<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p
{mso-style-priority:99;
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:12.0pt;
font-family:"Times New Roman",serif;}
p.msonormal0, li.msonormal0, div.msonormal0
{mso-style-name:msonormal;
mso-style-priority:99;
mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:12.0pt;
font-family:"Times New Roman",serif;}
span.EmailStyle19
{mso-style-type:personal;
font-family:"Arial",sans-serif;
color:windowtext;}
span.EmailStyle21
{mso-style-type:personal-reply;
font-family:"Calibri",sans-serif;
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:8.5in 11.0in;
margin:70.85pt 70.85pt 70.85pt 70.85pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-US" link="blue" vlink="purple">
<div class="WordSection1">
<p><strong><u><span lang="FR-CA">LES SÉMINAIRES DE L’UNF</span></u></strong><u><span lang="FR-CA"> /
<strong>SEMINAR UNF</strong> <strong>SERIES</strong></span></u><span lang="FR-CA"><o:p></o:p></span></p>
<table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" style="border-collapse:collapse">
<tbody>
<tr>
<td width="182" valign="top" style="width:136.15pt;padding:0in 5.4pt 0in 5.4pt">
<p class="MsoNormal" style="line-height:115%"><u><span lang="EN-CA" style="color:#222222">Présentateur/ Speaker:</span></u><b><u><span style="font-size:10.0pt;line-height:115%;color:#222222"><o:p></o:p></span></u></b></p>
</td>
<td width="460" valign="top" style="width:344.95pt;padding:0in 5.4pt 0in 5.4pt">
<p class="MsoNormal" style="line-height:115%"><b><span lang="EN-CA" style="color:#222222">Muhammad Saleh, Ph.D.
</span></b><b><span lang="EN-CA" style="font-size:10.0pt;line-height:115%;color:#222222"><o:p></o:p></span></b></p>
</td>
</tr>
<tr>
<td width="182" valign="top" style="width:136.15pt;padding:0in 5.4pt 0in 5.4pt">
<p class="MsoNormal" style="line-height:115%"><u><span lang="EN-CA" style="color:#222222;background:white;mso-highlight:white">Titre/ Title:</span></u><b><u><span lang="EN-CA" style="font-size:10.0pt;line-height:115%;color:#222222"><o:p></o:p></span></u></b></p>
</td>
<td width="460" valign="top" style="width:344.95pt;padding:0in 5.4pt 0in 5.4pt">
<p class="MsoNormal" style="line-height:115%"><b><span lang="EN-CA" style="color:#222222">Universal MRS sequences for single- and multi-metabolite editing<o:p></o:p></span></b></p>
</td>
</tr>
<tr>
<td width="182" valign="top" style="width:136.15pt;padding:0in 5.4pt 0in 5.4pt">
<p class="MsoNormal" style="line-height:115%"><u><span lang="EN-CA" style="color:#222222">Endroit/ Where:</span></u><b><u><span lang="EN-CA" style="font-size:10.0pt;line-height:115%;color:#222222"><o:p></o:p></span></u></b></p>
</td>
<td width="460" valign="top" style="width:344.95pt;padding:0in 5.4pt 0in 5.4pt">
<p class="MsoNormal" style="margin-left:2.5in;text-indent:-2.5in;line-height:115%;background:white">
<b><span lang="EN-CA" style="color:#222222">CRIUGM – Local E1910 </span></b><span lang="EN-CA" style="color:#222222">(</span><a href="http://www.criugm.qc.ca/en/contact.html"><span lang="EN-CA">http://www.criugm.qc.ca/en/contact.html</span></a><span lang="EN-CA" style="color:#222222">)<o:p></o:p></span></p>
</td>
</tr>
<tr>
<td width="182" valign="top" style="width:136.15pt;padding:0in 5.4pt 0in 5.4pt">
<p class="MsoNormal" style="line-height:115%"><u><span lang="EN-CA" style="color:#222222">Date/ When:</span></u><b><u><span style="font-size:10.0pt;line-height:115%;color:#222222"><o:p></o:p></span></u></b></p>
</td>
<td width="460" valign="top" style="width:344.95pt;padding:0in 5.4pt 0in 5.4pt">
<p class="MsoNormal" style="line-height:115%"><b><span lang="EN-CA" style="color:#222222">Vendredi 17 mai, 13h30-14h30/ Friday, May 17<sup>th</sup> 1h30-2h30pm</span></b><b><span lang="EN-CA" style="font-size:10.0pt;line-height:115%;color:#222222"><o:p></o:p></span></b></p>
</td>
</tr>
<tr>
<td width="641" colspan="2" valign="top" style="width:481.1pt;padding:0in 5.4pt 0in 5.4pt">
