[BIC-announce] FW: Special Lecture - Monday, March 17, 2008 - CRMP-2, Slp 1 and Rab27B Mediate anterograde Transport of TrkB in Axons

[Jennifer Chew, Ms.]

  PLEASE DISCARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER  

Special Lecture, Monday March 17th, 11 am 
BTRC, de Grand Pre Conference Room,
Montreal Neurological Institute. 

Title:  CRMP-2, Slp1 and Rab27B Mediate Anterograde Transport of TrkB in
Axons.
Dr. Nariko Arimura
Dept of Cell Pharmacology
Nagoya University, Japan

Abstract:

Dramatic membrane recruitment to the tips of neurites occurs during
neuronal development, which allows neurite to increase their total
membranous components and cell surface proteins. Here we report that
CRMP-2, Slp1, and Rab27B form a complex, and mediate the anterograde
transport of TrkB, which is an essential survival signal. The
CRMP-2/Slp1 complex directly interacts with the light chain of
Kinesin-1. This interaction may be a regulatory point, and enable the
selective recruitment of TrkB toward axon terminal.


Recent Papers by Dr Arimura include the following: 


Arimura N and Kaibuchi K (2007) Neuronal polarity: from extracellular
signals to intracellular mechanisms. Nat Rev Neurosci. Mar;8(3):194-205.

 

Yoshimura T, Arimura N and Kaibuchi K  (2006) Signaling networks in
neuronal polarization. J Neurosci. Oct 18;26(42):10626-30.

 

Arimura N and Kaibuchi K (2005) Key regulators in neuronal polarity.
Neuron. Dec 22;48(6):881-4.

 

If you are interested in meeting with Dr. Arimura, please contact Tim
Kennedy (398-7136, timothy.kennedy at mcgill.ca).

 

 

 

 

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