[BIC-announce] FW: David Park Killam

[Jennifer Chew, Ms.]

PLEASE DISCARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER 
 

________________________________

From: MNISTAFF - Montreal Neurological Institute Staff
[mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Enza Ferracane, Ms.
Sent: Monday, June 04, 2007 11:59 AM
To: MNISTAFF at LISTS.MCGILL.CA
Subject: David Park Killam

Dear colleagues,
 
The Killam speaker this week is Dr David Park from the Ottawa Health
Research Institute (OHRI), University of Ottawa. Dr Park investigates
the signaling pathways which control neuronal death in Parkinson's
disease (PD). His group has taken the lead in developing in vitro,
cellular and animal models of neuronal death related to trophic factor
deprivation, DNA damage, cell cycle, caspases and stress activated c-Jun
kinase. Dr Park has been extremely productive, making some seminal
contributions to our understanding of PD pathogenesis. His recent
publications include:

Mount MP et al. Involvement of interferon-gamma in microglial-mediated
loss of dopaminergic neurons. J Neurosci. 2007 27(12):3328. 

Zhang Y et al. The Chk1/Cdc25A pathway as activators of the cell cycle
in neuronal death induced by camptothecin. J Neurosci. 2006 26(34):8819.

Smith PD et al. Calpain-regulated p35/cdk5 plays a central role in
dopaminergic neuron death through modulation of the transcription factor
myocyte enhancer factor 2. J Neurosci. 2006 26(2):440. 

O'Hare MJ, et al. Differential roles of nuclear and cytoplasmic
cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. J
Neurosci. 2005 25(39):8954.

Rashidian J et al.  Multiple cyclin-dependent kinases signals are
critical mediators of ischemia/hypoxic neuronal death in vitro and in
vivo. Proc Natl Acad Sci U S A. 2005 102(39):14080.

Kim RH et al. Hypersensitivity of DJ-1-deficient mice to
1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative
stress. Proc Natl Acad Sci U S A. 2005 102(14):5215.

Kalia SK et al. BAG5 inhibits parkin and enhances dopaminergic neuron
degeneration. Neuron. 2004 44(6):931.

Aleyasin H et al. Nuclear factor-(kappa)B modulates the p53 response in
neurons exposed to DNA damage. J Neurosci. 2004 24(12):2963. 
   
Hayley S et al. Regulation of dopaminergic loss by Fas in a
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's
disease. J Neurosci. 2004 Feb 25;24(8):2045. 


David is a very engaging speaker. Please join us for what promises to be
a very interesting seminar.
 
Ted

------------------
Edward A. Fon, MD, FRCP(C)
Killam Scholar
Montreal Neurological Institute
Associate Professor
McGill University
Office: (514) 398-8398
Lab: (514) 398-5057
Fax: (514) 398-5214
ted.fon at mcgill.ca
http://www.mni.mcgill.ca/cfns.html#EdwardFon