[BIC-announce] Seminar in Biomedical Engineering - Wednesday October 31st - 1 pm- Room 333

[Christophe Grova]

Dear all,

Our  next Biomedical Engineering Dpt seminar is this coming wednesday

Wednesday - October 31st,  at 1 pm

Location: Room  333 Lyman Duff Building (Biomedical Engineering Dpt, 3775  University Street).

Speaker: Hossein Khadivi Heris, PhD candidate under the supervision of Pr. L. Mongeau,
Biomechanics Laboratory, Department of Mechanical Engineering, McGill University

Title : Mechanical and structural characterization of vocal fold tissue towards scarring diagnosis and treatment

Abstract:
The flow-induced vibrations of the vocal folds are the primary sound source in human voice production. Vocal fold scarring is a serious pathology that may result from the surgical removal of benign or malignant vocal fold lesions, from voice overuse, or from intubation over an extended period of time. Scarring causes excessive stiffness in the tissue, thereby hampering normal phonation. The diagnosis, the evaluation and the treatment of vocal fold scarring is therefore of interest and the subject of this presentation. Atomic force microscopy-based indention and nonlinear laser scanning microscopy (NLSM) were used to study the structure and the stiffness of chronic scarring in rat animal models. NLSM was hypothesized to capture fibrosis; this method could potentially be developed further for vocal fold scar diagnosis in vivo. Results from NLSM of normal and scarred vocal fold tissue will be shown and discussed.  There is presently no ideal technique to treat scarring in the vocal fold lamina propria (LP). A novel advanced injectable biomaterial to treat LP scarring through tissue engineering methods was investigated. A hydrogel network was fabricated that combines injectability (a feature of the matrix) with structural integrity and functional microparticles (a cell-specific feature). The pH responsiveness of the synthesized hydrogel was found to make it suitable for the smart delivery of growth factors and therapeutics. The hierarchical network of Hyaluronic acid/Gelatin with scaffolding and drug delivery characteristic was tested in rat animal models. The potential of HA-gelatin treatments to promote tissue remodeling will be discussed.


A list of upcoming seminars can be found at : http://www.mcgill.ca/bme/news/seminars

See you there

Christophe Grova

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Christophe Grova, PhD
Assistant Professor
Biomedical Engineering Dpt
Neurology and Neurosurgery Dpt
Montreal Neurological Institute
Centre de Recherches en Mathématiques
Biomedical Engineering Department - Room 304
McGill University
3775 University Street, Montreal, Quebec, Canada, H3A 2B4
email : christophe.grova at mcgill.ca<mailto:christophe.grova at mcgill.ca>
tel : (514) 398 2516
fax : (514) 398 7461

web:
http://www.mni.mcgill.ca/research/gotman/members/christophe.html
http://www.bmed.mcgill.ca/
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