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<p class="xmsonormal"><b><span style="font-size:14.0pt;font-family:"Arial",sans-serif;color:black;letter-spacing:.4pt;background:white">Surgical Data Science for Decision Making Support and Knowledge Discovery in Deep Brain Stimulation</span></b><o:p></o:p></p>
<p class="xmsonormal"><b> </b><o:p></o:p></p>
<p class="xmsonormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Pierre Jannin</span></b><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">INSERM Research Director, Medical School of the University of Rennes, France<o:p></o:p></span></p>
<p class="xmsonormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="xmsonormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Wednesday, November 2, 2022</span></b><o:p></o:p></p>
<p class="xmsonormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">4 p.m. EDT</span></b><o:p></o:p></p>
<p class="xmsonormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">The Neuro, 3801 rue University, De Grandpr<span style="color:black;background:white">é</span> Communications Centre</span></b><o:p></o:p></p>
<p class="xmsonormal"><span style="font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="xmsonormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><a href="https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.eventbrite.ca%2Fe%2Ffeindel-brain-and-mind-seminar-pierre-jannin-lecture-tickets-428669591287&data=05%7C01%7Cgiulia.delguerciogreen%40mcgill.ca%7C478fe09672c743d94aff08dabb624b19%7Ccd31967152e74a68afa9fcf8f89f09ea%7C0%7C0%7C638028328097186561%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=J%2BL4nxVlZE36Kcfje6BxJkzKh7nnXrN%2B2f2zFtwh1A4%3D&reserved=0"><span style="color:#0563C1">You
must register</span><span style="color:#0563C1;font-weight:normal"> </span><span style="color:#0563C1">here to attend in person</span></a></span></b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">
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<p class="xmsonormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> </span></b><o:p></o:p></p>
<p class="xmsonormal" style="text-align:justify"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Abstract</span></b>:
<span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black;background:white">
High frequency and continuous electrical stimulation of deep brain structures (DBS) has been demonstrated as an efficient minimally invasive surgical treatment for motor related diseases and recently for severe neuropsychological diseases. The quality of the
clinical improvement, as well as the occurrence of motor, neuropsychological or psychiatric side effects strongly depend on the location of the electrodes. However, even though DBS provides excellent clinical results, there is no consensus in the neurosurgical
community about the optimal location of the area to be stimulated as well as corresponding electrical parameters. It is also expected that this is different among patients. The choice of the best target is usually based on a combination of patient specific
and generic anatomical, functional and clinical information and knowledge. Patient specific data and information are based on multimodal medical images, clinical and electrophysiological data, whereas most of the generic information and knowledge are implicit.
To make it explicit, some groups suggested digital atlases; some atlases were computed from population analysis.<o:p></o:p></span></p>
<p class="xmsonormal" style="text-align:justify"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black;background:white"><o:p> </o:p></span></p>
<p class="xmsonormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:black;background:white">In this talk, I will introduce the surgical data science approach we studied, implemented and validated in the context of Deep Brain Stimulation.
The main characteristics of our approach include: 1) computation of pre, intra and post-operative patient-specific models from multimodal medical images, clinical and electrophysiological data, 2) analysis of patient population for outlining common patterns
and outcome, and 3) computation of generic models from population analysis to help pre, intra and post operative decisions and actions. It aims both at assisting surgical planning, performance and post operative programming and evaluation, as well as better
understanding neurological phenomenon for knowledge discovery. Our approach is based on numeric and symbolic surgical data analysis. The clinical motivation is to improve targeting and post operative evaluation for better outcome and reduced side effects.</span> <o:p></o:p></p>
<p class="xmsonormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="xmsonormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">The Feindel Seminar Series at The Neuro</span></b><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Advances the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight
the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.</span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"> </span><o:p></o:p></p>
<p class="xmsonormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual
forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.</span><o:p></o:p></p>
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<h1 style="margin:0in"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;font-weight:normal"> </span><o:p></o:p></h1>
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<p class="xmsonormal" style="text-align:justify;line-height:115%"><b><span style="font-size:12.0pt;line-height:115%;font-family:"Arial",sans-serif;color:black">Contact:</span></b><span style="font-size:12.0pt;line-height:115%;font-family:"Arial",sans-serif;color:black"> </span><a href="mailto:sasha.kelly@mcgill.ca"><span style="font-size:12.0pt;line-height:115%;font-family:"Arial",sans-serif;color:#0563C1">Sasha
Kelly</span></a><span style="font-size:12.0pt;line-height:115%;font-family:"Arial",sans-serif">, Conference and Events Coordinator, The Neuro</span><o:p></o:p></p>
<p style="margin-bottom:7.5pt;line-height:15.0pt"><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><img border="0" width="960" height="187" style="width:10.0in;height:1.9444in" id="x_Picture_x0020_4" src="cid:image009.png@01D8CCE0.E8E6CC90"></span><o:p></o:p></p>
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