[BIC-announce] FW: Killam Lecture - Tuesday, April 18, 2006 - Protein Traffic at Nascent Neuronal Contacts

[Jennifer Chew, Ms.]

PLEASE DISCARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER 

________________________________

From: MNISTAFF - Montreal Neurological Institute Staff
[mailto:MNISTAFF at LISTS.MCGILL.CA] On Behalf Of Enza Ferracane, Ms.
Sent: Thursday, April 13, 2006 9:10 AM
To: MNISTAFF at LISTS.MCGILL.CA
Subject: Killam Lecture - Tuesday, April 18, 2006

 

Killam Lecture

 

Speaker:  Alaa El-Husseini, Ph.D.

Assistant Professor, University of British Columbia

 

Title:  Protein Traffic at Nascent Neuronal Contacts

 

Date:  Tuesday, April 18, 2006

 

Place:  de Grandpre Communication Centre

 

Time:  4:00 pm



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Next week's (April 18) Killam speaker will be Dr Alaa El-Husseini from
The Brain Centre, Dept. Psychiatry at UBC. Alaa is one of the leaders in
the study of excitatory synaptic transmission. His research focuses on
understanding protein trafficking and turnover in dendrites and its
relationship to synapse formation and function.

Alaa is interested in mechanisms that control synapse development and in
Protein Complexes at Excitatory Synapses. Specifically, his lab is
working on:

1. Control of synaptic balance between excitation and inhibition
2. Assembly of proteins at nascent neuronal contacts
3. Protein sorting and trafficking
4. Regulation of protein sorting and function by palmitoylation

As you can see, Alaa has published several high impact papers in the
past 2 years:

Gerrow, K., Romorini, S., Nabi, S. M., Colicos, M. A., Sala, C., and
El-Husseini, A. (2006). A preformed complex of postsynaptic proteins is
involved in excitatory synapse development. Neuron 49, 547-562.

Lise, M. F., Wong, T. P., Trinh, A., Hines, R. M., Liu, L., Kang, R.,
Hines, D. J., Lu, J., Goldenring, J. R., Wang, Y. T., and El-Husseini,
A. (2006). Involvement of Myosin Vb in glutamate receptor trafficking. J
Biol Chem 281, 3669-3678.

Levinson, J. N., Chery, N., Huang, K., Wong, T. P., Gerrow, K., Kang,
R., Prange, O., Wang, Y. T., and El-Husseini, A. (2005). Neuroligins
Mediate Excitatory and Inhibitory Synapse Formation: involvement of
PSD-95 and neurexin-1{beta} in neuroligin-induced synaptic specificity.
J Biol Chem 280, 17312-17319.

Huang, K., Yanai, A., Kang, R., Arstikaitis, P., Singaraja, R. R.,
Metzler, M., Mullard, A., Haigh, B., Gauthier-Campbell, C., Gutekunst,
C. A., et al. (2004). Huntingtin-Interacting Protein HIP14 Is a
Palmitoyl Transferase Involved in Palmitoylation and Trafficking of
Multiple Neuronal Proteins. Neuron 44, 977-986.

Prange, O., Wong, T. P., Gerrow, K., Wang, Y. T., and El-Husseini, A.
(2004). A balance between excitatory and inhibitory synapses is
controlled by PSD-95 and neuroligin. PNAS 101, 13915-13920.

Kang, R., Swayze, R., Lise, M. F., Gerrow, K., Mullard, A., Honer, W.
G., and El-Husseini, A. (2004). Presynaptic trafficking of synaptotagmin
I is regulated by protein palmitoylation. J Biol Chem 279, 50524-50536.

Gauthier-Campbell, C., Bredt, D. S., Murphy, T. H., and El-Husseini, A.
E.-D. (2004). Regulation of Dendritic Branching and Filopodia Formation
in Hippocampal Neurons by Specific Acylated Protein Motifs. Mol Biol
Cell 15, 2205-2217.

I hope you will join me for his seminar.

Ted

-------------------------

Edward A. Fon
Assistant Professor
Montreal Neurological Institute
McGill University
Office: (514) 398-8398
Lab: (514) 398-5057
Fax: (514) 398-5214
ted.fon at mcgill.ca

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