[Ace-recruitment] IBIS Network - Week In Review - 3/14/2025

[Chappell, Chad]

IBIS Week In Review
3/14/2025

IBIS Executive Committee
Approvals
Austin Ferguson, John Pruett, and team
6mo fcMRI-EEG Peak Alpha Frequency/Weighted Mean Frequency Correlates
For the 6m age group, we will instead explore two measures chosen as proxies for PAF. Weighted
mean frequency (WMF) measures the 'center of mass' of the power distribution as a function of
frequency over a particular frequency band. Abby Dickenson has found that the WMF over the
alpha band (6-9Hz) highly correlates with PAF (for subjects who have developed PAF), and that
WMF over the transition band (4.5-7.5Hz) between theta and alpha strongly differentiates
between subjects who have developed PAF and those who haven't. Given that these can be
computed for all subjects, they will provide convenient measures for exploration in this age
group.

Rebecca Grzadzinski
Pupillary Reaction to Social Stimuli as a Marker of Atypical Social Arousal in Infants at High Likelihood(HL) for ASD and those with DS.
Update to already apporved project
As a part of Becca’s K award, imaging data was added to Becca's prior approved work with pupillary data.

Jessica Girault
Mapping Visual System Microstructure to Visual Processing in Infants
Abstract for a BBRF Young Investigator proposal -
Atypical visual processing is a feature of multiple neuropsychiatric disorders (NPDs) including early-onset disorders like autism spectrum disorder (ASD), as well as ADHD, schizophrenia and mood disorders that emerge later in development. Visual processing and perceptual abilities develop rapidly during infancy and impact cognition and learning, but their developmental neurobiology remains poorly understood. This BBRF project will apply novel methodological approaches to existing neuroimaging and electroencephalography datasets to examine developmental patterns of neurite density and myelination of visual circuitry in relation to macroscale neuronal firing measured across the occipital cortex in response to visual stimuli. This work is motivated by our recent converging reports of atypical visual system structural and functional development during the first year of life, and beyond, in infants at-risk for ASD. We hypothesize that microstructural changes from 6 to 12 months of age in visual circuitry will be related to individual variability in visually evoked neuronal firing patterns in a sample of more than 100 at-risk infants; one third of whom will go on to develop an NPD. Findings from this project will further our understanding of neural mechanisms that support rapid gains in visual processing across the first year of life and has the potential to inform targets and timing for early interventions centered on a highly plastic sensory system. Future directions for this program of research include longitudinal investigations linking early visual circuit properties to later brain function and neuropsychiatric traits including ASD symptoms, attention problems, and anxiety that will be measured as this cohort is followed into school-age.


IBIS Annual Meeting 2025
May 29 (~9-5:00) & May 30 (~9-12:00)
UMN
Minneapolis, MN
Our group Hotel is The Graduate
Please make your reservations with this link<https://book.passkey.com/e/50972604>
-Or call the hotel at (612) 379-8888, press 2 for reservations, & request the IBIS Autism Research Meeting 2025 room block
-Please book a room for the nights of 5/28 and 5/29 (at least).
More details to come.  Stay tuned!

Have a super weekend!

Chad
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