From siddiqi at cim.mcgill.ca Wed Jan 9 13:21:23 2013 From: siddiqi at cim.mcgill.ca (Kaleem Siddiqi) Date: Wed, 9 Jan 2013 13:21:23 -0500 Subject: [BIC-announce] Course in Color Vision and Image Processing References: Message-ID: Dear all, Jim Clark is teaching a grad. course in color vision and image processing this term, which may be of interest to some of you. The course outline is below. Best, Kaleem http://www.cim.mcgill.ca/~siddiqi Begin forwarded message: > From: "James J. Clark" > Date: January 9, 2013 10:41:25 AM EST > To: Kaleem Siddiqi > Subject: course syllabus (fwd) > > > Hi Kaleem, here is the syllabus of the grad course I am teaching this term. The time is MW 11:30-1:00 in MDHAR G01. > > Regards, > Jim > -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: ECSE_688_syllabus_v2.pdf Type: application/pdf Size: 11632 bytes Desc: not available URL: -------------- next part -------------- An HTML attachment was scrubbed... URL: From andrea at bic.mni.mcgill.ca Thu Jan 10 11:45:32 2013 From: andrea at bic.mni.mcgill.ca (Andrea Bernasconi) Date: Thu, 10 Jan 2013 11:45:32 -0500 Subject: [BIC-announce] Positions-available-BIC Message-ID: Please see below |Two positions available in the Neuroimaging of Epilepsy Laboratory (NOEL) of the McConnell Brain Imaging Centre (BIC) Neda Ladbon-Bernasconi, MD PhD Andrea Bernasconi, MD NOEL website: http://www.bic.mni.mcgill.ca/~noel/index.html 1) Postdoctoral Fellow We are looking for a Post-doctoral Fellow to join the Neuroimaging of Epilepsy Laboratory (NOEL). NOEL is part of the McConnell Brain Imaging center (BIC) of the Montreal Neurological Institute and Hospital of McGill University (Montreal, Canada). The BIC is an internationally recognized and multidisciplinary centre of excellence in neuroimaging research that is at the hub of a large group of investigators and trainees. We are part of the Epilepsy Group at the Montreal Neurological Hospital, a tertiary center that evaluates approximately 200 patients admitted each year for pre-surgical investigation of drug-resistant seizures. Our lab provides a unique environment fostering links between graduate students and postdoctoral fellows in Neuroscience, Computer Science, Engineering, and Neurology. This multidisciplinary research environment has put NOEL in a unique position to generate a wide range of research perspectives and to develop novel methods of investigation that can directly impact the management and quality of care of patients with epilepsy Our research combines structural and functional MRI with statistical modeling to provide a comprehensive view of the biological basis of epilepsy. Main research topics include automated lesion detection through computational modeling and machine learning, subcortical and cortical brain segmentation, analysis of brain networks based on graphtheoretical methods and independent component analysis, and modeling of disease progression. Starting date: Immediately or upon agreement. Duration: Minimum 2 years Job description: Development and application of new methodological approaches in structural and functional imaging of epilepsy aimed at improving disease understanding and developing image-based biomarkers. Requirements: PhD degree in Biomedical Engineering, Neuroscience or Computer Science, Experience in MRI processing and analysis, Proven programming experience, Strong publication record, Strong communication skills in English (spoken and written), Ability to work in a multidisciplinary team Skills: C/C++, Matlab, MRI processing and analysis (e.g., MINC, FSL, AFNI), computational modeling, software engineering, machine learning, advanced statistics Salary: Competitive, depending on qualifications and experience, Career development, Opportunity to advance to a Research Associate position, depending