<p class="MsoNormal" align="center" style="margin-left:.5in;text-align:center;line-height:115%;background:white">
<i><span lang="EN-CA" style="color:#222222"><o:p> </o:p></span></i></p>
<p class="MsoNormal" align="center" style="margin-left:.5in;text-align:center;line-height:115%;background:white">
<i><span lang="EN-CA" style="color:#222222">*La conférence sera présentée en anglais/The seminar will be presented in English*<o:p></o:p></span></i></p>
<p class="MsoNormal" style="margin-left:.5in;line-height:115%;background:white"><i><span lang="EN-CA" style="color:#222222"><o:p> </o:p></span></i></p>
</td>
</tr>
</tbody>
</table>
<p class="MsoNormal"><b><span lang="EN-CA">Muhammad Saleh </span></b><span lang="EN-CA">is a postdoctoral fellow in the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine. Originally from the beautiful
island of Zanzibar, Tanzania. He received his Ph.D. from the University of Cape Town, South Africa, involving prospective motion and magnetic field correction during GABA editing followed by in vivo applications. As a fellow at Hopkins, he develops novel methods
for measuring brain metabolites, including inhibitory neurotransmitter GABA and marker of oxidative stress glutathione (GSH), under the mentorship of Professor Edden. Recently, he standardized these methods across all four major vendors, Philips, Siemens,
GE, and Canon, and disseminated to more than 15 site nationally and internationally to study the pathophysiology of a broad range of neurological diseases. He continues to provide support and collaborates with the researchers from different sites, ranging
from acquisition to post-processing and quantification of data using Gannet analysis package.<b><span style="color:#333333"><o:p></o:p></span></b></span></p>
<p class="MsoNormal"><b><span lang="EN-CA" style="color:#333333"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span lang="EN-CA" style="color:#333333">Abstract:<o:p></o:p></span></b></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span lang="EN-CA">Magnetic Resonance Spectroscopy (MRS) is a non-invasive methodology that allows the quantification of endogenous metabolites in the human body, including the
inhibitory neurotransmitter GABA and redox compound glutathione (GSH) in the brain. However, due to their low concentration, measurement of GABA and GSH using conventional single-voxel MRS is difficult, and at 3T, spectral editing (MEGA-PRESS) is typically
used. In this seminar, he will describe how GABA and GSH can be measured in the brain using spectral editing, including some of the limitations of the methodology. Most previously used edited MRS techniques focus on a single-voxel and are tailored for a specific
metabolite (e.g., GABA, or GSH). He will then introduce a new method developed in our lab, HERMES, which allows multi-metabolite editing in one single MR examination. Finally, he will discuss recent work he has been doing, developing universal sequences across
vendors and present some of new results.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span lang="FR-CA" style="color:#222222">I hope to see you there / En espérant vous voir nombreux.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span lang="FR-CA" style="font-size:9.5pt;color:#222222"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><i><span lang="FR-CA">L'équipe de l'UNF / UNF Team<o:p></o:p></span></i></b></p>
<p class="MsoNormal"><span lang="EN-CA">Site: </span><span lang="FR-CA"><a href="https://unf-montreal.ca/"><span lang="EN-CA">https://unf-montreal.ca</span></a></span><span lang="EN-CA"> <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA">Follow us on twittr at @UNF_montreal </span><span lang="FR-CA"><a href="https://twitter.com/UNF_montreal"><span lang="EN-CA">https://twitter.com/UNF_montreal</span></a></span><span lang="EN-CA"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span lang="EN-CA"><o:p> </o:p></span></p>
</div>
</body>
</html>