[BIC-announce] Special Seminar in Biomedical Engineering - candidate for Associate Membership in BME - Friday October 26th - 1 pm - Room 333

[Christophe Grova]

Dear all,

We will have a special seminar in Biomedical Engineering TODAY at 1h pm .
Pr. Near is candidate for associate membership in our department, so participation of staff and students is expected.

Friday - October 26th,  at 1 pm

Location: Room  333 Lyman Duff Building (Biomedical Engineering Dpt, 3775  University Street).

Speaker: Pr. Jamie Near PhD,  Assist. Professor in Psychiatry at the Douglas Institute of McGill University

Title : In-Vivo Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid at 3T

Abstract:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the adult human brain and its role is predominantly in the regulation of neuronal activity.  Unambiguous magnetic resonance spectroscopy (MRS) detection of GABA is challenging due to the presence of overlapping metabolite and macromolecule(MM) resonances which obscure the relatively low-intensity GABA signal. Therefore, quantitative measurements of GABA require the use of advanced MRS acquisition techniques.  In this presentation, I will introduce and discuss two localised J-difference editing techniques for GABA detection: MEGA-PRESS and MEGA-SPECIAL.  The former is well established and probably the most commonly used GABA detection method, while the latter is a recently developed technique which enables the effective removal of MM contamination.  I will then discuss the possibility of using ultrashort echo-time (TE) MRS as an alternative to spectral editing for GABA detection at 3T.  The use of ultrashort-TE MRS provides a number of important advantages over spectral editing approaches, the most notable being the possibility of detecting a large number of metabolites (including GABA) simultaneously in a single acquisition.  The accuracy and reproducibility of ultrashort-TE GABA measurements will be demonstrated using the results of both Monte-Carlo simulations and reproducibility experiments.  Finally, I will present an overview of the results of several recent studies which have demonstrated that GABA concentrations in the human brain are strongly linked with functional magnetic resonance imaging contrast in the human brain, as well as behaviour


A list of upcoming seminars can be found at : http://www.mcgill.ca/bme/news/seminars

See you there

Christophe Grova

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Christophe Grova, PhD
Assistant Professor
Biomedical Engineering Dpt
Neurology and Neurosurgery Dpt
Montreal Neurological Institute
Centre de Recherches en Mathématiques
Biomedical Engineering Department - Room 304
McGill University
3775 University Street, Montreal, Quebec, Canada, H3A 2B4
email : christophe.grova at mcgill.ca<mailto:christophe.grova at mcgill.ca>
tel : (514) 398 2516
fax : (514) 398 7461

web:
http://www.mni.mcgill.ca/research/gotman/members/christophe.html
http://www.bmed.mcgill.ca/
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