[BIC-announce] Seminar in Biomedical Engineering - Wednesday November 21st - 1 pm - Room 333

[Christophe Grova]

Dear all,

Our next Biomedical Engineering Dpt seminar is this coming wednesday

Wednesday - November 21st,  at 1 pm

Location: Room  333 Lyman Duff Building (Biomedical Engineering Dpt, 3775  University Street).

Speaker: Dr Gijs IJpma, PhD, post-doc fellow under the joint supervision of Dr Anne-Marie Lauzon and Dr James G. Martin, Department of Medicine,. Meakins-Christie Laboratories. McGill University

Title : Airway Smooth Muscle Mechanics

Abstract:


Studies have shown that breathing dynamics have a substantial effect on airway constriction in healthy and diseased subjects, yet little is known about the dynamic response of the main instigator of airway constriction, Airway Smooth Muscle. In this talk I’ll discuss the relative contributions of each of the processes that govern airway smooth muscle mechanical behaviour. I’ll discuss several models developed to further the understanding of ASM dynamics, particularly the roles and interactions of the three dominant processes in the muscle: contractile dynamics, length adaptation and passive dynamics. Contractile models describe the contractile process and the influence of external excitation on contractile behaviour. However these models are limited in their ability to predict ASM dynamics as they ignore the unique ability of smooth muscle to generate the same maximum force over a wide length range (length adaptation). Furthermore, recent studies have shown that while passive static forces are small in relaxed ASM, the assumption that they play no role in contracted ASM may not be correct. I will show evidence that contractile dynamics are largely determined by the dynamics of non-contractile proteins and processes rather than the cross-bridge cycling assumed in most models.

A list of upcoming seminars can be found at : http://www.mcgill.ca/bme/news/seminars



See you there



Christophe Grova



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Christophe Grova, PhD
Assistant Professor
Biomedical Engineering Dpt
Neurology and Neurosurgery Dpt

Montreal Neurological Institute
Centre de Recherches en Mathématiques

Biomedical Engineering Department - Room 304
McGill University
3775 University Street, Montreal, Quebec, Canada, H3A 2B4
email : christophe.grova at mcgill.ca
tel : (514) 398 2516
fax : (514) 398 7461

web:
http://www.mni.mcgill.ca/research/gotman/members/christophe.html
http://www.bmed.mcgill.ca/
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