[BIC-announce] Seminar in Biomedical Engineering - Wednesday November 28th - 1 pm - Room 333

[Christophe Grova]

Dear all,

Our next Biomedical Engineering Dpt seminar is today

Wednesday - November 28th,  at 1 pm

Location: Room  333 Lyman Duff Building (Biomedical Engineering Dpt, 3775  University Street).

Speaker: Dr Frederic Leblond, PhD, Professeur adjoint, Ecole Polytechnique de Montréal, Physics Engineering Dpt

Title : Quantitative and depth-resolved fluorescence imaging of brain tumors can improve margins detection during surgery

Abstract:
  Techniques that aid visualization of pathophysiological processes are required to guide interventional procedures. Real-time fluorescence imaging has been shown as a promising adjunct for surgical guidance, but current intraoperative techniques are limited in their ability to probe diseased tissue, and fully exploit the targeting potential of fluorescent agents. The use of spectrally resolved in vivo fluorescence imaging offers the potential to significantly improve detection of disease and delineation of normal tissues because it can provide sensitive quantitative and depth-resolved information relating to specific fluorescent molecular markers by exploiting the signature associated with their emission spectrum. I will present a wide-field fluorescence imaging system that integrates with modern surgical microscopes, and enables spectrally resolved quantitative and depth-resolved measurements of fluorophore concentrations across a surgical field of view compatible with any type of brain surgery. I will present tissue-simulating phantom, pre-clinical and first in-human clinical results in tumor resection using the metabolic marker Protoporphyrin IX following systemic injection of 5-aminolevulinic acid. The technique is shown to provide quantitative values of PpIX concentration in tissue as well as to improve detection limits and contrast by 1-2 orders of magnitude compared to state-of-the-art intraoperative fluorescence imaging methods.

A list of upcoming seminars can be found at : http://www.mcgill.ca/bme/news/seminars

See you there


Christophe Grova


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Christophe Grova, PhD
Assistant Professor
Biomedical Engineering Dpt
Neurology and Neurosurgery Dpt

Montreal Neurological Institute
Centre de Recherches Mathématiques

Biomedical Engineering Department - Room 304
McGill University
3775 University Street, Montreal, Quebec, Canada, H3A 2B4
email : christophe.grova at mcgill.ca
tel : (514) 398 2516
fax : (514) 398 7461

web:
http://www.mni.mcgill.ca/research/gotman/members/christophe.html
http://www.bmed.mcgill.ca/
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