<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Hi BIC & FYI - <br class=""><div><br class=""></div><div><img apple-inline="yes" id="C1CEE214-FA7E-40E6-A964-3282A89CFF2B" src="cid:3D5A2362-4DE1-4CF3-A27C-8596441FE1A4" class=""></div><div><br class=""><blockquote type="cite" class=""><div class="">Begin forwarded message:</div><br class="Apple-interchange-newline"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">From: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">NeuroEvents <<a href="mailto:events.neuro@MCGILL.CA" class="">events.neuro@MCGILL.CA</a>><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Subject: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><b class="">[NEURO] (Reminder) Neuro Event: October 21, 4:00 pm - Feindel Virtual Brain and Mind Seminar at The Neuro: “A novel ex vivo-in situ method for MRI and histological brain assessment”</b><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Date: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">October 21, 2020 at 10:05:37 AM EDT<br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">To: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><<a href="mailto:NEURO@LISTS.MCGILL.CA" class="">NEURO@LISTS.MCGILL.CA</a>><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Reply-To: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">NeuroEvents <<a href="mailto:events.neuro@MCGILL.CA" class="">events.neuro@MCGILL.CA</a>><br class=""></span></div><br class=""><div class=""><div class="WordSection1" style="page: WordSection1; caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;"><div style="margin: 0cm; font-size: 12pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 11pt;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0cm; font-size: 12pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 11pt;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0cm; font-size: 12pt; font-family: Calibri, sans-serif;" class=""><br class=""></div><div align="center" class=""><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="480" style="width: 360pt;"><tbody class=""><tr class=""><td width="100%" style="width: 931.984375px; background-color: white; padding: 7.5pt 7.5pt 0cm; background-position: initial initial; background-repeat: initial initial;" class=""></td></tr><tr class=""><td style="background-color: rgb(71, 10, 105); padding: 0cm; background-position: initial initial; background-repeat: initial initial;" class=""></td></tr><tr class=""><td style="background-color: white; padding: 0cm; background-position: initial initial; background-repeat: initial initial;" class=""><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="100%" style="width: 951.984375px;"><tbody class=""><tr class=""><td style="padding: 0cm;" class=""><h3 style="margin-right: 0cm; margin-left: 0cm; font-size: 13.5pt; font-family: "Times New Roman", serif; font-weight: bold;" class=""><span style="font-family: Arial, sans-serif;" class="">Feindel Virtual Brain and Mind Seminar at The Neuro:<span style="" class=""><br class=""></span>“A novel ex vivo-in situ method for MRI and histological brain assessment”</span><o:p class=""></o:p></h3><h3 style="margin-right: 0cm; margin-left: 0cm; font-size: 13.5pt; font-family: "Times New Roman", serif; font-weight: bold;" class=""><span style="font-family: Arial, sans-serif;" class="">Wednesday<span style="" class="">, October 2</span>1<span style="" class="">, 2020 <br class="">4:00 - 5:00PM EDT<br class="">Zoom </span></span><a href="https://www.mcgill.ca/neuro/channels/event/feindel-virtual-brain-and-mind-seminar-neuro-presents-josefina-maranzano-325328" target="_blank" title="https://www.eventbrite.ca/e/killam-seminar-series-programmed-axon-death-and-its-roles-in-human-disease-tickets-124102468825" style="color: rgb(5, 99, 193); text-decoration: underline;" class=""><span style="font-family: Arial, sans-serif;" class="">(Registration Required)</span></a><o:p class=""></o:p></h3><h3 style="margin-right: 0cm; margin-left: 0cm; font-size: 13.5pt; font-family: "Times New Roman", serif; font-weight: bold; line-height: 15pt;" class=""><span style="font-family: Arial, sans-serif;" class="">Livestreaming via </span><a href="https://vimeo.com/event/269074" target="_blank" title="https://vimeo.com/event/266553" style="color: rgb(5, 99, 193); text-decoration: underline;" class=""><span style="font-family: Arial, sans-serif;" class="">Vimeo</span></a><o:p class=""></o:p></h3><div style="margin: 0cm; font-size: 12pt; font-family: Calibri, sans-serif; line-height: 18.399999618530273px;" class=""><b class=""><span style="font-size: 13.5pt; line-height: 20.700000762939453px; font-family: Arial, sans-serif;" class="">Speaker: </span></b><b class=""><span style="font-size: 13.5pt; line-height: 20.700000762939453px; font-family: Arial, sans-serif;" class="">Dr. Josefina Maranzano</span></b><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 12pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Assistant Professor, Department of Anatomy, Université du Québec à Trois-Rivières</span><o:p class=""></o:p></div><div style="margin: 0cm; font-size: 12pt; font-family: Calibri, sans-serif;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Adjunct Professor, Neurology and Neurosurgery, McGill University</span><o:p class=""></o:p></div><p style="text-align: justify; line-height: 15pt;" class=""><strong class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Talk abstract</span></strong><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""><br class=""></span><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">MRI-histology correlation studies of the ex vivo brain mostly employ fresh, extracted (ex situ) specimens, aldehyde fixed by immersion. This method entails manipulation of the fresh brain during extraction, introducing several disadvantages: deformation of the specimen prior to MRI acquisition; introduction of air bubbles in the sulci, creating artifacts; and uneven or poor fixation of the deeper regions of the brain.