[BIC-announce] FW: Killam Lecture - Today - Movement Molecules, Molecular Pathways of Motor System Disease

[Jennifer Chew, Ms.]

PLEASE DISCARD IF THIS IS A DUPLICATE.  JENNIFER 
 
________________________________

From: MNISTAFF - Montreal Neurological Institute Staff
[mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Enza Ferracane, Ms.
Sent: Tuesday, January 22, 2008 8:50 AM
To: MNISTAFF at LISTS.MCGILL.CA
Subject: Killam Lecture - Today

*****REMINDER*****

 KILLAM LECTURE

Speaker:  Willam Dauer, MD, Departments of Neurology and Pharmacology,
Columbia University Neurological Institute of New York

Title:  Movement Molecules, Molecular Pathways of Motor System Disease

Date:  January 22, 2008

Time:  4:00 pm

Place:  de Grandpre Communications Centre

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Dear Colleagues,

The Killam speaker this week will be Dr William Dauer from Columbia
University. Bill studies the molecular and cellular mechanisms of
diseases that disrupt the motor system. His primary focus is on
Parkinson's disease and DYT1 dystonia. For each of these projects, they
focus their efforts on disease genes that cause these disorders,
employing a range of molecular, cellular, and whole animal studies to
dissect the normal role of disease proteins, and how pathogenic
mutations lead to disease. Recent work includes understanding the
functions of LRRK2 in PARK8-linked Parkinson's disease. Bill's group
also discovered that the DYT1 dystonia-causing torsinA mutation produces
a dramatic re-localization of torsinA from the endoplasmic reticulum to
the nuclear envelope where it is likely to be a key factor in disease
pathogenesis. His recent papers include:

Weisstaub NV et al. Cortical 5-HT2A receptor signaling modulates
anxiety-like behaviors in mice. Science. 2006 Jul 28;313(5786):536-40.

Goodchild RE, Kim CE, Dauer WT. Loss of the dystonia-associated protein
torsinA selectively disrupts the neuronal nuclear envelope. Neuron. 2005
Dec 22;48(6):923-32.

Goodchild RE, Dauer WT. The AAA+ protein torsinA interacts with a
conserved domain present in LAP1 and a novel ER protein. J Cell Biol.
2005 Mar 14;168(6):855-62.

Stefanis L, Wang Q, Oo T, Lang-Rollin I, Burke RE, Dauer WT. Lack of
alpha-synuclein does not alter apoptosis of neonatal catecholaminergic
neurons. Eur J Neurosci. 2004 Oct;20(7):1969-72.

Goodchild RE, Dauer WT. Mislocalization to the nuclear envelope: an
effect of the dystonia-causing torsinA mutation. Proc Natl Acad Sci U S
A. 2004 Jan 20;101(3):847-52. 


Bill is a very engaging speaker. Please join us for what promises to be
a very interesting seminar.
 
Ted

-------------------------

Edward A. Fon, MD, FRCP(C)
Killam Scholar
Montreal Neurological Institute
Associate Professor
McGill University
Office: (514) 398-8398
Lab: (514) 398-5057
Fax: (514) 398-5214
ted.fon at mcgill.ca
http://www.mni.mcgill.ca/neuro_team/neuronal_survival/edward_fon/

 

 

Enza Ferracane

Montreal Neurological Institute

3801 University

Montreal, Quebec  H3A 2B4

Director's Office, Rm 636

(514) 398-1903