key protein in PD. In particular, Seung-Jae was the first to show that, despite its presumed cytosolic localization, alpha-synuclein is secreted by neurons. This idea has gained enormous momentum recently with work showing that alpha-synuclein may propagate from neuron-to neuron in the brain, in  a manner akin to prion disease. I hope you will join us for his seminar entitled: "Extracellular Alpha-Synuclein: Unusual Suspect of Lewy Body Diseases" 

Best wishes,
Ted Fon

Below are selected recent publications:

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia.
Kim C, Ho DH, Suk JE, You S, Michael S, Kang J, Joong Lee S, Masliah E, Hwang D, Lee HJ, Lee SJ.
Nat Commun. 2013;4:1562
 
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.
Bae EJ, Lee HJ, Rockenstein E, Ho DH, Park EB, Yang NY, Desplats P, Masliah E, Lee SJ.
J Neurosci. 2012 Sep 26;32(39):13454-69.

Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein.
Bae EJ, Ho DH, Park E, Jung JW, Cho K, Hong JH, Lee HJ, Kim KP, Lee SJ.
Antioxid Redox Signal. 2013 Mar 1;18(7):770-83
 
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.
Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S, Hwang D, Masliah E, Lee SJ.
J Biol Chem. 2010 Mar 19;285(12):9262-72
 
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.
Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ.
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13010-5.

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.
Lee HJ, Patel S, Lee SJ.
J Neurosci. 2005 Jun 22;25(25):6016-24

Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.
Lee HJ, Khoshaghideh F, Patel S, Lee SJ.
J Neurosci. 2004 Feb 25;24(8):1888-96