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<p class="MsoNoSpacing" style="margin-bottom:8.0pt"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black">Quantitative Life Sciences (QLS) and Ludmer Centre</span></b><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:#1F497D">
- </span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black">Joint interdisciplinary Lecture, Tuesday, Jan. 21, 2020</span><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;border:none windowtext 1.0pt;padding:0cm">Topic: </span></b><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:purple;border:none windowtext 1.0pt;padding:0cm">Modelling
and inference methods for brain imaging research</span></b><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;border:none windowtext 1.0pt;padding:0cm">Guest speaker: <u><a href="https://www.bdi.ox.ac.uk/Team/t-e-nichols" target="_blank">Thomas Nichols, PhD</a></u></span></b><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black">Who should attend:</span></b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black"> Faculty and students from McGill University, Concordia University, University
of Montreal and UQAM, and staff from local businesses interested in brain imaging.</span><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black">Location:</span></b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black"> Jeanne Timmins Amphitheatre @ The Neuro, 3801 University St, Montréal, QC, H3A 2B4</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;border:none windowtext 1.0pt;padding:0cm">Registration is <span style="color:red">free</span><span style="color:black"> </span></span></b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black">but
registration is required</span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#1F497D"> -
</span><a href="http://ludmercentre.ca/events">http://ludmercentre.ca/events</a><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;border:none windowtext 1.0pt;padding:0cm">Tuesday, Jan. 21, 2020 </span></b><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:black"><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo3">
<span lang="EN-GB" style="border:none windowtext 1.0pt;padding:0cm">11:30-12:00:
<b>Registration & Coffee</b></span><span style="font-size:7.5pt;font-family:"Verdana",sans-serif"><o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo3">
<span lang="EN-GB" style="border:none windowtext 1.0pt;padding:0cm">12:00-1:00 pm: Lecture, <b>Population Neuroimaging</b>, Thomas Nichols</span><span style="font-size:7.5pt;font-family:"Verdana",sans-serif"><o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo3">
<span lang="EN-GB" style="border:none windowtext 1.0pt;padding:0cm">1:00-1:30 pm: Lunch (free)</span><span style="font-size:7.5pt;font-family:"Verdana",sans-serif"><o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo3">
<span lang="EN-GB" style="border:none windowtext 1.0pt;padding:0cm">1:30-2:30 pm: <b>Tutorial on neuroimaging meta-analysis</b>, Thomas Nichols</span> <span style="font-size:7.5pt;font-family:"Verdana",sans-serif"><o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo3">
<span lang="EN-GB" style="border:none windowtext 1.0pt;padding:0cm">2:30-3:00 pm: Reception & coffee</span> <span style="font-size:7.5pt;font-family:"Verdana",sans-serif"><o:p></o:p></span></li></ul>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;border:none windowtext 1.0pt;padding:0cm">Abstract:</span></b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black;border:none windowtext 1.0pt;padding:0cm"> Brain
imaging studies have traditionally struggled to break into 3-digit sample sizes: e.g., a recent Functional Magnetic Resonance Imaging (fMRI) meta-analysis of emotion found a median sample size of n=13. However, we now have a growing collection studies with
sample sizes with 4-, 5- and even 6-digits. Many of these "population neuroimaging" studies are epidemiological in nature, trying to characterise typical variation in the population to help predict health outcomes across the life span. Dr Nichols will discuss
some of the challenges these studies present, in terms of massive computational burden but also in ways that they expose shortcomings of existing mass univariate techniques. Dr Nichols will also discuss how these datasets present intriguing methodological
problems heretofore absent from neuroimaging statistics. For example, the "null hypothesis fallacy" is how H0 is never strictly true, and yet with 100,000 subjects you'll eventually find some effect even if it is meaningless. This motivates work spatial confidence
sets on meaningful effect sizes (instead of thresholding test statistic images), providing intuitive measures of spatial uncertainty.</span><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black">Bio:</span></b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black"> Dr. Nichols is the Professor of Neuroimaging Statistics and a Wellcome Trust Senior Research
Fellow in Basic Biomedical Science at the Oxford University, Big Data Institute.</span><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black">Dr Nichols is a statistician with a solitary focus on modelling and inference methods for brain imaging research. He has a unique background, with both industrial (Director, Modelling