on performance Required documents: Cover letter, Full CV (including transcripts and publications), Two letters of reference (including one from the PhD Supervisor), Closing date: March 1st, 2013 Send application to: neda.ladbon-bernasconi at mcgill.ca andrea.bernasconi at mcgill.ca ---------------------------------------------------------------------------- ---------------------------------------------------------------------------- ---------------------------------------------------------------- 2) Graduate Student ? PhD level We are looking for a Graduate Student to join the Neuroimaging of Epilepsy Laboratory (NOEL) NOEL is part of the McConnell Brain Imaging center (BIC) of the Montreal Neurological Institute and Hospital of McGill University (Montreal, Canada). The BIC is an internationally recognized and multidisciplinary centre of excellence in neuroimaging research that is at the hub of a large group of investigators and trainees. We are part of the Epilepsy Group at the Montreal Neurological Hospital, a tertiary center that evaluates approximately 200 patients admitted each year for pre-surgical investigation of drug-resistant seizures Our lab provides a unique environment fostering links between graduate students and postdoctoral fellows in Neuroscience, Computer Science, Engineering, and Neurology. This multidisciplinary research environment has put NOEL in a unique position to generate a wide range of research perspectives and to develop novel methods of investigation that can directly impact the management and quality of care of patients with epilepsy. Our research combines structural and functional MRI with statistical modeling to provide a comprehensive view of the biological basis of epilepsy. Main research topics include automated lesion detection through computational modeling and machine learning, subcortical and cortical brain segmentation, analysis of brain networks based on graph-theoretical methods and independent component analysis, and modeling of disease progression. Starting date: According to McGill academic 2013 calendar http://www.mcgill.ca/ipn/ Requirements: Master?s degree in Neuroscience, Computer Science, or Biomedical Engineering, Experience in image processing of the brain is an asset, Good mathematical and statistical background, Strong communication skills in English (spoken and written), Ability to work in a multidisciplinary team Skills: Experience with Unix/Linux operating systems, and scripting languages, C/C++, Matlab, Knowledge in advanced statistics is an asset Required documents: Cover letter, Full CV (including official transcripts and publications), Two letters of reference (including one from the Master?s Supervisor) Send application to: neda.ladbon-bernasconi at mcgill.ca andrea.bernasconi at mcgill.ca (Please do not reply to this e-mail) -------------- next part -------------- An HTML attachment was scrubbed... URL: From jennifer.chew at mcgill.ca Thu Jan 17 10:10:43 2013 From: jennifer.chew at mcgill.ca (Jennifer Chew, Ms.) Date: Thu, 17 Jan 2013 15:10:43 +0000 Subject: [BIC-announce] Advertisement - Two graduate student positions Message-ID: <17E9FB1F37770C46891A5AD521DC19041BB3F85A@EXMBX2010-6.campus.MCGILL.CA> Good morning everyone. Please see attached advert for two graduate student positions. Being sent on behalf of Dr. Natasha Rajah. Jennifer -- Maria Natasha Rajah, Ph.D. Associate Professor, Dept of Psychiatry, McGill University Director, Douglas Brain Imaging Centre, Douglas Institute #2114, CIC Pavilion, Douglas Institute 6875 LaSalle Blvd Verdun, QC, H4H 1R3 PHONE: 514-761-6131 p.2836; FAX: 514-888-4487 http://www.douglas.qc.ca/researcher/maria-natasha-rajah -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: GradStudent_Advert.pdf Type: application/pdf Size: 109686 bytes Desc: