<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Hi BIC & FYI <br class=""><div><br class=""><blockquote type="cite" class=""><div class="">Begin forwarded message:</div><br class="Apple-interchange-newline"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">From: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">NeuroEvents <<a href="mailto:events.neuro@MCGILL.CA" class="">events.neuro@MCGILL.CA</a>><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Subject: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><b class="">[NEURO] Neuro Event: December 2, 4:00 pm - Feindel Virtual Brain and Mind Seminar: "Focus on the locus: from methods to biomarkers to interventions"</b><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Date: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">November 27, 2020 at 9:45:52 AM EST<br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">To: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><<a href="mailto:NEURO@LISTS.MCGILL.CA" class="">NEURO@LISTS.MCGILL.CA</a>><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Reply-To: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">NeuroEvents <<a href="mailto:events.neuro@MCGILL.CA" class="">events.neuro@MCGILL.CA</a>><br class=""></span></div><br class=""><div class=""><div class="WordSection1" style="page: WordSection1; caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;"><div class=""><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""> <o:p class=""></o:p></div></div><div class=""><div class=""><div align="center" class=""><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="480" style="width: 360pt;"><tbody class=""><tr class=""><td width="100%" style="width: 703.984375px; 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background-repeat: initial initial;" class=""><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="color: white;" class=""><img border="0" id="x_Picture_x0020_15" alt="Events Banner" style="" class="" apple-inline="yes" src="cid:image007.png@01D6C4A1.FBC30890"></span><o:p class=""></o:p></div></td></tr><tr class=""><td style="background-color: white; padding: 0cm; background-position: initial initial; background-repeat: initial initial;" class=""><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="100%" style="width: 723.984375px;"><tbody class=""><tr class=""><td style="padding: 0cm;" class=""><p align="center" style="text-align: center; line-height: 15pt;" class=""><br class=""><o:p class=""></o:p></p><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; line-height: 16.866666793823242px; background-color: white;" class=""><b class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">Wednesday, December</span></b><b class=""><span style="font-family: Arial, sans-serif; color: rgb(32, 31, 30); border: 1pt none windowtext; padding: 0cm;" class=""><span class="Apple-converted-space"> </span>2</span></b><b class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">, 2020 </span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; line-height: 16.866666793823242px; background-color: white;" class=""><b class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">4:00 - 5:00PM EDT</span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; background-color: white;" class=""><b class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">Zoom <span style="background-color: white; background-position: initial initial; background-repeat: initial initial;" class=""><a href="https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-130333419767" target="_blank" title="https://www.eventbrite.ca/e/ipsc-seminar-november-26-tickets-126759871187" style="color: rgb(5, 99, 193); text-decoration: underline;" class="">(registration required)</a></span></span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; background-color: white; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; text-align: start; widows: 2; word-spacing: 0px;" class=""><b class=""><span style="border: 1pt none windowtext; padding: 0cm;" class=""> </span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; background-color: white;" class=""><b class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">Livestreaming via </span></b><span style="font-family: Arial, sans-serif; color: purple; border: 1pt none windowtext; padding: 0cm;" class=""><a href="https://vimeo.com/event/269074" target="_blank" title="https://vimeo.com/475588390" style="color: rgb(5, 99, 193); text-decoration: underline;" class=""><b class="">Vimeo</b></a></span><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; background-color: white; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; widows: 2; word-spacing: 0px;" class=""><b class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class=""> </span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; line-height: 15pt; background-color: white; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; widows: 2; word-spacing: 0px;" class=""><b class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">Speaker:<span class="Apple-converted-space"> </span><a href="http://www.heidijacobs.nl/" style="color: rgb(5, 99, 193); text-decoration: underline;" class="">Dr. Heidi Jacobs</a></span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; line-height: 15pt; background-color: white; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; widows: 2; word-spacing: 0px;" class=""><span style="font-family: Arial, sans-serif;" class="">Assistant Professor of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital / Harvard Medical School, USA</span><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; line-height: 15pt; background-color: white; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; widows: 2; word-spacing: 0px;" class=""><b class=""><span style="border: 1pt none windowtext; padding: 0cm;" class=""> </span></b><o:p class=""></o:p><img