and Genetics, GlaxoSmithKline) and academic experience, and diverse training including computer science, cognitive neuroscience and statistics.</span><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNoSpacing" style="margin-bottom:8.0pt;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black">The focus of Dr. Nichols work is developing modelling and inference methods for brain image data. He has worked with a variety of types of data, including Positron Emission Tomography
and Magneto- and Electroencephalography, though most of his methods are motivated by Magnetic Resonance Imaging (MRI) and functional MRI (fMRI) in particular. He has extensive experience in modelling large, complex data, particularly known for his contributions
to multiple testing inference for brain imaging. He has developed methods for clinical trials with imaging, as well as methods for integrating genetic and imaging data. His current research involves meta-analysis of neuroimaging studies and informatics tools
to make data-sharing easy and pervasive.</span><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:black"><o:p></o:p></span></p>
<h2 align="center" style="margin-top:0cm;text-align:center;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;box-sizing: border-box;margin:4rem 0px 2rem;outline: 0px;word-break:break-word;word-spacing:0px">
<strong><span style="font-size:12.0pt;font-family:"inherit",serif;color:#333333;border:none windowtext 1.0pt;padding:0cm;font-weight:normal">Joanne Clark, Ludmer Centre </span></strong><strong><span style="font-family:"Calibri Light",sans-serif">Neuroinformatics
& Mental Health | Administrative Director | </span></strong><strong><span style="font-size:12.0pt;font-family:"inherit",serif;color:blue;border:none windowtext 1.0pt;padding:0cm;font-weight:normal"><a href="mailto:joanne.clark@mcgill.ca">joanne.clark@mcgill.ca</a> </span></strong><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#333333"><o:p></o:p></span></h2>
<h2 align="center" style="margin-top:0cm;text-align:center;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-style: initial;text-decoration-color: initial;box-sizing: border-box;margin:4rem 0px 2rem;outline: 0px;word-break:break-word;word-spacing:0px">
<strong><span style="font-size:12.0pt;font-family:"inherit",serif;color:#333333;border:none windowtext 1.0pt;padding:0cm;font-weight:normal">Alex DeGuise, QLS Coordinator | Quantitative Life Sciences | </span></strong><b><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#333333"><a href="mailto:communications.qls@mcgill.ca"><strong><span style="font-family:"inherit",serif;color:blue;border:none windowtext 1.0pt;padding:0cm;font-weight:normal">communications.qls@mcgill.ca</span></strong></a> <o:p></o:p></span></b></h2>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:9.0pt;color:red;mso-fareast-language:EN-CA">Joanne Clark</span></b><span lang="EN-US" style="font-size:9.0pt;color:#5E5E5E;mso-fareast-language:EN-CA"> | Administrative Director/Directrice administratif</span><span lang="EN-US" style="font-size:9.0pt;font-family:"Times New Roman",serif;color:#5E5E5E;mso-fareast-language:EN-CA"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:3.0pt"><span style="font-size:14.0pt;font-family:"Script MT Bold";mso-fareast-language:EN-CA"><img border="0" width="352" height="51" style="width:3.6666in;height:.5312in" id="Picture_x0020_1" src="cid:image001.jpg@01D5CAC7.A78324B0" alt="cid:image001.jpg@01D33208.765A1A60"></span><b><span lang="FR-CA" style="font-size:9.0pt;color:#7030A0;mso-fareast-language:FR-CA"><o:p></o:p></span></b></p>
<p class="MsoNormal"><b><span lang="FR-CA" style="font-size:9.0pt;color:#5E5E5E;mso-fareast-language:FR-CA"><a href="http://ludmercentre.ca/"><span lang="EN-US" style="color:#5E5E5E">Ludmer Centre</span></a></span></b><span lang="EN-US" style="font-size:9.0pt;color:#5E5E5E;mso-fareast-language:FR-CA">
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<p class="MsoNormal" style="text-autospace:none"><span lang="EN-US" style="font-size:9.0pt;color:#5E5E5E;mso-fareast-language:EN-CA"><br>
</span><b><span lang="EN-US" style="font-size:9.0pt;color:#1F4E79;mso-fareast-language:EN-CA">Office: Neuro Development Office, McGill University<o:p></o:p></span></b></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-US" style="font-size:9.0pt;color:red;mso-fareast-language:EN-CA">New office</span><span lang="EN-US" style="font-size:9.0pt;color:#5E5E5E;mso-fareast-language:EN-CA"> 3661 Rue University,
</span><span lang="EN-US" style="font-size:9.0pt;color:red;mso-fareast-language:EN-CA">basement</span><span lang="EN-US" style="font-size:9.0pt;color:#5E5E5E;mso-fareast-language:EN-CA"> | Montréal, Québec | H3A 2B3
<br>
</span><b><span lang="EN-US" style="font-size:9.0pt;color:red;mso-fareast-language:EN-CA">Cell #</span></b><span lang="EN-US" style="font-size:9.0pt;color:red;mso-fareast-language:EN-CA"> +1
<b>514 265 3408</b></span><span lang="EN-US" style="font-size:9.0pt;color:#5E5E5E;mso-fareast-language:EN-CA"> |
<b>E</b> <b><a href="mailto:joanne.clark@mcgill.ca"><span style="color:#5E5E5E">joanne.clark@mcgill.ca</span></a></b>
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<p class="MsoNormal" style="text-autospace:none"><b><span lang="EN-US" style="font-size:9.0pt;color:#1F4E79;mso-fareast-language:EN-CA">Mail : The Montreal Neurological Institute (MNI) & Hospital (the Neuro)</span></b><span lang="EN-US" style="font-size:9.0pt;color:#5E5E5E;mso-fareast-language:EN-CA">
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<p class="MsoNormal" style="text-autospace:none"><span lang="FR-CA" style="font-size:9.0pt;color:#5E5E5E;mso-fareast-language:EN-CA">3801 Rue University | Montréal, Québec | H3A 2B4
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