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<p class="MsoNormal"><b><i><span style="color:#1F497D;mso-fareast-language:EN-US">Sent on behalf of Julien Doyon<o:p></o:p></span></i></b></p>
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<p class="MsoNormal"><a href="https://mcgill.ca/neuro/"><span style="color:blue;text-decoration:none"><img border="0" width="468" height="105" style="width:4.875in;height:1.0937in" id="_x0000_i1027" src="cid:image003.png@01D6CE1E.6C4D14E0" alt="The Neuro's logo"></span></a><o:p></o:p></p>
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<h3><span style="font-family:"Arial",sans-serif">Monday<span style="color:black">,
</span>December<span style="color:black"> </span>14, 2020<span style="color:black"> <br>
4:00 - 5:00PM E</span>S<span style="color:black">T<br>
Zoom <a href="https://www.eventbrite.ca/e/special-seminar-mapping-drivers-of-pathological-cognitive-aging-using-pet-tickets-131912266139" target="_blank" title="https://www.eventbrite.ca/e/killam-seminar-series-programmed-axon-death-and-its-roles-in-human-disease-tickets-124102468825">(Registration
Required)</a></span></span><o:p></o:p></h3>
<p class="MsoNormal" style="line-height:115%"><b><span style="font-size:13.5pt;line-height:115%;font-family:"Arial",sans-serif;color:black">Speaker: </span></b><b><span style="font-size:13.5pt;line-height:115%;font-family:"Arial",sans-serif">Udunna Anazodo,
PhD</span></b><b><span style="font-size:13.5pt;line-height:115%;font-family:"Times New Roman",serif">
</span></b><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.5pt;font-family:"Arial",sans-serif;color:black;background:white">PET/MRI Physicist and Principal Investigator, Lawson Health Research Institute, London, Ontario</span><o:p></o:p></p>
<p style="text-align:justify;line-height:15.0pt"><strong><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Talk abstract</span></strong><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black"><br>
</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Premature or pathological cognitive aging is a leading cause of disability in older adults, often diagnosed at late and intractable stages of brain disorders (Alzheimer’s disease and other
dementias). It is not clear why some older adults have symptoms suggestive of pathological cognitive aging and others don’t. Decades of research in cognitive aging point to a myriad of factors (biological, environmental -physical, psychosocial, and cultural-
etc.) and precipitating events (injury including ischemic infarcts) that paint a picture of the complex processes and pathways associated with the initiation and development of pathological cognitive aging. Recent evidence suggest that these factors and events
ubiquitously activate a triad of complex biological pathways that act separately or together to exert numerous biological effects that could culminate in accelerated and progressive cognitive decline. Vascular dysfunction - the breakdown in vessel wall structure
and function -, oxidative stress, and inflammation are ubiquitous pathways that are activated systemically in almost all tissues in response to stress, trauma, infection, or injury, and more importantly are independently linked to the pathogenesis of Alzheimer’s
disease and other dementias.</span><o:p></o:p></p>
<p style="text-align:justify;line-height:15.0pt"><span style="font-size:10.0pt;font-family:"Arial",sans-serif">This talk will highlight emerging PET and MRI tools developed by my group to map the sequential and/or synergistic interactions of these key drivers
of pathological cognitive aging in brains of live humans and animal models. And introduce ischemic heart disease post-myocardial infract as a novel disease model for mapping associations of these common drivers of tissue degeneration with known and emerging
risk factors for accelerated cognitive decline – a new approach to understanding the initiation and development of pathological cognitive aging.</span><o:p></o:p></p>
<p style="text-align:justify;line-height:15.0pt"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">To register: <a href="https://www.eventbrite.ca/e/special-seminar-mapping-drivers-of-pathological-cognitive-aging-using-pet-tickets-131912266139" target="_blank" title="https://www.eventbrite.ca/e/killam-seminar-series-programmed-axon-death-and-its-roles-in-human-disease-tickets-124102468825">Eventbrite</a></span></b><o:p></o:p></p>
<p><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Host:
</span></b><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif">Julien Doyon, Director, McConnell Brain Imaging Centre, The Neuro</span></b><o:p></o:p></p>
<p><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Contact :</span></b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black"> </span><span style="font-size:10.0pt">
</span><span style="font-size:10.0pt;font-family:"Arial",sans-serif"><a href="mailto:sasha.kelly@mcgill.ca">Sasha Kelly</a></span><o:p></o:p></p>
<p><span style="font-size:10.0pt;font-family:"Arial",sans-serif"><img border="0" width="960" height="90" style="width:10.0in;height:.9375in" id="Picture_x0020_3" src="cid:image011.png@01D6CE1E.6C4D14E0"></span><o:p></o:p></p>
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<span style="font-size:10.0pt"><img border="0" width="960" height="187" style="width:10.0in;height:1.9479in" id="Picture_x0020_4" src="cid:image012.png@01D6CE1E.6C4D14E0"></span><o:p></o:p></p>
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<p class="MsoNormal"><b><span lang="FR" style="color:#1F497D"> </span></b><span lang="FR" style="color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="FR" style="color:#1F497D"> </span></b><span lang="FR" style="color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="FR" style="color:#1F497D"> </span></b><span lang="FR" style="color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="FR" style="color:#1F497D">Julien Doyon, Ph.D., FRSC, FCAHS <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="FR" style="color:#1F497D">Directeur, Centre d’imagerie cérébrale McConnell<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="FR" style="color:#1F497D">Director, McConnell Brain Imaging Center<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="FR" style="color:#1F497D">Professeur, Département de neurologie et neurochirurgie<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#1F497D">Professor, Department of Neurology and neurosurgery<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#1F497D">McGill University<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="color:#1F497D"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="color:#1F497D">The Neuro</span></b><span style="color:#1F497D"> #OpenScience<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#1F497D">3801 University Street, Montréal, Quebec H3A 2B4<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#1F497D">Bureau/Office: 514-398-5953; Cell.: 514-979-3488<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#1F497D"><a href="mailto:julien.doyon@mcgill.ca">julien.doyon@mcgill.ca</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#1F497D"><a href="http://www.mcgill.ca/neuro/">theneuro.ca</a>;
<a href="https://www.mcgill.ca/bic/">The BIC</a>: <a href="https://www.mcgill.ca/neuro/julien-doyon-phd">
Web Page</a><o:p></o:p></span></p>
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