GradStudent_Advert.pdf URL: From christophe.grova at mcgill.ca Mon Jan 21 12:18:04 2013 From: christophe.grova at mcgill.ca (Christophe Grova) Date: Mon, 21 Jan 2013 17:18:04 +0000 Subject: [BIC-announce] Seminar in Biomedical Engineering - Wednesday January 23rd - 1 pm - Room 333 - Potential candidate for recruitment in BE/BME dpts In-Reply-To: <9082_1358787801_50FD74D9_9082_45_5_9E1647EDA3EBB44AADA162CEC4C4222E019A7FFE@EXMBX2010-6.campus.MCGILL.CA> References: <9082_1358787801_50FD74D9_9082_45_5_9E1647EDA3EBB44AADA162CEC4C4222E019A7FFE@EXMBX2010-6.campus.MCGILL.CA> Message-ID: <9E1647EDA3EBB44AADA162CEC4C4222E019A804A@EXMBX2010-6.campus.MCGILL.CA> Dear all, Our next Biomedical Engineering Dpt seminar is this coming wednesday Wednesday - January 23rd, at 1 pm Location: Room 333 Lyman Duff Building (Biomedical Engineering Dpt, 3775 University Street). Speaker: Dr George Mitsis PhD, Department of Electrical and Computer Engineering University of Cyprus Dr Mitsis is a potential candidate for joint recruitment in BioEngineering / Biomedical Engineering Dpts, so attendance from our staff members and their students is highly encouraged. Title : Data-driven modeling for dynamic biological / physiological systems Abstract: Data-driven mathematical modeling approaches are well-suited to biological / physiological systems, which are characterized by inherent dynamic nonlinearities, complex, closed-loop configurations that achieve homeostasis and time-varying behavior. Such models may enhance our scientific knowledge regarding the underlying biological mechanisms, lead to the development of sensitive biomarkers and provide the necessary means for model-based therapeutic applications. In order to achieve these objectives, several important modeling choices, such as model class and complexity, should be considered carefully. Here, we discuss efficient computational approaches that may be used to obtain impulse response and/or Volterra models of (possibly time-varying) dynamic systems, which address some of the aforementioned issues. Furthermore, we examine the relation between such data-driven (nonparametric) models to other model classes, i.e. parametric models, in the case of glucose metabolism. We also present the quantitative insights obtained by applying the aforementioned approaches to cerebral hemodynamics and blood flow autoregulation on a systemic and regional level, utilizing transcranial Doppler ultrasound and functional MRI measurements respectively. Finally, we discuss the use of mathematical models in computational oncology and their potential role in designing optimal therapies. A list of upcoming seminars can be found at : http://www.mcgill.ca/bme/news/seminars See you there Christophe Grova *************************** Christophe Grova, PhD Assistant Professor Biomedical Engineering Dpt Neurology and Neurosurgery Dpt Montreal Neurological Institute Centre de Recherches Math?matiques Biomedical Engineering Department - Room 304 McGill University 3775 University Street, Montreal, Quebec, Canada, H3A 2B4 email : christophe.grova at mcgill.ca tel : (514) 398 2516 fax : (514) 398 7461 web: http://www.mni.mcgill.ca/research/gotman/members/christophe.html http://www.bmed.mcgill.ca/ *************************** -------------- next part -------------- An HTML attachment was scrubbed... URL: From jennifer.chew at mcgill.ca Tue Jan 22 10:50:08 2013 From: jennifer.chew at mcgill.ca (Jennifer Chew, Ms.) Date: Tue, 22 Jan 2013 15:50:08 +0000 Subject: [BIC-announce] FW: Scan time available Tuesday 1/22 4-5:30PM In-Reply-To: References: Message-ID: <17E9FB1F37770C46891A5AD521DC19041BB411ED@EXMBX2010-6.campus.MCGILL.CA> PLEASE REPLY TO JONATHAN AT HIS E-MAIL ADDRESS BELOW. Jennifer Hi everyone, Due to a subject cancellation, there is a 1.5 hour slot on the 3T scanner next Tuesday, January 22 from 4-5:30PM. Please email jonathan.berken at mail.mcgill.ca if you are interested in taking the slot! Thanks! -------------- next part -------------- An HTML attachment was scrubbed... URL: From jennifer.chew at mcgill.ca Tue Jan 22 10:57:44 2013 From: jennifer.chew at mcgill.ca (Jennifer Chew, Ms.) Date: Tue, 22 Jan 2013 15:57:44 +0000 Subject: [BIC-announce] =?iso-8859-1?q?FW=3A_PSY6032_-_Prochain_s=E9minair?