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<b><i><span style="margin: 0px; font-size: 22pt; font-family: Arial, sans-serif">Neuroimaging of Human Epigenetic Regulation</span></i></b><i></i></p>
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<b><span style="margin: 0px; font-size: 20pt; font-family: Arial, sans-serif">Jacob Hooker, PhD</span></b></p>
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<span style="margin: 0px; font-size: 14pt; line-height: 17.7333px; font-family: Arial, sans-serif">Harvard Medical School</span></p>
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<span style="margin: 0px; font-size: 14pt; line-height: 17.7333px; font-family: Arial, sans-serif">Athinoula A. Martinos Center for Biomedical Imaging<br>
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<b><span lang="fr-CA" style="margin: 0px; font-size: 18pt; font-family: Arial, sans-serif">4 PM TUESDAY, DECEMBER 17, 2019</span></b></p>
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<span lang="fr-CA" style="margin: 0px; font-size: 18pt; font-family: Arial, sans-serif">de Grandpré Communications Centre</span></p>
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<span style="margin: 0px; font-size: 14.67px; font-family: Calibri, sans-serif; background-color: white"><b>Abstract</b>. There are an estimated 5.4 million Americans living with Alzheimer’s disease. Over 4% of all adults have suffered from a serious mental
illness in the past year.</span><span style="margin: 0px; font-size: 14.67px; font-family: Calibri, sans-serif; background-color: white"> <span style="margin: 0px"> </span></span><span style="margin: 0px; font-size: 14.67px; font-family: Calibri, sans-serif; background-color: white">Advances
in the treatment of brain diseases are needed dramatically.</span><span style="margin: 0px; font-size: 14.67px; font-family: Calibri, sans-serif; background-color: white"><span style="margin: 0px"> </span></span><span style="margin: 0px; font-size: 14.67px; font-family: Calibri, sans-serif; background-color: white">The
challenge is daunting given our incredibly limited</span><span style="margin: 0px; font-size: 14.67px; font-family: Calibri, sans-serif; background-color: white"><span style="margin: 0px"> </span>understanding of the dynamic relationship between neurochemicals
in the<span style="margin: 0px"> </span><i>living human brain</i><span style="margin: 0px"> </span>at rest, during stimulation, or through drug manipulation.<span style="margin: 0px"> <span style="margin: 0px"> </span></span>New hybrid, non-invasive imaging
cameras can now provide the first glimpse of both chemical changes in the brain and the functional changes that result.<span style="margin: 0px"> <span style="margin: 0px"> </span></span>What’s more is that these new systems have the potential to allow us
to explore the interplay between two (or more!) neurotransmitter systems and the functional consequence they facilitate in the brain.<span style="margin: 0px"> <span style="margin: 0px"> </span></span>These changes can be resolved into temporal components
and taken together can provide the basis for the first whole-brain neurochemical models.<span style="margin: 0px"> <span style="margin: 0px"> </span></span>My presentation will review human imaging technologies that can be used to understand neurochemistry
and accelerate drug discovery.<span style="margin: 0px"> <span style="margin: 0px"> </span></span>Using examples from my research group, I will explore the signatures of neuroinflammation that exist in neurodegeneration, consider emerging opportunities for
neuroepigenetic imaging, and highlight new technologies that we are developing that are poised to fundamentally change what we can measure in the living human brain.</span><br>
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<div><font size="2">Alexey P. Kostikov, Dr.<br>
Assistant Professor<br>
Department of Neurology & Neurosurgery<br>
McGill University</font><br>
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