apple-inline="yes" id="F594BFB4-0176-469D-8901-2AAC65500052" src="cid:DEE5FBEF-3B65-448D-8733-5302404D89BF" class=""></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; line-height: 15pt; background-color: white;" class=""><b class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">Talk abstract</span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; line-height: 12.7pt; background-color: white; font-variant-ligatures: normal; font-variant-caps: normal; orphans: 2; widows: 2; word-spacing: 0px;" class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm; background-color: white;" class="">Alzheimer’s disease, the most common form of dementia, is characterized by the accumulation of two proteins, beta-amyloid and tau, that contribute to its cognitive and neuropsychiatric symptoms. The deposition of these proteinopathies occurs in a predictable topography, and starts at least two decades before the first clinical symptoms are evident. Given the disappointing results in many clinical trials targeting beta-amyloid, these initial neuropathologic changes can provide new clues to improve the very early detection and provide targets for interventions aimed at delaying cognitive decline. Guided by neuropathology findings, my lab aims to develop methods to identify the earliest Alzheimer’s disease related changes and to examine their biomarker potential. The locus coeruleus – a tiny nucleus in the brainstem – is recognized as one of the first regions to accumulate tau, starting at age 20. The locus coeruleus is a notorious difficult region to image, due to is small size, its location close to the fourth ventricle and the confounding impact of physiological noise. In this talk, I will discuss briefly discuss findings related to three critical areas that my lab tackles: 1) the development of methods to visualize and measure the locus coeruleus in vivo reliably using 3T and 7T magnetic resonance imaging; 2) the application of these methods to relate locus coeruleus properties to initial anatomic patterns of cortical Alzheimer’s disease pathology using positron emission tomography, and their relationship to cognitive dysfunction within the longitudinal Harvard Aging Brain Study; and 3) the opportunity to modulate locus coeruleus functioning and memory performance in healthy older individuals using transcutaneous vagus nerve stimulation.</span><b class=""><span style="border: 1pt none windowtext; padding: 0cm;" class=""> </span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; background-color: white;" class=""><b class=""><span style="border: 1pt none windowtext; padding: 0cm;" class=""> </span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; background-color: white;" class=""><b class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">The Feindel Virtual Brain and Mind (VBM) Seminar Series</span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; background-color: white;" class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">Advancing the vision of Dr. William Feindel (1918–2014), former Director of the Neuro (1972–1984) and Founding Director of the McConnell Brain Imaging Centre (1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.</span><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; background-color: white;" class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class=""> </span><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; background-color: white;" class=""><span style="font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders. If you, or someone you know, would be interested in presenting please contact us to secure a spot on the schedule.</span><o:p class=""></o:p></div><p style="line-height: 15pt;" class=""><span style="font-family: Arial, sans-serif;" class="">Looking forward to reconnecting!</span><o:p class=""></o:p></p><p style="line-height: 15pt; caret-color: rgb(0, 0, 0); font-variant-caps: normal; text-align: start; -webkit-text-stroke-width: 0px; word-spacing: 0px;" class=""><span style="font-family: Arial, sans-serif;" class="">Nathan Spreng<br class="">Boris Bernhardt<br class="">Bratislav Misic</span><o:p class=""></o:p></p><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><strong class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">To register:</span></strong><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""> </span><span style="font-size: 10.5pt; font-family: Arial, sans-serif; color: rgb(149, 79, 114);" class=""><a href="https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-130333419767" target="_blank" title="https://www.eventbrite.ca/e/feindel-virtual-mind-and-brain-seminar-tickets-128284916639" style="color: rgb(5, 99, 193); text-decoration: underline;" class="">Eventbrite</a></span><o:p class=""></o:p></div><p style="line-height: 15pt;" class=""><b class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class="">Contact :</span></b><b class=""><span style="font-size: 10pt; font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class=""><span class="Apple-converted-space"> </span></span></b><span style="font-size: 10pt; font-family: Arial, sans-serif; border: 1pt none windowtext; padding: 0cm;" class=""><a href="mailto:sasha.kelly@mcgill.ca" style="color: rgb(5, 99, 193); text-decoration: underline;" class="">Sasha Kelly</a></span><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""></span><o:p class=""></o:p></p><p align="center" style="text-align: center; line-height: 15pt;" class=""><br class=""><o:p class=""></o:p></p></td></tr></tbody></table></td></tr><tr class=""><td style="background-color: white; padding: 0cm; background-position: initial initial; background-repeat: initial initial;" class=""><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><br class=""><o:p class=""></o:p></div></td></tr><tr style="height: 24pt;" class=""></tr></tbody></table></div></div></div></div></div></blockquote></div><br class=""></div></body></html>