= =?iso-8859-1?q?e_=2831_janvier_2013=29?= In-Reply-To: <009501cdf81c$8361f460$8a25dd20$@belanger@criugm.qc.ca> References: <009501cdf81c$8361f460$8a25dd20$@belanger@criugm.qc.ca> Message-ID: <17E9FB1F37770C46891A5AD521DC19041BB41238@EXMBX2010-6.campus.MCGILL.CA> For your information. Jennifer From: Francine B?langer [mailto:francine.belanger at criugm.qc.ca] Sent: Monday, January 21, 2013 4:16 PM To: 'Van Der Knaap Maria'; christiane.laurier at umontreal.ca; Jennifer Chew, Ms. Subject: PSY6032 - Prochain s?minaire (31 janvier 2013) Titre : IRM structurelle quantitative des l?sions ?pileptog?nes Conf?rencier : Andrea Bernasconi, MD Associate Professor of Neurology Montreal Neurological Institute and Hospital Date : Jeudi 31 janvier 2013 Heure : 12h00 Lieu : Amphith??tre Le Groupe Maurice 4545, chemin Queen-Mary, Montr?al _______________________________________ Francine B?langer Coordonnatrice administrative UNF / RNQ / RBIQ-QBIN Centre de recherche, Institut universitaire de g?riatrie de Montr?al 4565, chemin Queen-Mary, Montr?al (Qu?bec) H3W 1W5 T?l.: (514) 340-3540 # 4785 T?l?c.: (514) 340-3530 Courriel: francine.belanger at criugm.qc.ca Web UNF: www.unf-montreal.ca Web RBIQ: www.rbiq-qbin.qc.ca -------------- next part -------------- An HTML attachment was scrubbed... URL: From christophe.grova at mcgill.ca Wed Jan 23 07:23:20 2013 From: christophe.grova at mcgill.ca (Christophe Grova) Date: Wed, 23 Jan 2013 12:23:20 +0000 Subject: [BIC-announce] Seminar in Biomedical Engineering - Wednesday January 23rd - 1 pm - Room 333 - Potential candidate for recruitment in BE/BME dpts Message-ID: <9E1647EDA3EBB44AADA162CEC4C4222E019AA956@EXMBX2010-6.campus.MCGILL.CA> Dear all, Our next Biomedical Engineering Dpt seminar is TODAY Wednesday - January 23rd, at 1 pm Location: Room 333 Lyman Duff Building (Biomedical Engineering Dpt, 3775 University Street). Speaker: Dr George Mitsis PhD, Department of Electrical and Computer Engineering University of Cyprus Dr Mitsis is a potential candidate for joint recruitment in BioEngineering / Biomedical Engineering Dpts, so attendance from our staff members and their students is highly encouraged. Title : Data-driven modeling for dynamic biological / physiological systems Abstract: Data-driven mathematical modeling approaches are well-suited to biological / physiological systems, which are characterized by inherent dynamic nonlinearities, complex, closed-loop configurations that achieve homeostasis and time-varying behavior. Such models may enhance our scientific knowledge regarding the underlying biological mechanisms, lead to the development of sensitive biomarkers and provide the necessary means for model-based therapeutic applications. In order to achieve these objectives, several important modeling choices, such as model class and complexity, should be considered carefully. Here, we discuss efficient computational approaches that may be used to obtain impulse response and/or Volterra models of (possibly time-varying) dynamic systems, which address some of the aforementioned issues. Furthermore, we examine the relation between such data-driven (nonparametric) models to other model classes, i.e. parametric models, in the case of glucose metabolism. We also present the quantitative insights obtained by applying the aforementioned approaches to cerebral hemodynamics and blood flow autoregulation