[BIC-announce] FW: Killam Lecture - TODAY - Huntington's Disease: From Axonal Transport to Ciliogenesis

Tue Nov 2 09:25:17 EDT 2010

PLEASE DISCARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER 

Jennifer Chew

McConnell Brain Imaging Centre

MNI - WB317

3801 University Street

Montreal, Qc  H3A 2B4

Telephone:  514-398-8554

Fax:  514-398-2975

________________________________

From: MNISTAFF - Montreal Neurological Institute Staff [mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Enza Ferracane, Ms.
Sent: Tuesday, November 02, 2010 8:35 AM
To: MNISTAFF at LISTS.MCGILL.CA
Subject: Killam Lecture - TODAY

*****REMINDER****

Killam Lecture

Dear Colleagues:

Our Killam speaker for tomorrow November 2nd at 4:00 p.m. in the de Grandpré Communications Centre <http://neuromedia.mcgill.ca/mnibooking/week.php?year=2007&month=09&day=07&area=3&room=4>  (MNI), is Dr. Fréderic Saudou from the Institut Curie, Université Paris-Sud, France.

The title of his talk is:   Huntington's Disease: From Axonal Transport to Ciliogenesis

Dr Frédéric Saudou, Director of the Signalisation, neurobiologie et cancer unit <http://www.curie.fr/recherche/themes/detail_unites.cfm/lang/_gb/id/57.htm> at Institut Curie i <http://www.curie.fr/recherche/themes/detail_unites.cfm/lang/_gb/id/57.htm> n Paris. Dr Saudou works on Huntington's disease (HD), an autosomal dominant disease due to the abnormal expansion of a polyglutamine repeat (polyQ) in the protein huntingtin. HD is a neurodegenerative disease characterized by abnormal apoptosis of neurons in part of the brain called the striatum. Dr Saudou's group studies the molecular mechanisms and signal transduction pathways controlling neuronal death in HD. He has made important contribution into understanding how phosphorylation and trafficking of Huntingtin contributes to HD pathogenesis. Frédéric is an engaging speaker. I hope you will join us for his seminar entitled "Huntington's disease: From axonal transport to ciliogenesis".

I look forward to seeing you all there.

Ted Fon

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Speaker:  Fréderic Saudou, PhD

Title:   Huntington's Disease: From Axonal Transport to Ciliogenesis

Date:  TODAY

Time:  4:00 p.m.

Place:  de Grandpré Communications Centre

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Selected publications:

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. <http://www.ncbi.nlm.nih.gov/pubmed/20696378> 

Godin JD, Colombo K, Molina-Calavita M, Keryer G, Zala D, Charrin BC, Dietrich P, Volvert ML, Guillemot F, Dragatsis I, Bellaiche Y, Saudou F, Nguyen L, Humbert S.

Neuron. 2010 Aug 12;67(3):392-406.

pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking. <http://www.ncbi.nlm.nih.gov/pubmed/20515468> 

Pardo R, Molina-Calavita M, Poizat G, Keryer G, Humbert S, Saudou F.

Mol Brain. 2010 Jun 1;3:17.

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. <http://www.ncbi.nlm.nih.gov/pubmed/20152113> 

Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, MacAskill AF, Rostaing P, Lumb MJ, Humbert S, Triller A, Saudou F, Yan Z, Kittler JT.

Neuron. 2010 Jan 14;65(1):53-65.

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease. <http://www.ncbi.nlm.nih.gov/pubmed/19860865> 

Pineda JR, Pardo R, Zala D, Yu H, Humbert S, Saudou F.

Mol Brain. 2009 Oct 27;2(1):33.

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. <http://www.ncbi.nlm.nih.gov/pubmed/18772195> 

Zala D, Colin E, Rangone H, Liot G, Humbert S, Saudou F.

Hum Mol Genet. 2008 Dec 15;17(24):3837-46. Epub 2008 Sep 4.

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. <http://www.ncbi.nlm.nih.gov/pubmed/18615096> 

Colin E, Zala D, Liot G, Rangone H, Borrell-Pagès M, Li XJ, Saudou F, Humbert S.

EMBO J. 2008 Aug 6;27(15):2124-34. Epub 2008 Jul 10.

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons. <http://www.ncbi.nlm.nih.gov/pubmed/17611284> 

Anne SL, Saudou F, Humbert S.

J Neurosci. 2007 Jul 4;27(27):7318-28.

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. <http://www.ncbi.nlm.nih.gov/pubmed/17392473> 

Dompierre JP, Godin JD, Charrin BC, Cordelières FP, King SJ, Humbert S, Saudou F.

J Neurosci. 2007 Mar 28;27(13):3571-83.

The ataxia-ome: connecting disease proteins of the cerebellum. <http://www.ncbi.nlm.nih.gov/pubmed/16713557> 

Humbert S, Saudou F.

Cell. 2006 May 19;125(4):645-7.

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421. <http://www.ncbi.nlm.nih.gov/pubmed/16452687> 

Pardo R, Colin E, Régulier E, Aebischer P, Déglon N, Humbert S, Saudou F.

J Neurosci. 2006 Feb 1;26(5):1635-45.