[BIC-announce] FW: This Week's Killam Speaker - Endosomes, Intracellular sorting, and Plasticity Mechanisms at Glutamatergic Synapes

[Jennifer Chew, Ms.]

 PLEASE DISCARD IF THIS IS A DUPLICATE.  THANK YOU.  JENNIFER 

Tuesday's Killam Speaker: Dr. Michael Ehlers
Title: Endosomes, Intracellular Sorting, and Plasticity Mechanisms at
Glutamatergic Synapes
4 PM, De Grandpre Communications Centre
Refreshments served at 3:45 PM

Dear Colleagues:

This week's Killam speaker will be Dr Michael Ehlers, Associate
Professor, Deptartments of Neurobiology, Duke University. Mike is one of
the leaders in the study of excitatory synaptic transmission. His
research focuses on understanding protein trafficking and turnover in
dendrites and its relationship to synapse formation and function.

There are three major lines of ongoing research in his lab. First, he is
studying the molecular and cellular mechanisms that regulate the
trafficking of ionotropic glutamate receptors to and from the synapse.  
Second, he is studying the dynamics and regulation of the endocytic
machinery in dendrites and dendritic spines. Third, he is working to
determine how protein stability is controlled at the postsynaptic
membrane and, in particular, investigating the role of the
ubiquitin-proteasome system in postsynaptic remodeling.

As you can see, Mike is a prolific writer:

Park M, Penick EC, Edwards JG, Kauer JA, Ehlers MD.
Recycling endosomes supply AMPA receptors for LTP.
Science. 2004 Sep 24;305(5692):1972-5.

Scott DB, Michailidis I, Mu Y, Logothetis D, Ehlers MD.
Endocytosis and degradative sorting of NMDA receptors by conserved
membrane-proximal signals.
J Neurosci. 2004 Aug 11;24(32):7096-109

Mu Y, Otsuka T, Horton AC, Scott DB, Ehlers MD.
Activity-dependent mRNA splicing controls ER export and synaptic
delivery of NMDA receptors.
Neuron. 2003 Oct 30;40(3):581-94.

Horton AC, Ehlers MD.
Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites
revealed by live-cell imaging.
J Neurosci. 2003 Jul 16;23(15):6188-99.

Ehlers MD.
Activity level controls postsynaptic composition and signaling via the
ubiquitin-proteasome system.
Nat Neurosci. 2003 Mar;6(3):231-42.

Blanpied TA, Scott DB, Ehlers MD.
Dynamics and regulation of clathrin coats at specialized endocytic zones
of dendrites and spines.
Neuron. 2002 Oct 24;36(3):435-49.

Reviews:

Horton AC, Ehlers MD.
Secretory trafficking in neuronal dendrites.
Nat Cell Biol. 2004 Jul;6(7):585-91. Review.

Ehlers MD.
Eppendorf 2003 prize-winning essay. Ubiquitin and the deconstruction of
synapses.
Science. 2003 Oct 31;302(5646):800-1.

Horton AC, Ehlers MD.
Neuronal polarity and trafficking.
Neuron. 2003 Oct 9;40(2):277-95. Review

Mike is also a very engaging speaker. Please join us for what promises
to be a very exciting Killam talk by Dr Ehlers.

Ted