on a systemic and regional level, utilizing transcranial Doppler ultrasound and functional MRI measurements respectively. Finally, we discuss the use of mathematical models in computational oncology and their potential role in designing optimal therapies. A list of upcoming seminars can be found at : http://www.mcgill.ca/bme/news/seminars See you there Christophe Grova *************************** Christophe Grova, PhD Assistant Professor Biomedical Engineering Dpt Neurology and Neurosurgery Dpt Montreal Neurological Institute Centre de Recherches Math?matiques Biomedical Engineering Department - Room 304 McGill University 3775 University Street, Montreal, Quebec, Canada, H3A 2B4 email : christophe.grova at mcgill.ca tel : (514) 398 2516 fax : (514) 398 7461 web: http://www.mni.mcgill.ca/research/gotman/members/christophe.html http://www.bmed.mcgill.ca/ *************************** -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- An embedded and charset-unspecified text was scrubbed... Name: ATT00001.txt URL: From jennifer.chew at mcgill.ca Thu Jan 24 10:59:35 2013 From: jennifer.chew at mcgill.ca (Jennifer Chew, Ms.) Date: Thu, 24 Jan 2013 15:59:35 +0000 Subject: [BIC-announce] FW: Rescheduled: Killam Lecture by Geoffrey Hinton, Feb. 22 In-Reply-To: <10626_1358969613_51003B0D_10626_105_1_AF3068FC45A86F4695008A00EE01FECB1BB72706@EXMBX2010-6.campus.MCGILL.CA> References: <10626_1358969613_51003B0D_10626_105_1_AF3068FC45A86F4695008A00EE01FECB1BB72706@EXMBX2010-6.campus.MCGILL.CA> Message-ID: <17E9FB1F37770C46891A5AD521DC19041BB41522@EXMBX2010-6.campus.MCGILL.CA> From: neuro [mailto:NEURO at LISTS.MCGILL.CA] On Behalf Of Enza Ferracane, Ms. Sent: Wednesday, January 23, 2013 2:33 PM To: NEURO at LISTS.MCGILL.CA Subject: [NEURO] Rescheduled: Killam Lecture by Geoffrey Hinton, Feb. 22 Click here to register. "Brains, Sex and Machine Learning" by Prof. Geoffrey Hinton Killam Prize Lecture in Engineering Friday, February 22, 2013 5:30 - 7:30 p.m. Redpath Hall McGill University 3461 rue McTavish (Enter via the McTavish Gates) RSVP: www.mcgill.ca/research/hinton-RSVP -------------- next part -------------- An HTML attachment was scrubbed... URL: From louis.collins at mcgill.ca Fri Jan 25 16:08:41 2013 From: louis.collins at mcgill.ca (D. Louis Collins) Date: Fri, 25 Jan 2013 16:08:41 -0500 Subject: [BIC-announce] Fwd: PET/MR reconstruction - Phd/post-doc position References: <6626F71D1EE57F45BCDBEE7D0A3D207A666F87B3@rghexmbx004> Message-ID: Hi all, Please see the announcement below for a Phd/post-doc positioning Copenhagen. -Louis Begin forwarded message: > From: Flemming Andersen > Subject: PET/MR reconstruction > Date: 25 January, 2013 5:17:53 AM EST > To: "louis.collins at mcgill.ca" > > Hi Louis, > > It has been quite some time since I spend half a year at the MNI together with Anders Rodell during the dreadful ice storm of '98 :) - I am now working at the PET unit in Copenhagen where we recently acquired a PET/MR scanner. We are presently setting up a project in PET reconstruction using MR based priors and are looking for applicable candidates for a Ph.D or post.doc position. > > If you have anybody in mind for such a position, please forward them the attached job offering. > > Best regrads, > Flemming > > Flemming Littrup Andersen, Ph.D > Dataflow and Image Modeling > Rigshospitalet Copenhagen, Dep. PET-3982 > Phone: +45 3545-8143, Mobile: +45 2615-7368 > > > > Denne e-mail indeholder fortrolig information. Hvis du ikke er den rette modtager af denne e-mail eller hvis du modtager den ved en fejltagelse, beder vi dig venligst informere afsender om fejlen ved at bruge svarfunktionen. Samtidig bedes du slette e-mailen med det samme uden at videresende eller kopiere den. -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- A non-text attachment