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<div dir="auto"><span style="font-family:Arial">Happening in 10 mins </span><br /></div>

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<div name="messageReplySection">On Apr 5, 2023, 5:03 PM -0400, Boris Bernhardt <boris.bernhardt@mcgill.ca>, wrote:<br />

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<div dir="auto"><span style="font-family:Arial">Hi BIC & FYI - post easter Feindel Lecture </span><br />

<br />

<strong><u>Special time: Tuesday April 11, 1:30 p.m</u></strong><br />

<br />

Best wishes <br />

Boris </div>

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<div name="messageReplySection">---------- Forwarded message ----------<br />

<b>From:</b> NeuroEvents <events.neuro@MCGILL.CA><br />

<b>Date:</b> Apr 5, 2023, 4:59 PM -0400<br />

<b>To:</b> MNISTAFF@LISTS.MCGILL.CA <MNISTAFF@LISTS.MCGILL.CA><br />

<b>Subject:</b> Neuro Event: Feindel Seminar - Bridging the Gap Between BigBrain and Functional MRI in Humans Using Biophysical Generative Models - April 11, 1:30 p.m<br />

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<p class="MsoNormal"><a href="https://mcgill.ca/neuro/" originalsrc="https://mcgill.ca/neuro/" shash="KwUk+XlGipx+I2C0/F6JZRY8SLl0na3GNCqABUFNrXYfXL4TsltP/jIlpM6Iju9p3jL7BiIwc+mgVgOavk4pr4Z7VmBuSzXbIwfrzgR2Ak8qca3KBrkmH7YvzWc25E0fTS0qeNoqCo/iG3Lxl2/ThiofnFqPx8+vZEgcSd9ZJME="><span style="color:windowtext;text-decoration:none"><span style="font-size:11.0pt;color:blue"><img border="0" width="303" height="66" style="width:3.1562in;height:.6875in" id="Picture_x0020_9" src="cid:image002.jpg@01D963E7.A6F99530" alt="The Neuro's logo" /></span></span></a></p>

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<p class="MsoNormal"><a href="https://www.youtube.com/user/MontrealNeuro" originalsrc="https://www.youtube.com/user/MontrealNeuro" shash="Ul9LjRlWCYYxznSFxI+/xFbUYSRW1LjSr4nBX+uaVCd4jHEw5wJ+xOCGJ9ZY2JcoQVZOpmNGboRYwyFOHc/KMZZQlAHOPGyZHSBmbEnbr/I2APt4Q2SIQU6Ttm5cEEzSxBb/sATVeVqtrm1l2QCCrkvYBad5NYEzGehYeIRgjq0="><span style="color:windowtext;text-decoration:none"><span style="font-size:11.0pt;color:blue"><img border="0" width="28" height="28" style="width:.2916in;height:.2916in" id="Picture_x0020_5" src="cid:image007.png@01D963E7.A6F99530" alt="YouTube" /></span></span></a></p>

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<p class="MsoNormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Bridging the Gap Between BigBrain and Functional MRI in Humans Using Biophysical Generative Models*</span></b></p>

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<p class="MsoNormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif"><a href="https://medbio.utoronto.ca/faculty/uludag" originalsrc="https://medbio.utoronto.ca/faculty/uludag" shash="SbIgP5dfrwZJ5n3jWTDYVUPk8MetiF1+PKhZmWf9v6M88eFZ8MKvW6wbipdsHWzx7CV3Sqw51uyOucWF6pOXMcp4PKBmmGIz7ZnI27lWT80fwsiVCRU4XbVcxpnrv9eIFopJPId52WWwWpUvLRf2wTTOVUyeZHLFDWRNhOkm42k=">Kamil Uludag</a></span></b></p>

<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Krembil Brain Institute, Canada</span></p>

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<p class="MsoNormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">11 avril <span style="color:black">2023<br /></span> 13 h 30<span style="color:black"><br /></span> Centre de communications de Grandpré, Le Neuro, 3801, rue University</span></b></p>

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<p class="MsoNormal" style="margin-bottom:6.0pt"><i><span style="font-size:11.0pt;font-family:"Arial",sans-serif">*La présentation sera en anglais</span></i></p>

