[BIC-announce] Seminar in Biomedical Engineering - Wednesday March 7th at 13h

[Christophe Grova]

Dear all,

Our next Biomedical Engineering Dpt seminar is this coming wednesday 

Wednesday - March 7th,  at 13h

Location: Room  333 Lyman Duff Building (Biomedical Engineering Dpt, 3775 University Street).

Speaker: Rebecca Thompson, Master student under the supervision of Dr. D Bobyn 

Since Rebecca is a Master student who is giving this seminar as part of the course BMDE500, special attendance from our department (staff and students) is really expected, in order to give Rebecca feedback on her research studies.  

Title: Bisphosphonates and Bone Formation Around Porous Titanium Orthopedic Implants

Abstract:
Previous animal studies have shown the ability of locally delivered zoledronic acid (ZA) for enhancing bone formation around fully porous tantalum implants. Less potent bisphosphonates such as alendronic acid (AA) have a longer clinically successful history and may be similarly applicable to this concept, the rationale of which is to improve the reliability and longevity of biologic implant fixation in arthroplasty surgery. The purpose of this study was to determine whether locally delivered alendronic acid increased net bone formation around and within porous structured titanium implants.

Implants were manufactured for use in a canine femoral e intramedullary model, and were superficially coated with a layer of calcium phosphate and alendronic acid. After 12 weeks the femora were harvested, radiographed, and scanned with high voltage, high resolution microCT. The microCT images enable volumetric quantification of the bone density within a 2.5mm radius of the implant perimeter. Subsequent undecalcified thin section histology enabled quantification of bone apposition and bone ingrowth using backscattered scanning electron microscopy (BSEM). Statistical comparisons between control/AA-dosed implants and between low dose/high dose implants were made using paired and upaired student's t tests with p<0.05.

During this seminar presentation, I will provide more background information on the topic of bisphosphonate use in arthroplasty surgery,  the current results and findings from this study, their significance, and its potential for clinical application. 

A list of upcoming seminars can be found at : http://www.mcgill.ca/bme/news/seminars

See you there

Christophe Grova

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Christophe Grova, PhD
Assistant Professor
Biomedical Engineering Dpt
Neurology and Neurosurgery Dpt
Montreal Neurological Institute
Centre de Recherches en Mathématiques
Biomedical Engineering Department - Room 304
McGill University
3775 University Street, Montreal, Quebec, Canada, H3A 2B4
email : christophe.grova at mcgill.ca<mailto:christophe.grova at mcgill.ca>
tel : (514) 398 2516
fax : (514) 398 7461

web:
http://www.mni.mcgill.ca/research/gotman/members/christophe.html
http://www.bmed.mcgill.ca/
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