[BIC-announce] FW: Killam Lecture - TODAY Lysophospholipid Receptors: roles in the CNS and Multiple Sclerosis

[Jennifer Chew, Ms.]

PLEASE DISCARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER

Jennifer Chew
McConnell Brain Imaging Centre
MNI - WB317
3801 University Street
Montreal, Qc  H3A 2B4
Telephone:  514-398-8554
Fax:  514-398-2975



________________________________
From: MNISTAFF - Montreal Neurological Institute Staff [mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Enza Ferracane, Ms.
Sent: Monday, March 28, 2011 8:58 AM
To: MNISTAFF at LISTS.MCGILL.CA
Subject: Killam Lecture - TODAY


Killam Lecture



Speaker:  Jerold Chun, PhD

Department of Pharmacology

Scripps Research Institute, University of California, San Diego



Title:  Lysophospholipid Receptors:  Roles in the CNS and Multiple Sclerosis



Date:  TODAY



Time:  4pm



Place:  de Grandpre Communications Centre

============================================

Jerold Chun is a professor in the Department of Molecular Biology at the Scripps Research Institute and adjunct professor at UCSD. His Killam presentation will focus on his leading edge studies of the receptor-mediated effects of naturally occurring lysophopholipids, namely lysophosphatidic acid (LPA) and sphingosine-1 phosphate (S1P). The S1P receptor agonist FTY720 has just been approved as a clinical therapy for relapsing forms of multiple sclerosis based on its observed immunologic actions. The drug readily accesses the CNS. His presentation will review the mechanisms of action of FTY on the immune systems and detail his recent studies that used genetic manipulation of S1P receptor on glial cells to show how modulating S1P receptor signaling can impact both on tissue injury and repair within the CNS.



1.The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.<http://www.ncbi.nlm.nih.gov/pubmed/21339490> Soliven B, Miron V, Chun J.  Neurology. 2011 Feb 22;76(8 Suppl 3):S9-14.



2.FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation.<http://www.ncbi.nlm.nih.gov/pubmed/21177428>   Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):751-6


Enza Ferracane
Montreal Neurological Institute
3801 University
Montreal, Quebec  H3A 2B4
Director's Office, Rm 636
Tel: (514) 398-1903
Fax:  (514) 398-8248
Email: enza.ferracane at mcgill.ca<mailto:enza.ferracane at mcgill.ca>


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