[BIC-announce] FW: Reminder: Killam Lecture - Today @ 4:00 pm - Speaker: Dr. Stephen Cannon- Myotonia and Periodic Paralysis: A Model system for Understanding Channelopathies

[Jennifer Chew, Ms.]

PLEASE DISCARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER 
 
________________________________

From: MNISTAFF - Montreal Neurological Institute Staff [mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Felicia Callocchia, Ms.
Sent: Tuesday, May 29, 2007 9:43 AM
To: MNISTAFF at LISTS.MCGILL.CA
Subject: Reminder: Killam Lecture - Today @ 4:00 pm - Speaker: Dr. Stephen Cannon



REMINDER

 

KILLAM LECTURE

 

Speaker:           Stephen Cannon, MD, PhD

                        Chairman, Neurology

                        Southwestern Medical Center (University of Texas)

 

Title:                 Myotonia and Periodic Paralysis:  A Model System for Understanding Channelopathies

 

Place:               de Grandpre Communications Centre

 

Date:                Tuesday, May 29, 2007

 

Time;                4:00 pm

 

________________________________

 

The Killam Seminar Speaker for Tuesday, May 29th will be Dr. Steve Cannon, Professor And Chairman, Department of Neurology UT Southwestern Medical Center at Dallas

 

Killam Seminars are held at 4:00 pm in the de Grandpré Communications Centre, Brain Tumor Research Centre, MNI. 

  

Over the years, Steve has carried out pioneering work on characterizing channelopathies and neurological disease. Dr. Cannon's lab is interested in gaining a better understanding of how ion channels regulate electrical excitability of cells and of how defects in these channels lead to human disease. In the past decade, mutations of ion channel genes have been found for inherited diseases that cause episodic paralysis, familial migraine, episodic ataxia, fatal cardiac arrhythmias, and some forms of epilepsy. Dr. Cannon has been studying the consequences of mutations in sodium, calcium, and chloride channels that have been linked to muscle disorders causing episodic paralysis or stiffness (myotonia). Many disease-associated mutations alter the tendency for a channel to open or close (gating behavior), and another interest of his lab is fundamental mechanisms of sodium channel gating.

 

Cannon SC. Pathomechanisms in Channelopathies of Skeletal Muscle and Brain. Annu Rev Neurosci. 2006 Mar 21; [Epub ahead of print

 

Venance SL, Cannon SC, Fialho D, Fontaine B, Hanna MG, Ptacek LJ, Tristani-Firouzi M, Tawil R, Griggs RC; CINCH investigators. The primary periodic paralyses: diagnosis, pathogenesis and treatment. Brain. 2006 Jan;129(Pt 1):8-17

 

Wu FF, Gordon E, Hoffman EP, Cannon SC. A C-terminal skeletal muscle sodium channel mutation associated with myotonia disrupts fast inactivation. J Physiol. 2005 Jun 1;565(Pt 2):371-80

 

Berg J, Jiang H, Thornton CA, Cannon SC. Truncated ClC-1 mRNA in myotonic dystrophy exerts a dominant-negative effect on the Cl current. Neurology. 2004 Dec 28;63(12):2371-5.

 

Cannon SC. Paying the price at the pump: dystonia from mutations in a Na+/K+ -ATPase. 

Neuron. 2004 Jul 22;43(2):153-4.

 

Struyk, A.S. and Cannon, S.C., "The human skeletal muscle Na channel mutation R669H associated with hypokalemic periodic paralysis enhances slow inactivation" J. Neurosci, 20:8610-8617, 2000

 

  

Sincerely, 

  

Amit Bar-Or