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<p class="MsoNormal"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Bridging the Gap Between BigBrain and Functional MRI in Humans Using Biophysical Generative Models</span></b></p>

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<p class="MsoNormal" style="line-height:115%"><b><span style="font-size:12.0pt;line-height:115%;font-family:"Arial",sans-serif"><a href="https://medbio.utoronto.ca/faculty/uludag" originalsrc="https://medbio.utoronto.ca/faculty/uludag" shash="SbIgP5dfrwZJ5n3jWTDYVUPk8MetiF1+PKhZmWf9v6M88eFZ8MKvW6wbipdsHWzx7CV3Sqw51uyOucWF6pOXMcp4PKBmmGIz7ZnI27lWT80fwsiVCRU4XbVcxpnrv9eIFopJPId52WWwWpUvLRf2wTTOVUyeZHLFDWRNhOkm42k=">Kamil Uludag</a></span></b></p>

<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif">Krembil Brain Institute, Canada</span></p>

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<p class="MsoNormal" style="margin-bottom:6.0pt"><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif">April 11, <span style="color:black">2023<br /></span> 1:30 p.m.<span style="color:black"><br /></span> De Grandpré Communications Centre, The Neuro, 3801, University Street</span></b></p>

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<p style="text-align:justify;line-height:15.0pt"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Abstract:</span></b> <span style="font-size:10.5pt;font-family:"Arial",sans-serif">In this talk, I will provide an overview of the physiological processes that contribute to the observed BOLD signal (i.e., the generative biophysical model), including their time course properties within the framework of the physiologically-informed dynamic causal modeling (P-DCM). Specifically, the physiological origin of the so-called BOLD signal “transients” will be discussed, including the initial overshoot, steady-state activation and the post-stimulus undershoot. I argue that incorrect physiological assumptions in the generative model of the BOLD signal can lead to incorrect inferences pertaining to both local neuronal activity and effective connectivity between brain regions. In addition, I introduce the recent laminar BOLD signal model, which extends P-DCM to cortical depths-resolved BOLD signals, allowing for laminar neuronal activity to be determined using high-resolution fMRI data. Finally, I outline a research program to leverage the BigBrain to develop brain-area specific microcircuit models, which can represent the neuronal component of the laminar fMRI signal model.</span></p>

<p style="text-align:justify;line-height:15.0pt"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">The Feindel Seminar Series at The Neuro</span></b></p>

<p class="MsoNormal" style="text-align:justify;line-height:15.0pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Advances the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.</span></p>

<p style="text-align:justify;line-height:15.0pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.</span></p>

<p style="text-align:justify;line-height:15.0pt"><span style="font-size:10.0pt;font-family:"Times New Roman",serif"><a href="https://www.eventbrite.ca/e/feindel-brain-and-mind-seminar-kamil-uludag-tickets-601471606767" originalsrc="https://www.eventbrite.ca/e/feindel-brain-and-mind-seminar-kamil-uludag-tickets-601471606767" shash="u3hkrawGEfnZmST+Nx7HPAuYe3rI2YPZUo8pgwe1uk2wTyuGECBbjVhH6wE288eyOYhMEKb2nsFgztf8gmTb55O+5hXziPwNVLtT2ZKEIHAXDjU91LpvfEq1os3m+31mERXV+EBjQbe0oFymDYBc5eSx5cGlKGShR5Rh+0UttEA="><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:windowtext">Registration required</span></b></a></span></p>

<p style="text-align:justify;line-height:15.0pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black">Contact:</span> <span style="font-size:10.5pt;font-family:"Arial",sans-serif"></span><span style="font-size:10.0pt;font-family:"Times New Roman",serif"><a href="mailto:sasha.kelly@mcgill.ca"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Sasha Kelly</span></a></span><span style="font-size:10.5pt;font-family:"Arial",sans-serif;color:black">,</span> <span style="font-size:10.5pt;font-family:"Arial",sans-serif">Conference and Events Coordinator<span style="color:black">, The Neuro</span></span></p>

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