[BIC-announce] Seminar in Biomedical Engineering - WednesdayNovember 30th at 13h

[Christophe Grova]

Dear all, 

Our  next Biomedical Engineering Dpt seminar is next wednesday

Wednesday - November 30th,  at 13h
 
Location: Room  333 Lyman Duff Building (Biomedical Engineering Dpt). 

Speaker:  Dr. Mathieu Dehaes, Ph.D. Postdoctoral fellow, Harvard Medical School & Children’s Hospital Boston, Boston, MA, USA


Title: Potential of Bedside CMRO2 to Assess and Monitor Neonatal Brain Health


Abstract:
Hypoxic ischemic encephalopathy (HIE) remains a common cause of infant morbidity, occurring in 6 per 1,000 live births per year, which represents more than 26,000 cases. As for HIE, brain injury in premature infants is an important public health problem (> 63,000 born with a very low birth weight) because of the large number of infants who survive with neurodevelopmental outcomes including major cognitive deficits and serious motor disabilities. Currently, brain health monitoring for acute hypoxic ischemic brain injury is performed with bedside continuous wave near infrared spectroscopy (CWNIRS) measures of frontal brain relative tissue oxygen saturation (rStO2). These rStO2 measures are used to guide treatment decisions as individualized car for undergoing a hypothermia treatment. Although oxygen is the primary fuel for neurons, rStO2 does not reflect the amount of oxygen consumed by neurons, and is affected by multiple non-neuronal factors such as blood flow and hematocrit. In this presentation, we will show that StO2 is insensitive to brain growth in normal preterm and term children, and is insensitive to acute hypoxic ischemic brain injury in neonates. Also, we will demonstrate that the use of bedside frequency domain NIRS (FDNIRS) combined with diffuse correlation spectroscopy (DCS) provide direct measures of neuronal health by providing absolute measures of neuronal cerebral oxygen consumption (CMRO2). We will show the potential of bedside FDNIRS-DCS measures of CMRO2 to assess preoperative brain health and monitor for postoperative hypoxic ischemic brain injury in neonates who underwent an open-heart surgery for congenital heart disease. Our goal is to establish bedside FDNIRS-DCS as a safe and informative bedside tool for assessing and monitoring brain health in neonates with hypoxic ischemic insults and then improve neurodevelopmental outcomes.


A list of upcoming seminars can be found at : http://www.bme.mcgill.ca/seminars.html



See you there



Christophe Grova 



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Christophe Grova, PhD 
Assistant Professor
Biomedical Engineering Dpt 
Neurology and Neurosurgery Dpt 

Montreal Neurological Institute
Centre de Recherches en Mathématiques

Biomedical Engineering Department - Room 304
McGill University
3775 University Street, Montreal, Quebec, Canada, H3A 2B4
email : christophe.grova at mcgill.ca
tel : (514) 398 2516
fax : (514) 398 7461
 
web: 
http://www.mni.mcgill.ca/research/gotman/members/christophe.html
http://www.bmed.mcgill.ca/
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