[BIC-announce] Abstract and registration for Mark Ha'acke's talk

[Amir Shmuel, Dr.]

Here is the complete abstract of Prof. Ha'acke's talk.

Registration required<https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.eventbrite.ca%2Fe%2Fthe-killam-seminar-series-presents-e-mark-haacke-tickets-493936546507&data=05%7C01%7Camir.shmuel%40mcgill.ca%7C3dc2cc88df5740421e1b08db262a5ded%7Ccd31967152e74a68afa9fcf8f89f09ea%7C0%7C0%7C638145735629135961%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=TPj9GtR6IUbA2luZK9SmxW8RsXywjTf3zZl7n%2Bmu6mk%3D&reserved=0>

Applications of STAGE and MICRO Imaging in Neurodegenerative Disease

E. Mark Haacke<https://can01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fmrc.wayne.edu%2Findex.php%3Fsite%3Dmark&data=05%7C01%7Camir.shmuel%40mcgill.ca%7C3dc2cc88df5740421e1b08db262a5ded%7Ccd31967152e74a68afa9fcf8f89f09ea%7C0%7C0%7C638145735629135961%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=3QBsdCbhUwOgSiJymFFL1Ch2UGVnEJ7rNRxBbgmVEtc%3D&reserved=0>
Professor, Radiology, Wayne State University, USA

Host: Amir Shmuel

Tuesday, March 21, 2023
4 p.m. EDT
De Grandpre Communications Centre, The Neuro, 3801 rue University

Abstract: STAGE is a rapid multi-contrast imaging technique that can provide not only standard T1 and T2 like contrasts but also proton spin density weighted images, T2* weighted images, SWI, R2* maps, QSM maps, water content maps, circle of Willis MRA, auto segmentation of white matter, gray matter and cerebrospinal fluid and simulated fluid-attenuated inversion recovery (FLAIR) in 3 to 6 minutes. Coupled with a new denoising algorithm called CROWN, STAGE can be used to create a new series of homogeneous images that have been corrected for both radiofrequency transmit and receive inhomogeneities.

During the last few years, we have focused on measuring iron content and neuromelanin (NM) in the substantia nigra (SN) for comparing idiopathic Parkinson's disease (PD) with healthy controls and patients with other movement disorders. We have found that the volume of NM, the iron content of the SN, volume of the SN and the N1 sign all together can provide an area under the curve (AUC) of 95% in distinguishing PD from healthy controls. We have developed a template of the midbrain to allow for automatic detection and quantification of these properties. During the process, we used true susceptibility weighted imaging (tSWI) to enhance the N1 sign visibility. Our data has been acquired using STAGE which is a rapid, quantitative, multi-contrast data collection and processing that is vendor agnostic. As such we have created a protocol that can be used for PD studies globally.

We have also developed a new method to image all the vessels in the brain down to 100 microns in size. This method we refer to as microvascular in-vivo contrast revealed origins (MICRO) imaging. It uses an iron based contrast agent Ferumoxytol to instill susceptibility inside all vessels. This then leads to a major signal loss revealing small vessels far better than a conventional T1 reducing contrast agent can. We apply this method to Parkinson's disease and to multiple sclerosis to reveal new vascular findings for both diseases.

The Killam Seminar Series at The Neuro
Supported by the generosity of the Killam Trusts, The Neuro's Killam Seminar series hosts outstanding guest speakers whose research is of interest to our scientific community.

Registration required<https://can01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.eventbrite.ca%2Fe%2Fthe-killam-seminar-series-presents-e-mark-haacke-tickets-493936546507&data=05%7C01%7Camir.shmuel%40mcgill.ca%7C3dc2cc88df5740421e1b08db262a5ded%7Ccd31967152e74a68afa9fcf8f89f09ea%7C0%7C0%7C638145735629135961%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=TPj9GtR6IUbA2luZK9SmxW8RsXywjTf3zZl7n%2Bmu6mk%3D&reserved=0>

Contact: Sasha Kelly<mailto:sasha.kelly at mcgill.ca>, Conference and Events Coordinator, The Neuro

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