[BIC-announce] FW: Killam Lecture - Tuesday, January 23, 2007 @ 4:00 pm - Speaker: Dr. Roman Giger - Spinal Cord Injury Research: Molecular Analysis of Inhibitors of Axonal Regeneration

Fri Jan 19 14:00:15 EST 2007

 PLEASE DISCARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER 

Jennifer Chew

McConnell Brain Imaging Centre

MNI - WB317

3801 University Street

Montreal, Qc  H3A 2B4

Telephone:  514-398-8554

Fax:  514-398-2975

 KILLAM LECTURE

Speaker:    Roman Giger, Ph.D.
                   Department of Biomedical Genetics
                   University of Rochester Medical Center

Title:            Spinal Cord Injury Research:  Molecular Analysis of
Inhibitors of Axonal Regeneration

Place:          de Grandpre Communications Centre

Date:           Tuesday, January 23, 2007

Time:           4:00 pm

________________________________

Dear Colleagues,  

Dr. Roman Giger will be visiting to give the Killam seminar on Tuesday
January 23rd entitled "Spinal Cord Injury Research: Molecular Analysis
of Inhibitors of Axonal Regeneration".  Roman is an Associate professor
in Neurology in the Department of Biomedical Genetics at the University
of Rochester.  His research focusses on understanding the molecular and
cellular mechanisms of repulsive axon guidance in the developing and
regenerating mammalian nervous system.  There is growing evidence that
the molecular mechanisms that underlie the sculpting of neuronal
networks during development also apply to aspects of adult neuronal
plasticity and repair following injury. Much progress has been made in
identifying molecules that regulate axonal pathfinding but still little
is known about how these molecules directly contribute to the wiring and
maintenance of complex neuronal connectivity in vivo. Using a genetic
approach, Roman's research aims to elucidate the mechanisms that govern
the assembly of specific neural networks. Understanding the principles
of network assembly will have important implications for the development
of strategies aimed to promote neural repair following trauma or
disease.  A link to his webpage and some recent publications are
provided below.  We look forward to seeing you at what should be an
exciting Killam seminar . 

http://www.urmc.rochester.edu/GEBS/faculty/roman_giger.htm
<http://www.urmc.rochester.edu/GEBS/faculty/roman_giger.htm>  

1:  Hofer T, Tangkeangsirisin W, Kennedy MG, Mage RG, Raiker SJ,
Venkatesh K,
Lee H, Giger RJ, Rader C. 
Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66
receptor
family selected for species cross-reactivity with an improved phage
display
vector.
J Immunol Methods. 2007 Jan 10;318(1-2):75-87. Epub 2006 Nov 7. 
PMID: 17140598 [PubMed - in process]

2:  Kornack DR, Giger RJ. 
Probing microtubule +TIPs: regulation of axon branching.
Curr Opin Neurobiol. 2005 Feb;15(1):58-66. Review. 
PMID: 15721745 [PubMed - indexed for MEDLINE]

3:  Venkatesh K, Chivatakarn O, Lee H, Joshi PS, Kantor DB, Newman BA,
Mage R,
Rader C, Giger RJ. 
The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor
selective
for myelin-associated glycoprotein.
J Neurosci. 2005 Jan 26;25(4):808-22. 
PMID: 15673660 [PubMed - indexed for MEDLINE]

4:  Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ,
Flanagan
JG, Yamaguchi Y, Sretavan DW, Giger RJ, Kolodkin AL. 
Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan
and
chondroitin sulfate proteoglycans.
Neuron. 2004 Dec 16;44(6):961-75. 
PMID: 15603739 [PubMed - indexed for MEDLINE]

5:  Holtmaat AJ, Gorter JA, De Wit J, Tolner EA, Spijker S, Giger RJ,
Lopes da
Silva FH, Verhaagen J. 
Transient downregulation of Sema3A mRNA in a rat model for temporal lobe
epilepsy. A novel molecular event potentially contributing to mossy
fiber
sprouting.
Exp Neurol. 2003 Jul;182(1):142-50. 
PMID: 12821384 [PubMed - indexed for MEDLINE]

6:  Cloutier JF, Giger RJ, Koentges G, Dulac C, Kolodkin AL, Ginty DD. 
Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not
axonal
convergence, of primary accessory olfactory neurons.
Neuron. 2002 Mar 14;33(6):877-92. 
PMID: 11906695 [PubMed - indexed for MEDLINE]

7:  Giger RJ, Kolodkin AL. 
Silencing the siren: guidance cue hierarchies at the CNS midline.
Cell. 2001 Apr 6;105(1):1-4. Review. No abstract available. 
PMID: 11300996 [PubMed - indexed for MEDLINE]

8:  Pasterkamp RJ, Giger RJ, Baker RE, Hermens WT, Verhaagen J. 
Ectopic adenoviral vector-directed expression of Sema3A in organotypic
spinal
cord explants inhibits growth of primary sensory afferents.
Dev Biol. 2000 Apr 15;220(2):129-41. 
PMID: 10753505 [PubMed - indexed for MEDLINE]

9:  Giger RJ, Kolodkin AL. 
Frazzled precision guides axons.
Nature. 2000 Aug 24;406(6798):841, 843. No abstract available. 
PMID: 10972274 [PubMed - indexed for MEDLINE]

10:  Rochlin MW, O'Connor R, Giger RJ, Verhaagen J, Farbman AI. 
Comparison of neurotrophin and repellent sensitivities of early
embryonic
geniculate and trigeminal axons.
J Comp Neurol. 2000 Jul 10;422(4):579-93. 
PMID: 10861527 [PubMed - indexed for MEDLINE]

11:  Giger RJ, Cloutier JF, Sahay A, Prinjha RK, Levengood DV, Moore SE,
Pickering S, Simmons D, Rastan S, Walsh FS, Kolodkin AL, Ginty DD,
Geppert M. 
Neuropilin-2 is required in vivo for selective axon guidance responses
to
secreted semaphorins.
Neuron. 2000 Jan;25(1):29-41. 
PMID: 10707970 [PubMed - indexed for MEDLINE]