was scrubbed... Name: PETMR_reconstruction_Rigshospitalet_eng.pdf Type: application/pdf Size: 220357 bytes Desc: not available URL: -------------- next part -------------- An HTML attachment was scrubbed... URL: From sylvain at bic.mni.mcgill.ca Sat Jan 26 15:11:11 2013 From: sylvain at bic.mni.mcgill.ca (Sylvain Milot) Date: Sat, 26 Jan 2013 15:11:11 -0500 (EST) Subject: [BIC-announce] Volunteers needed for MNI open house (fwd) Message-ID: ---------- Forwarded message ---------- Date: Sat, 26 Jan 2013 14:24:28 -0500 From: The BAW committee / Le comit? de la Semaine cerveau en t?te To: undisclosed-recipients: ; Subject: Volunteers needed for MNI open house Could you please forward the following email to the students of your department and put us in Cc? thank you for your help Martine volunteer recruitment committee Brain Awareness Montr?al 2013 Find us on Facebook! Twitter ! LinkedIn ! ___________________________________________________________________________________________________________ *Volunteers needed for MNI open house!!* Brain Awareness Montreal is proud to participate again to the Montr?al Neurological Institute open house. With the participation of many volunteers, more than 145 students visit the MNI and participate to interactive workshops about the mysteries of the brain This year again we are looking for volunteers to help us doing tours and demonstrations. If you like working with kids and would like to help, *contact us before March 1st. * bawvolunteers at gmail.com Find us on Facebook! Twitter ! LinkedIn ! *B?n?voles recherch?s pour la journ?e portes ouvertes de INM!!* Cerveau en t?te Montr?al est fier de participer, encore cette ann?e, ? la journ?e portes ouvertes de l?institut neurologique de Montr?al. Avec la participation de b?n?voles, plus de 145 ?l?ves visitent l?INM et participent ? des ateliers sur les myst?res du cerveau. Nous sommes ? la recherche de b?n?voles pour nous aider durant les visit?s guid?es et les ateliers. Si vous aimez travailler avec les enfants et que vous voudriez nous aider, *contactez-nous avant le 1er mars*. bawvolunteers @gmail.com Trouvez nous Facebook! Twitter ! LinkedIn ! From vincent.gracco at mcgill.ca Mon Jan 28 10:15:44 2013 From: vincent.gracco at mcgill.ca (Vincent Gracco, Dr.) Date: Mon, 28 Jan 2013 15:15:44 +0000 Subject: [BIC-announce] CRBLM Seminar on Thursday Message-ID: You are cordially invited to the next CRBLM Seminar: Vous ?tes cordialement invit?s au prochaine conf?rence CRBLM : 01/31/2013 at 3:30pm - Le jeudi 31 janvier 2013, ? 15:30h. Room 101 Rabinovitch House, McGill University 3640 rue de la Montagne, Montreal, QC (enter main door via north-side driveway) Long term dysfunction in mild TBI: the case of concussed athletes Hugo Th??ret, Ph.D. (D?partement de psychologie, Universit? de Montr?al) Abstract: In this talk, Dr. Th??ret will present data showing that sports concussions can lead to long-term impairments in brain plasticity. Neurophysiological, neuroanatomical and neuropsychological data will be presented. Bio: Dr. Th??ret?s research program focuses on motor cortex neurophysiology. He studies the effects of traumatic brain injury on the integrity of inhibitory and excitatory intracortical circuits. He also aims to better understand the motor mechanisms associated with the observation of movements performed by others. The techniques used in his laboratory include transcranial magnetic stimulation, electroencephalography and magnetic resonance imaging. -------------- next part -------------- An HTML attachment was scrubbed... URL: From jennifer.chew at mcgill.ca Wed Jan 30 10:35:26 2013 From: jennifer.chew at mcgill.ca (Jennifer Chew, Ms.) Date: Wed, 30 Jan 2013 15:35:26 +0000 Subject: [BIC-announce] FW: MUHC Grand Rounds Feb. 15: Dr. R. Duman, Yale School of Medicine