</span><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""><o:p class=""></o:p></span></p><p style="text-align: justify; line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">We propose a new paradigm to scan the ex vivo brain, exploiting a technique used by anatomists: fixation by whole body perfusion, which implies fixation of the brain in situ. This allows scanning the brain surrounded by fluids, meninges, and skull, thus preserving the structural relationships of the brain in vivo and avoiding the disadvantages of ex situ scanning. Hence, our study aimed to assess: 1) whether months of in situ fixation results in a loss of fluid around the brain, 2) whether in situ fixation modifies antigenicity for myelin and neuron specific markers, and 3) whether in situ fixation improves the registration of ex vivo brain images to standard neuroanatomical templates in pseudo-Talairach space.<span class="Apple-converted-space"> </span></span><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""><o:p class=""></o:p></span></p><p style="text-align: justify; line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Our initial results show that most specimens retain fluids in the subarachnoid and ventricular spaces; that all T1-weighted images were successfully processed through a validated pipeline used with in vivo MRIs without any modification to run on the ex vivo-in situ scans, successfully registering to a standard brain template, more accurately than an ex vivo-ex situ scan. Further, all specimens exhibited positive antigenicity for myelin and neuron specific antigens. <span class="Apple-converted-space"> </span></span><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""><o:p class=""></o:p></span></p><p style="text-align: justify; line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">We conclude that MRI and histology study of the ex vivo-in situ brain fixed by perfusion is feasible and allows for in situ MRI imaging for at least 10 months post-mortem prior to histology analyses. <span class="Apple-converted-space"> </span></span><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""><o:p class=""></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 7.5pt; font-size: 12pt; font-family: Calibri, sans-serif; text-align: justify; line-height: 15pt;"><b class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">The Feindel Virtual Brain and Mind (VBM) Seminar Series</span></b><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""><br class="">Advancing the vision of Dr. William Feindel (1918–2014), former Director of the Neuro (1972–1984) and Founding Director of the McConnell Brain Imaging Centre (1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.</span><o:p class=""></o:p></p><div style="margin: 0cm; font-size: 12pt; font-family: Calibri, sans-serif; text-align: justify; line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders. If you, or someone you know, would be interested in presenting please contact us to secure a spot on the schedule.</span><o:p class=""></o:p></div><p class="MsoNormal" style="margin: 0cm 0cm 7.5pt; font-size: 12pt; font-family: Calibri, sans-serif; line-height: 15pt;"><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Looking forward to reconnecting!</span><o:p class=""></o:p></p><p class="MsoNormal" style="margin: 0cm 0cm 7.5pt; font-size: 12pt; font-family: Calibri, sans-serif; line-height: 15pt;"><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Nathan Spreng<br class="">Boris Bernhardt<br class="">Bratislav Misic </span><o:p class=""></o:p></p><p style="line-height: 15pt;" class=""><b class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">To register: </span></b><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""><a href="https://www.eventbrite.ca/e/feindel-virtual-brain-and-mind-seminar-with-josefina-maranzano-tickets-125278049017" target="_blank" title="https://www.eventbrite.ca/e/killam-seminar-series-programmed-axon-death-and-its-roles-in-human-disease-tickets-124102468825" style="color: rgb(5, 99, 193); text-decoration: underline;" class=""><b class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Eventbrite</span></b></a></span><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""> </span><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""><o:p class=""></o:p></span></p><div class=""><b class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Contact :</span></b><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""> </span><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""><a href="mailto:sasha.kelly@mcgill.ca" target="_blank" style="color: rgb(5, 99, 193); text-decoration: underline;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class="">Sasha Kelly</span></a><o:p class=""></o:p></span></div><p style="line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""> </span><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""><o:p class=""></o:p></span></p><p style="margin-right: 0cm; margin-bottom: 7.5pt; margin-left: 0cm; line-height: 15pt;" class=""><span style="font-size: 10.5pt; font-family: Arial, sans-serif;" class=""><img border="0" id="Picture_x0020_3" alt="Protect the Neuro" style="" class="" apple-inline="yes" src="cid:image009.png@01D6A791.9CD50130"></span><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""><o:p class=""></o:p></span></p></td></tr><tr class=""><td style="padding: 0cm;" class=""><p align="center" style="text-align: center; line-height: 15pt;" class=""><span style="font-size: 10pt; font-family: "Times New Roman", serif;" class=""> <o:p class=""></o:p></span></p></td></tr></tbody></table></td></tr><tr class=""><td style="background-color: white; padding: 0cm; background-position: initial initial; background-repeat: initial initial;" class=""><div style="margin: 0cm; font-size: 12pt; font-family: Calibri, sans-serif;" class=""><span style="" class=""><img border="0" id="Picture_x0020_2" alt="alt_text" style="" class="" apple-inline="yes" src="cid:image010.png@01D6A791.9CD50130"></span><o:p class=""></o:p></div></td></tr><tr style="height: 24pt;" class=""></tr></tbody></table></div></div></div></blockquote></div><br class=""></body></html>