In-Reply-To: <5111_1359144045_5102E46D_5111_117_2_AF3068FC45A86F4695008A00EE01FECB1BB741FD@EXMBX2010-6.campus.MCGILL.CA> References: <5111_1359144045_5102E46D_5111_117_2_AF3068FC45A86F4695008A00EE01FECB1BB741FD@EXMBX2010-6.campus.MCGILL.CA> Message-ID: <17E9FB1F37770C46891A5AD521DC19041BB43802@EXMBX2010-6.campus.MCGILL.CA> For your information. Jennifer From: neuro [mailto:NEURO at LISTS.MCGILL.CA] On Behalf Of Enza Ferracane, Ms. Sent: Friday, January 25, 2013 3:00 PM To: NEURO at LISTS.MCGILL.CA Subject: [NEURO] MUHC Grand Rounds Feb. 15: Dr. R. Duman, Yale School of Medicine MUHC Psychiatry Grand Rounds RI-MUHC Mental Illness and Addiction Axis Special Guest Speaker Ronald Duman Ph.D. Professor of Psychiatry and Neurobiology, Department of Psychiatry, Yale School of Medicine Neurobiology of Stress, Depression, and Antidepressants: Remodeling Synaptic Connections February 15th, 2013 11:00 ? 12:30 South Seminar Room P1.082 Allan Memorial Institute 1025 Pine Avenue West Neurobiology of stress, depression, and antidepressants: remodeling synaptic connections Molecular and cellular studies have demonstrated opposing actions of stress and antidepressants on the expression of neurotrophic factors that result in structural alterations, including regulation of neurogenesis, dendrite length and spine density in hippocampus and prefrontal cortex (PFC). The deleterious effects of stress could contribute to the reduced volume of these brain regions in depressed patients. Conversely, the actions of antidepressant treatment could be mediated in part by blocking or reversing the atrophy caused by stress and depression. Recent studies have identified a novel, rapid-acting antidepressant, ketamine that addresses the limitations of currently available agents (i.e. delayed onset of action and low response rates). We have found that ketamine, an NMDA receptor antagonist, causes a rapid induction of synaptogenesis and spine formation in the PFC via stimulation of mTOR signaling and increased synthesis of synaptic proteins. These effects of ketamine rapidly reverse the atrophy of PFC neurons caused by chronic stress and correspond to rapid behavioral responses in models of depression. Characterization of a novel signaling pathway also identifies new targets for the development of rapid and efficacious antidepressants without the side effects of ketamine. -------------- next part -------------- An HTML attachment was scrubbed... URL: From vincent.gracco at mcgill.ca Thu Jan 31 10:29:27 2013 From: vincent.gracco at mcgill.ca (Vincent Gracco, Dr.) Date: Thu, 31 Jan 2013 15:29:27 +0000 Subject: [BIC-announce] Reminder--talk today Message-ID: 01/31/2013 at 3:30pm - Le jeudi 31 janvier 2013, ? 15:30h. Room 101 Rabinovitch House, McGill University 3640 rue de la Montagne, Montreal, QC (enter main door via north-side driveway) Long term dysfunction in mild TBI: the case of concussed athletes Hugo Th??ret, Ph.D. (D?partement de psychologie, Universit? de Montr?al) Abstract: In this talk, Dr. Th??ret will present data showing that sports concussions can lead to long-term impairments in brain plasticity. Neurophysiological, neuroanatomical and neuropsychological data will be presented. Bio: Dr. Th??ret?s research program focuses on motor cortex neurophysiology. He studies the effects of traumatic brain injury on the integrity of inhibitory and excitatory intracortical circuits. He also aims to better understand the motor mechanisms associated with the observation of movements performed by others. The techniques used in his laboratory include transcranial magnetic stimulation, electroencephalography and magnetic resonance imaging. -------------- next part -------------- An HTML attachment was scrubbed... URL: -------------- next part -------------- An HTML attachment was scrubbed... URL: